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MOLECULAR TOOL

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  1. Molecular Tool 'HNF6-MO (Imai 2009)' > 
  2. Molecular Tool 'FGF8/17/18>Eph3ΔC (Stolfi 2011)' > 
  3. Molecular Tool 'FGF8/17/18>Pax3/7 (Stolfi 2011)' > 
  4. Region 'REG00000605' > 
  5. Molecular Tool 'GSK126'

Molecular tool card for 'GSK126'

Name

GSK126

Targeted Gene

(EZH1; EZH2; SETD2)

Targeted Gene Group

(EZH1; EZH2; SETD2)

Family

Sequence-based

Type

inhibitor

Supplier

Cayman Chemical

Comment

GSK126 is a selective inhibitor of EZH2 methyltransferase, used to to inhibit H3K27me3.

Regulation

Loss of function

Publication

Zheng et al. (2020). H3K27me3 suppresses sister-lineage somatic gene expression in late embryonic germline cells of the ascidian, Halocynthia roretzi. Dev Biol 460(2):200-214

Sequence

No sequence

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