Name

En>Ngn::WRPW (Stolfi 2011)

Targeted Gene

(NEUROG1; NEUROG2; NEUROG3)

Family

Sequence-based

Type

overexpression_construct

Supplier

Comment

En cis-regulatory sequence drives a dominant negative form of Ngn. Ngn::WRPW was constructed by fusing the bHLH domain (aa 84-173) to a Groucho-recruitment WRPW motif (aa 326-337) from Drosophila Hairy (Wainwright and Ish-Horowicz, 1992).

Regulation

Loss of function

Publication

Stolfi et al. (2011). Neural tube patterning by Ephrin, FGF and Notch signaling relays. Development 138(24):5429-39