Name

FGF8/17/18>CaFGFR (Stolfi 2011)

Targeted Gene

(FGFR1; FGFR2; FGFR3)

Family

Sequence-based

Type

overexpression_construct

Supplier

Comment

FGF8/17/18 cis-regulatory region drives a constitutively active form of FGFR. A constitutively active form of the ciona FGF receptor (Ci-FGFR) was created by fusing the intracellular kinase domain of Ci-FGFR to the first 455 amino acids from the Drosophila torso mutant (Shi and Levine 2008).

Regulation

Gain of function

Publication

Stolfi et al. (2011). Neural tube patterning by Ephrin, FGF and Notch signaling relays. Development 138(24):5429-39