Name

FGF8/17/18>dn-FGFR (Stolfi 2011)

Targeted Gene

(FGFR1; FGFR2; FGFR3)

Family

Sequence-based

Type

overexpression_construct

Supplier

Comment

FGF8/17/18 cis-regulatory sequence drives the dominant-negative form of FGF receptor. The dominant-negative form of Ci-FGFR lacking the intracellular domain was generated using the following primer pair: 5′-aatggcggccgcaATGATACAACTACA AAATACGTTT-3′ and 3′-ggaattcTTAGTTCCCGAACAACA TCACC-5′.

Regulation

Loss of function

Publication

Stolfi et al. (2011). Neuronal subtype specification in the spinal cord of a protovertebrate. Development 138(5):995-1004

Stolfi et al. (2011). Neural tube patterning by Ephrin, FGF and Notch signaling relays. Development 138(24):5429-39