- Molecular Tool 'FGF8/17/18>CaEph3 (Stolfi 2011)'
Molecular tool card for 'FGF8/17/18>CaEph3 (Stolfi 2011)'
Name
FGF8/17/18>CaEph3 (Stolfi 2011)
Targeted Gene
Family
Sequence-based
Type
overexpression_construct
Supplier
Comment
FGF8/17/18 cis-regulatory sequence drives a constitutively active form of Eph3 (KH.C7.568). Constitutively active Eph3 (caEph3) was made by fusing the C-terminal transmembrane and intracellular domains (aa 512-1027) of Eph3 to the self dimerizing N-terminus (aa 1-391) of Drosophila Torso receptor tyrosine kinase (Sprenger and Nusslein-Volhard, 1992).
Regulation
Gain of function