Name

Cytochalasin B

Targeted Gene

(ACTN2; ACTN4)

Targeted Gene Group

(ACTN2; ACTN4)

Family

Sequence-based

Type

inhibitor

Supplier

Millipore Sigma

Comment

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.

Regulation

Loss of function

Publication

Treen et al. (2018). Depletion of Maternal Cyclin B3 Contributes to Zygotic Genome Activation in the Ciona Embryo. Curr. Biol. 28(7):1150-1156.e4

Davidson et al. (2006). FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis. Genes Dev. 20(19):2728-38

Kim et al. (2001). Role of the FGF and MEK signaling pathway in the ascidian embryo. Dev Growth Differ 43(5):521-33

Kumano et al. (2006). Overlapping expression of FoxA and Zic confers responsiveness to FGF signaling to specify notochord in ascidian embryos. Dev Biol 300(2):770-84

Zheng et al. (2020). H3K27me3 suppresses sister-lineage somatic gene expression in late embryonic germline cells of the ascidian, Halocynthia roretzi. Dev Biol 460(2):200-214