Name

U0126

Targeted Gene

(MAP2K1; MAP2K2; MAP2K5)

Targeted Gene Group

(MAP2K1; MAP2K2; MAP2K5)

Family

Sequence-based

Type

inhibitor

Supplier

Calbiochem

Comment

U0126 irreversibly blocks MEK signalling in ascidians (Kim and Nishida, 2001).

Regulation

Loss of function

Publication

Roure et al. (2014). An otx/nodal regulatory signature for posterior neural development in ascidians. PLoS Genet. 10(8):e1004548

Hashimoto et al. (2011). The transcription factor FoxB mediates temporal loss of cellular competence for notochord induction in ascidian embryos. Development 138(12):2591-600

Pasini et al. (2012). Antagonizing retinoic acid and FGF/MAPK pathways control posterior body patterning in the invertebrate chordate Ciona intestinalis. PLoS ONE 7(9):e46193

Tokuoka et al. (2018). Distinct regulation of in two muscle lineages of the ascidian embryo achieves temporal coordination of muscle development. Development 145(11):

Stolfi et al. (2011). Neural tube patterning by Ephrin, FGF and Notch signaling relays. Development 138(24):5429-39

Davidson et al. (2006). FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis. Genes Dev. 20(19):2728-38

Ikeda et al. (2017). Differential temporal control of Foxa.a and Zic-r.b specifies brain versus notochord fate in the ascidian embryo. Development 144(1):38-43

Hudson et al. (2016). Co-expression of Foxa.a, Foxd and Fgf9/16/20 defines a transient mesendoderm regulatory state in ascidian embryos. Elife 5():

Kumano et al. (2006). Overlapping expression of FoxA and Zic confers responsiveness to FGF signaling to specify notochord in ascidian embryos. Dev Biol 300(2):770-84

Kumano et al. (2014). Transcription factor Tbx6 plays a central role in fate determination between mesenchyme and muscle in embryos of the ascidian, Halocynthia roretzi. Dev Growth Differ 56(4):310-22

Fiuza et al. (2020). A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination. Development 147(15):

Sasakura et al. (2012). Retinoic acid-driven Hox1 is required in the epidermis for forming the otic/atrial placodes during ascidian metamorphosis. Development 139(12):2156-60