Name

SB431542

Targeted Gene

(ACVR1B; ACVR1C; TGFBR1)

Targeted Gene Group

(ACVR1B; ACVR1C; TGFBR1)

Family

Sequence-based

Type

inhibitor

Supplier

Tocris

Comment

This inhibitor blocks the TGF beta type I receptors ALK4, ALK5 and ALK7, for Activin and Nodal ligands, without inhibiting other ALK family members that bind to BMP ligands (Inman et al., 2002).

Regulation

Loss of function

Publication

Roure et al. (2014). An otx/nodal regulatory signature for posterior neural development in ascidians. PLoS Genet. 10(8):e1004548

Esposito et al. (2017). Patterning of brain precursors in ascidian embryos. Development 144(2):258-264

Palmquist et al. (2017). Establishment of lateral organ asymmetries in the invertebrate chordate, . Evodevo 8():12

Fiuza et al. (2020). A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination. Development 147(15):