Name

FoxC>DN_FGFR

Targeted Gene

(FGF16; FGF20; FGF9)

Family

Sequence-based

Type

overexpression_construct

Supplier

n/a

Comment

The minimal promoter of FoxC (REG00001205) drives the expression of a dominant negative FGF receptor in the palps lineage. This dominant-negative FGF receptor lacks the intracellular tyrosine kinase domain and its misexpression perturbs FGF-MAPK signaling.

Regulation

Loss of function

Publication

Wagner et al. (2014). Islet is a key determinant of ascidian palp morphogenesis. Development 141(15):3084-92