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MOLECULAR TOOL

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  1. Transcript 'Moocci.CG.ELv1_2.S49...' > 
  2. Transcript 'KH2012:KH.C2.335.v1....' > 
  3. Transcript 'Boleac.CG.SB_v3.S4.g...' > 
  4. Transcript 'Moocci.CG.ELv1_2.S49...' > 
  5. Molecular Tool 'Dmrt>BMPR1(CA)'

Molecular tool card for 'Dmrt>BMPR1(CA)'

Name

Dmrt>BMPR1(CA)

Targeted Gene

(ACVRL1; BMPR1A; BMPR1B)

Family

Sequence-based

Type

overexpression_construct

Supplier

n/a

Comment

Dmrt regulatory region (sequence below) drives a constitutively active form of the BMP receptor (BMPR1CA) for cell-autonomous activation of BMP signalling. In these experiments, activation is restricted to Dmrt+ cells, which form the anterior neural plate and adjacent anterior ectoderm.

Regulation

Gain of function

Publication

Abitua et al. (2015). The pre-vertebrate origins of neurogenic placodes. Nature 524(7566):462-5

Sequence

>KhS544:4240-5239_Dmrttagtagggtggaggaagatgggacacctttggcacata
atatccaaatatccttaccccgttttacacaattaacagcggtatatgggagtcgtaaga
attccgttttataattatttgcatgttctttgtttgctactaaattggacgacaaaatgt
agtcaaaaggtgtctaatcttcccctaccctactatacgacttggggcatagttataaag
ttattccgtttcatttcttggcgttaacccgacgatcagtaattaacgatattcttcata
aataaataatgcgagaactgcaacaggactagggaagttacttaagcgagcatgtgatta
gaaattgccactgaagcactttaaaatgccgccaaaacacatacaccttcatgacacatt
gttttacagaatctcaatttaaaacccgtcgacaattatcggatttccgccgcagagtca
caggaagttgttttgcttaataatacttgttttagataagctgttatgttgctcaatgaa
taacaataatgtttacgttggttgttgtggcaatgtacattgtaacttccacaaacctct
cagagggcaaacacattaagcaaactgaatttgccaagtacttcgggaagtcactgataa
gcggacaatacgaagcgatcacagggaattgtcgcacgccagaatgtaaacaaaaacatc
gcctgtgcaccgcgcgatcgaagacacacagcgctgactaattgaccaacacaaaagcga
ggaaagaaaaaaaagcgaaaacgagaacgggatattaattgtacacgattgtgacgtaaa
ttcgaggcattttttcttccgaaatcgagcggtttaaatacctcgcgtctttattaggta
caatcatattgccttgataccttgcttagaacagtgaatacatataaatcgtattaaaag
ctttagagtgttaaaccaaagagttacagaaattatagcaaacagttcgtttaactggca
tg

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