Name

DAPT

Targeted Gene

(HM13; SPPL2B; SPPL3)

Targeted Gene Group

(HM13; SPPL2B; SPPL3)

Family

Sequence-based

Type

inhibitor

Supplier

Calbiochem

Comment

DAPT inhibits gamma-secretase. Application of DAPT has previously been shown to inhibit Notch-Delta signalling in zebrafish embryos (Geling et al., 2002).

Regulation

Loss of function

Publication

Hamada et al. (2015). Evolution of the chordate regeneration blastema: Differential gene expression and conserved role of notch signaling during siphon regeneration in the ascidian Ciona. Dev. Biol. 405(2):304-15

Stolfi et al. (2011). Neural tube patterning by Ephrin, FGF and Notch signaling relays. Development 138(24):5429-39

Esposito et al. (2017). Patterning of brain precursors in ascidian embryos. Development 144(2):258-264