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MOLECULAR TOOL

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  1. Transcript 'KH2012:KH.C5.109.v5....' > 
  2. Transcript 'KH2012:KH.L4.23.v1.R...' > 
  3. Molecular Tool 'Brachyury>Twist' > 
  4. Transcript 'KH2012:KH.C5.109.v2....' > 
  5. Molecular Tool 'Compound E (ab142164)'

Molecular tool card for 'Compound E (ab142164)'

Name

Compound E (ab142164)

Targeted Gene

(NOTCH1; NOTCH2; NOTCH3)

Targeted Gene Group

(NOTCH1; NOTCH2; NOTCH3)

Family

Sequence-based

Type

inhibitor

Supplier

Abcam

Comment

Cell-permeable, selective, non-competitive, potent γ-secretase inhibitor (IC50 = 0.3 nM). Active in vitro and in vivo.

Regulation

Loss of function

Publication

Hamada et al. (2015). Evolution of the chordate regeneration blastema: Differential gene expression and conserved role of notch signaling during siphon regeneration in the ascidian Ciona. Dev. Biol. 405(2):304-15

Sequence

No sequence

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