- Molecular Tool 'Ci-Bra -3.5Kb/Ci-Su(H)DBD-WRPW'
Molecular tool card for 'Ci-Bra -3.5Kb/Ci-Su(H)DBD-WRPW'
Name
Ci-Bra -3.5Kb/Ci-Su(H)DBD-WRPW
Targeted Gene
Family
Sequence-based
Type
null
Supplier
n/a
Comment
Putative dominant negative form of Su(H) protein placed under the control of the Brachyury cis-regulatory region (-3.5Kb to 17 first codons). The truncated form of Su(H) contains only the DNA binding region attached to the repression domain of Ci-Snail and the drosophila Hairy repressor, the latter protein contains the C-terminal sequence motif WRPW which interacts with the evolutionarily conserved co-repressor Groucho.
Regulation
Loss of function
No sequence