Name

Aphidicolin

Targeted Gene

(NDUFB3)

Targeted Gene Group

(NDUFB3)

Family

Sequence-based

Type

inhibitor

Supplier

Sigma-Aldrich

Comment

Aphidicolin blocks DNA synthesis in sea urchin embryos by interfering with the activity of DNA polymerase-alpha. This tool is associated to a DNA polymerase alpha in ANISEED (gene with the best annotation).

Regulation

Loss of function

Publication

Treen et al. (2018). Depletion of Maternal Cyclin B3 Contributes to Zygotic Genome Activation in the Ciona Embryo. Curr. Biol. 28(7):1150-1156.e4

Kataoka et al. (2009). Mechanism of DNA replication-dependent transcriptional activation of the acetylcholinesterase gene in the Ciona intestinalis embryo. Dev. Growth Differ. 51(9):841-50