IPR Term	Analysis	Definition
EGF-like_dom	ProSiteProfiles	EGF-like domain
EGF-like_CS	Pfam	EGF-like, conserved site
Notch_dom	PRINTS	Notch domain
EGF-like_CS	ProSitePatterns	EGF-like, conserved site
Ankyrin_rpt-contain_dom	ProSiteProfiles	Ankyrin repeat-containing domain
Notch_NOD_dom	SMART	Notch, NOD domain
Notch_dom	SMART	Notch domain
EGF-type_Asp/Asn_hydroxyl_site	ProSitePatterns	EGF-type aspartate/asparagine hydroxylation site
Ankyrin_rpt	ProSiteProfiles	Ankyrin repeat
Growth_fac_rcpt_cys_sf	SUPERFAMILY	Growth factor receptor cysteine-rich domain superfamily
Notch-like_dom_sf	SUPERFAMILY	Notch-like domain superfamily
Notch_dom	ProSiteProfiles	Notch domain
DUF3454_notch	Pfam	Domain of unknown function DUF3454, notch
Ankyrin_rpt-contain_sf	Gene3D	Ankyrin repeat-containing domain superfamily
EGF-like_dom	Pfam	EGF-like domain
EGF-like_dom	SMART	EGF-like domain
Notch_dom	Pfam	Notch domain
Notch_NODP_dom	SMART	Notch, NODP domain
EGF_Ca-bd_CS	ProSitePatterns	EGF-like calcium-binding, conserved site
Notch	PIRSF	Notch
EGF-like_Ca-bd_dom	SMART	EGF-like calcium-binding domain
Ankyrin_rpt-contain_dom	CDD	Ankyrin repeat-containing domain
Ankyrin_rpt-contain_sf	SUPERFAMILY	Ankyrin repeat-containing domain superfamily
Notch_NOD_dom	Pfam	Notch, NOD domain
Ankyrin_rpt	SMART	Ankyrin repeat
Ankyrin_rpt-contain_dom	Pfam	Ankyrin repeat-containing domain
EGF-like_Ca-bd_dom	Pfam	EGF-like calcium-binding domain
DUF3454_notch	SMART	Domain of unknown function DUF3454, notch
Notch_NODP_dom	Pfam	Notch, NODP domain

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
Golgi membrane	Orthology	cellular component
angiogenesis	Orthology	biological process
chromatin binding	Orthology	molecular function
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
transmembrane signaling receptor activity	Orthology	molecular function
calcium ion binding	Orthology	molecular function
protein binding	Orthology	molecular function
extracellular region	Orthology	cellular component
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
endoplasmic reticulum	Orthology	cellular component
endoplasmic reticulum membrane	Orthology	cellular component
Golgi apparatus	Orthology	cellular component
cytosol	Orthology	cellular component
plasma membrane	Orthology	cellular component
integral component of plasma membrane	Orthology	cellular component
adherens junction	Orthology	cellular component
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
regulation of transcription from RNA polymerase II promoter	Orthology	biological process
transcription initiation from RNA polymerase II promoter	Orthology	biological process
apoptotic process	Orthology	biological process
immune response	Orthology	biological process
Notch signaling pathway	Orthology	biological process
multicellular organism development	Orthology	biological process
spermatogenesis	Orthology	biological process
nervous system development	Orthology	biological process
axonogenesis	Orthology	biological process
brain development	Orthology	biological process
heart development	Orthology	biological process
positive regulation of cell proliferation	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process
cell surface	Orthology	cellular component
regulation of gene expression	Orthology	biological process
negative regulation of gene expression	Orthology	biological process
membrane	Orthology	cellular component
integral component of membrane	Orthology	cellular component
apical plasma membrane	Orthology	cellular component
enzyme binding	Orthology	molecular function
cell differentiation	Orthology	biological process
neuron differentiation	Orthology	biological process
cytoplasmic vesicle	Orthology	cellular component
response to lipopolysaccharide	Orthology	biological process
regulation of cell proliferation	Orthology	biological process
identical protein binding	Orthology	molecular function
positive regulation of apoptotic process	Orthology	biological process
negative regulation of apoptotic process	Orthology	biological process
sequence-specific DNA binding	Orthology	molecular function
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
metal ion binding	Orthology	molecular function
protein heterodimerization activity	Orthology	molecular function
negative regulation of cell death	Orthology	biological process
cell periphery	Orthology	cellular component
negative regulation of canonical Wnt signaling pathway	Orthology	biological process
transcription regulatory region DNA binding	Orthology	molecular function
endomembrane system	Orthology	cellular component
animal organ development	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
cell development	Orthology	biological process
generation of neurons	Orthology	biological process
cell division	Orthology	biological process
macromolecular complex	Orthology	cellular component
enzyme regulator activity	Orthology	molecular function
receptor binding	Orthology	molecular function
system development	Orthology	biological process
anatomical structure development	Orthology	biological process
regulation of signal transduction	Orthology	biological process
neurogenesis	Orthology	biological process
anatomical structure formation involved in morphogenesis	Orthology	biological process
cytoskeleton	Orthology	cellular component
developmental process	Orthology	biological process
immune system process	Orthology	biological process
cell migration	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
cellular response to organic substance	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
signal transduction	Orthology	biological process
DNA binding	Orthology	molecular function
wound healing	Orthology	biological process
regulation of catalytic activity	Orthology	biological process
cell adhesion molecule binding	Orthology	molecular function
small GTPase mediated signal transduction	Orthology	biological process
central nervous system development	Orthology	biological process
blood vessel morphogenesis	Orthology	biological process
cell proliferation	Orthology	biological process
blood vessel development	Orthology	biological process
intracellular signal transduction	Orthology	biological process
protein phosphorylation	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
Golgi membrane	Hs	cellular component
core promoter binding	Hs	molecular function
transcriptional activator activity, RNA polymerase II transcription factor binding	Hs	molecular function
angiogenesis	Hs	biological process
acrosomal vesicle	Hs	cellular component
cell fate specification	Hs	biological process
cell fate determination	Hs	biological process
epithelial to mesenchymal transition	Hs	biological process
liver development	Hs	biological process
heart looping	Hs	biological process
sprouting angiogenesis	Hs	biological process
positive regulation of neuroblast proliferation	Hs	biological process
MAML1-RBP-Jkappa- ICN1 complex	Hs	cellular component
endocardium development	Hs	biological process
endocardium morphogenesis	Hs	biological process
atrioventricular valve morphogenesis	Hs	biological process
endocardial cushion development	Hs	biological process
endocardial cushion morphogenesis	Hs	biological process
cardiac ventricle morphogenesis	Hs	biological process
cardiac atrium morphogenesis	Hs	biological process
ventricular trabecula myocardium morphogenesis	Hs	biological process
pericardium morphogenesis	Hs	biological process
chromatin binding	Hs	molecular function
transcription factor activity, sequence-specific DNA binding	Hs	molecular function
enzyme inhibitor activity	Hs	molecular function
receptor activity	Hs	molecular function
transmembrane signaling receptor activity	Hs	molecular function
Notch binding	Hs	molecular function
calcium ion binding	Hs	molecular function
protein binding	Hs	molecular function
extracellular region	Hs	cellular component
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
endoplasmic reticulum	Hs	cellular component
endoplasmic reticulum membrane	Hs	cellular component
Golgi apparatus	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
integral component of plasma membrane	Hs	cellular component
adherens junction	Hs	cellular component
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
regulation of transcription from RNA polymerase II promoter	Hs	biological process
transcription initiation from RNA polymerase II promoter	Hs	biological process
apoptotic process	Hs	biological process
immune response	Hs	biological process
humoral immune response	Hs	biological process
cell cycle arrest	Hs	biological process
Notch signaling pathway	Hs	biological process
positive regulation of transcription of Notch receptor target	Hs	biological process
multicellular organism development	Hs	biological process
spermatogenesis	Hs	biological process
determination of left/right symmetry	Hs	biological process
compartment pattern specification	Hs	biological process
nervous system development	Hs	biological process
axonogenesis	Hs	biological process
brain development	Hs	biological process
foregut morphogenesis	Hs	biological process
endoderm development	Hs	biological process
heart development	Hs	biological process
positive regulation of cell proliferation	Hs	biological process
negative regulation of cell proliferation	Hs	biological process
epidermis development	Hs	biological process
regulation of Notch signaling pathway	Hs	biological process
animal organ morphogenesis	Hs	biological process
cell surface	Hs	cellular component
glial cell differentiation	Hs	biological process
regulation of gene expression	Hs	biological process
negative regulation of gene expression	Hs	biological process
positive regulation of epithelial to mesenchymal transition	Hs	biological process
regulation of somitogenesis	Hs	biological process
actin cytoskeleton	Hs	cellular component
membrane	Hs	cellular component
integral component of membrane	Hs	cellular component
apical plasma membrane	Hs	cellular component
stem cell population maintenance	Hs	biological process
enzyme binding	Hs	molecular function
neural tube development	Hs	biological process
hemopoiesis	Hs	biological process
cell differentiation	Hs	biological process
neuron differentiation	Hs	biological process
keratinocyte differentiation	Hs	biological process
negative regulation of ossification	Hs	biological process
lung development	Hs	biological process
embryonic limb morphogenesis	Hs	biological process
regulation of cell migration	Hs	biological process
positive regulation of cell migration	Hs	biological process
positive regulation of BMP signaling pathway	Hs	biological process
negative regulation of BMP signaling pathway	Hs	biological process
intracellular receptor signaling pathway	Hs	biological process
forebrain development	Hs	biological process
animal organ regeneration	Hs	biological process
cytoplasmic vesicle	Hs	cellular component
chromatin DNA binding	Hs	molecular function
response to lipopolysaccharide	Hs	biological process
embryonic hindlimb morphogenesis	Hs	biological process
tube formation	Hs	biological process
skeletal muscle cell differentiation	Hs	biological process
cellular response to vascular endothelial growth factor stimulus	Hs	biological process
transcription factor activity, ligand-activated RNA polymerase II transcription factor binding	Hs	molecular function
regulation of cell proliferation	Hs	biological process
tissue regeneration	Hs	biological process
identical protein binding	Hs	molecular function
positive regulation of apoptotic process	Hs	biological process
negative regulation of apoptotic process	Hs	biological process
negative regulation of catalytic activity	Hs	biological process
receptor complex	Hs	cellular component
sequence-specific DNA binding	Hs	molecular function
cell fate commitment	Hs	biological process
cadherin binding	Hs	molecular function
negative regulation of cell differentiation	Hs	biological process
positive regulation of endothelial cell differentiation	Hs	biological process
negative regulation of neuron differentiation	Hs	biological process
negative regulation of osteoblast differentiation	Hs	biological process
negative regulation of Notch signaling pathway	Hs	biological process
positive regulation of Notch signaling pathway	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
negative regulation of growth rate	Hs	biological process
positive regulation of JAK-STAT cascade	Hs	biological process
negative regulation of photoreceptor cell differentiation	Hs	biological process
positive regulation of Ras protein signal transduction	Hs	biological process
bone remodeling	Hs	biological process
metal ion binding	Hs	molecular function
protein heterodimerization activity	Hs	molecular function
somatic stem cell division	Hs	biological process
neuron fate commitment	Hs	biological process
astrocyte differentiation	Hs	biological process
oligodendrocyte differentiation	Hs	biological process
branching morphogenesis of an epithelial tube	Hs	biological process
artery morphogenesis	Hs	biological process
venous blood vessel morphogenesis	Hs	biological process
regulation of epithelial cell proliferation	Hs	biological process
positive regulation of epithelial cell proliferation	Hs	biological process
regulation of neurogenesis	Hs	biological process
negative regulation of neurogenesis	Hs	biological process
regulation of developmental process	Hs	biological process
cardiac muscle tissue morphogenesis	Hs	biological process
cardiac muscle cell proliferation	Hs	biological process
negative regulation of glial cell proliferation	Hs	biological process
cilium assembly	Hs	biological process
negative regulation of cell death	Hs	biological process
arterial endothelial cell differentiation	Hs	biological process
endocardial cell differentiation	Hs	biological process
positive regulation of ERK1 and ERK2 cascade	Hs	biological process
left/right axis specification	Hs	biological process
cell periphery	Hs	cellular component
glomerular capillary formation	Hs	biological process
negative regulation of canonical Wnt signaling pathway	Hs	biological process
neuronal stem cell population maintenance	Hs	biological process
negative regulation of stem cell differentiation	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
Golgi membrane	Hs	cellular component	1838	0.0
core promoter binding	Hs	molecular function	1838	0.0
transcriptional activator activity, RNA polymerase II transcription factor binding	Hs	molecular function	1838	0.0
acrosomal vesicle	Hs	cellular component	1838	0.0
MAML1-RBP-Jkappa- ICN1 complex	Hs	cellular component	1838	0.0
chromatin binding	Hs	molecular function	1838	0.0
transcription factor activity, sequence-specific DNA binding	Hs	molecular function	1838	0.0
enzyme inhibitor activity	Hs	molecular function	1838	0.0
receptor activity	Hs	molecular function	1838	0.0
transmembrane signaling receptor activity	Hs	molecular function	1838	0.0
Notch binding	Hs	molecular function	1838	0.0
calcium ion binding	Hs	molecular function	1838	0.0
protein binding	Hs	molecular function	1838	0.0
extracellular region	Hs	cellular component	1838	0.0
nucleus	Hs	cellular component	1838	0.0
nucleoplasm	Hs	cellular component	1838	0.0
cytoplasm	Hs	cellular component	1838	0.0
endoplasmic reticulum	Hs	cellular component	1838	0.0
endoplasmic reticulum membrane	Hs	cellular component	1838	0.0
Golgi apparatus	Hs	cellular component	1838	0.0
cytosol	Hs	cellular component	1838	0.0
plasma membrane	Hs	cellular component	1838	0.0
integral component of plasma membrane	Hs	cellular component	1823	0.0
adherens junction	Hs	cellular component	1838	0.0
cell surface	Hs	cellular component	1838	0.0
actin cytoskeleton	Hs	cellular component	1574	0.0
membrane	Hs	cellular component	1838	0.0
integral component of membrane	Hs	cellular component	1838	0.0
apical plasma membrane	Hs	cellular component	1838	0.0
enzyme binding	Hs	molecular function	1838	0.0
cytoplasmic vesicle	Hs	cellular component	1838	0.0
chromatin DNA binding	Hs	molecular function	1838	0.0
transcription factor activity, ligand-activated RNA polymerase II transcription factor binding	Hs	molecular function	1823	0.0
identical protein binding	Hs	molecular function	1574	0.0
receptor complex	Hs	cellular component	1838	0.0
sequence-specific DNA binding	Hs	molecular function	1838	0.0
cadherin binding	Hs	molecular function	1574	0.0
metal ion binding	Hs	molecular function	1838	0.0
protein heterodimerization activity	Hs	molecular function	1838	0.0
cell periphery	Hs	cellular component	1838	0.0

GO Term	Analysis	Type	e-value
calcium ion binding	SMART	molecular function	1.1E-12
protein binding	SMART	molecular function	4.4E-4
Notch signaling pathway	PIRSF	biological process	2.6E-291
multicellular organism development	SMART	biological process	7.5E-18
integral component of membrane	PIRSF	cellular component	2.6E-291
cell differentiation	PIRSF	biological process	2.6E-291
regulation of developmental process	PIRSF	biological process	2.6E-291