IPR Term	Analysis	Definition
TIR_dom	ProSiteProfiles	Toll/interleukin-1 receptor homology (TIR) domain
TIR_dom	SMART	Toll/interleukin-1 receptor homology (TIR) domain
Death_domain	ProSiteProfiles	Death domain
Toll_tir_struct_dom_sf	SUPERFAMILY	Toll/interleukin-1 receptor homology (TIR) domain superfamily
Death_domain	Pfam	Death domain
MyD88_Death	CDD	MyD88, death domain
TIR_dom	Pfam	Toll/interleukin-1 receptor homology (TIR) domain
Toll_tir_struct_dom_sf	Gene3D	Toll/interleukin-1 receptor homology (TIR) domain superfamily
Myelin_different_resp_MyD88	PANTHER	Myeloid differentiation primary response protein MyD88
Death_domain	SMART	Death domain
DEATH-like_dom_sf	SUPERFAMILY	Death-like domain superfamily

GO Term	Annotation Origin	Type
Golgi membrane	Blast	cellular component
immune system process	Orthology	biological process
RNA binding	Blast	molecular function
transmembrane signaling receptor activity	Blast	molecular function
receptor binding	Orthology	molecular function
protein binding	Orthology	molecular function
intracellular	Blast	cellular component
nucleus	Orthology	cellular component
cytoplasm	Orthology	cellular component
lysosomal membrane	Blast	cellular component
endosome	Orthology	cellular component
early endosome	Blast	cellular component
endoplasmic reticulum	Blast	cellular component
endoplasmic reticulum membrane	Blast	cellular component
cytosol	Orthology	cellular component
plasma membrane	Orthology	cellular component
integral component of plasma membrane	Blast	cellular component
apoptotic process	Orthology	biological process
defense response	Orthology	biological process
signal transduction	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
regulation of gene expression	Orthology	biological process
positive regulation of gene expression	Orthology	biological process
membrane	Blast	cellular component
integral component of membrane	Blast	cellular component
cytokine-mediated signaling pathway	Orthology	biological process
response to lipopolysaccharide	Orthology	biological process
regulation of cell proliferation	Orthology	biological process
identical protein binding	Orthology	molecular function
negative regulation of apoptotic process	Orthology	biological process
innate immune response	Orthology	biological process
cellular response to stress	Orthology	biological process
intracellular signal transduction	Orthology	biological process
protein phosphorylation	Orthology	biological process
intracellular organelle part	Orthology	cellular component
whole membrane	Orthology	cellular component
bounding membrane of organelle	Orthology	cellular component
organelle	Orthology	cellular component
postsynapse	Orthology	cellular component
neuron part	Orthology	cellular component
immune response	Orthology	biological process
cellular response to organic substance	Orthology	biological process
response to molecule of bacterial origin	Orthology	biological process
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
positive regulation of signal transduction	Orthology	biological process
response to bacterium	Orthology	biological process
mRNA catabolic process	Orthology	biological process
cell development	Orthology	biological process
cell migration	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
toll-like receptor signaling pathway	Hs	biological process
immune system process	Hs	biological process
MyD88-dependent toll-like receptor signaling pathway	Hs	biological process
receptor binding	Hs	molecular function
Toll binding	Hs	molecular function
death receptor binding	Hs	molecular function
interleukin-1 receptor binding	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
cytoplasm	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
apoptotic process	Hs	biological process
inflammatory response	Hs	biological process
signal transduction	Hs	biological process
cell surface receptor signaling pathway	Hs	biological process
JNK cascade	Hs	biological process
Toll signaling pathway	Hs	biological process
response to virus	Hs	biological process
endosome membrane	Hs	cellular component
regulation of gene expression	Hs	biological process
positive regulation of gene expression	Hs	biological process
postsynaptic density	Hs	cellular component
immunoglobulin mediated immune response	Hs	biological process
cytokine-mediated signaling pathway	Hs	biological process
lipopolysaccharide-mediated signaling pathway	Hs	biological process
positive regulation of type I interferon production	Hs	biological process
response to peptidoglycan	Hs	biological process
response to lipopolysaccharide	Hs	biological process
toll-like receptor 9 signaling pathway	Hs	biological process
Toll-like receptor binding	Hs	molecular function
regulation of cell proliferation	Hs	biological process
identical protein binding	Hs	molecular function
negative regulation of apoptotic process	Hs	biological process
positive regulation of I-kappaB kinase/NF-kappaB signaling	Hs	biological process
protein self-association	Hs	molecular function
negative regulation of growth of symbiont in host	Hs	biological process
innate immune response	Hs	biological process
positive regulation of JNK cascade	Hs	biological process
regulation of inflammatory response	Hs	biological process
defense response to Gram-positive bacterium	Hs	biological process
positive regulation of NF-kappaB transcription factor activity	Hs	biological process
interleukin-1-mediated signaling pathway	Hs	biological process
3'-UTR-mediated mRNA stabilization	Hs	biological process
TIR domain binding	Hs	molecular function
cellular response to mechanical stimulus	Hs	biological process
establishment of endothelial intestinal barrier	Hs	biological process
regulation of neutrophil migration	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
Golgi membrane	Hs	cellular component	43.1	3.06e-04
RNA binding	Hs	molecular function	43.1	3.06e-04
double-stranded RNA binding	Hs	molecular function	43.1	3.06e-04
receptor activity	Hs	molecular function	43.1	3.06e-04
transmembrane signaling receptor activity	Hs	molecular function	43.1	3.06e-04
receptor binding	Hs	molecular function	113	2.13e-28
Toll binding	Hs	molecular function	113	2.13e-28
death receptor binding	Hs	molecular function	113	2.13e-28
interleukin-1 receptor binding	Hs	molecular function	113	2.13e-28
protein binding	Hs	molecular function	113	2.13e-28
intracellular	Hs	cellular component	43.1	3.06e-04
nucleus	Hs	cellular component	113	2.13e-28
cytoplasm	Hs	cellular component	113	2.13e-28
lysosomal membrane	Hs	cellular component	43.1	3.06e-04
endosome	Hs	cellular component	43.1	3.06e-04
early endosome	Hs	cellular component	43.1	3.06e-04
endoplasmic reticulum	Hs	cellular component	43.1	3.06e-04
endoplasmic reticulum membrane	Hs	cellular component	43.1	3.06e-04
cytosol	Hs	cellular component	113	2.13e-28
plasma membrane	Hs	cellular component	113	2.13e-28
integral component of plasma membrane	Hs	cellular component	43.1	3.06e-04
endosome membrane	Hs	cellular component	113	2.13e-28
postsynaptic density	Hs	cellular component	113	2.13e-28
membrane	Hs	cellular component	44.3	1.12e-04
integral component of membrane	Hs	cellular component	44.3	1.12e-04
Toll-like receptor binding	Hs	molecular function	113	2.13e-28
endolysosome membrane	Hs	cellular component	43.1	3.06e-04
identical protein binding	Hs	molecular function	113	2.13e-28
protein self-association	Hs	molecular function	113	2.13e-28
TIR domain binding	Hs	molecular function	113	2.13e-28

GO Term	Analysis	Type	e-value
MyD88-dependent toll-like receptor signaling pathway	PANTHER	biological process	1.7E-34
protein binding	Pfam	molecular function	6.3E-11
signal transduction	Pfam	biological process	6.3E-11
positive regulation of I-kappaB kinase/NF-kappaB signaling	PANTHER	biological process	1.7E-34
TIR domain binding	PANTHER	molecular function	1.7E-34