IPR Term	Analysis	Definition
TGF-beta-rel	PANTHER	Transforming growth factor-beta-related
TGF-b_C	SMART	Transforming growth factor-beta, C-terminal
Cystine-knot_cytokine	Gene3D	Cystine-knot cytokine
TGF-b_C	Pfam	Transforming growth factor-beta, C-terminal
TGFb_CS	ProSitePatterns	Transforming growth factor beta, conserved site
TGF-b_C	ProSiteProfiles	Transforming growth factor-beta, C-terminal
TGF-b_propeptide	Pfam	TGF-beta, propeptide
Cystine-knot_cytokine	SUPERFAMILY	Cystine-knot cytokine

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
protein binding	Orthology	molecular function
extracellular region	Orthology	cellular component
extracellular space	Orthology	cellular component
cytoplasm	Orthology	cellular component
immune response	Orthology	biological process
multicellular organism development	Orthology	biological process
axon guidance	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process
positive regulation of cell death	Orthology	biological process
cell differentiation	Orthology	biological process
vesicle	Orthology	cellular component
regulation of apoptotic process	Orthology	biological process
positive regulation of apoptotic process	Orthology	biological process
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
protein heterodimerization activity	Orthology	molecular function
cell development	Orthology	biological process
anatomical structure formation involved in morphogenesis	Orthology	biological process
neuron projection morphogenesis	Orthology	biological process
negative regulation of cell death	Orthology	biological process
system development	Orthology	biological process
animal organ development	Orthology	biological process
positive regulation of cell proliferation	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
heart development	Orthology	biological process
receptor binding	Orthology	molecular function
molecular function regulator	Orthology	molecular function
regulation of signal transduction	Orthology	biological process
signaling receptor activity	Orthology	molecular function
cellular process	Orthology	biological process
cell	Orthology	cellular component
defense response	Orthology	biological process
anion binding	Orthology	molecular function
carbohydrate derivative binding	Orthology	molecular function
regulation of molecular function	Orthology	biological process
protein phosphorylation	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
response to stimulus	Orthology	biological process
neuron projection development	Orthology	biological process
regulation of transcription from RNA polymerase II promoter	Orthology	biological process
cellular response to organic substance	Orthology	biological process
reproductive process	Orthology	biological process
anatomical structure development	Orthology	biological process
brain development	Orthology	biological process
extracellular region part	Orthology	cellular component
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
response to lipid	Orthology	biological process
cell adhesion	Orthology	biological process
protein localization to organelle	Orthology	biological process
phosphorylation	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
signal transduction	Orthology	biological process
regulation of catalytic activity	Orthology	biological process
intracellular signal transduction	Orthology	biological process
protein serine/threonine kinase activity	Orthology	molecular function
negative regulation of signal transduction	Orthology	biological process
response to organic substance	Orthology	biological process
neuron differentiation	Orthology	biological process
Notch signaling pathway	Orthology	biological process
cell cycle	Orthology	biological process
protein transport	Orthology	biological process
generation of neurons	Orthology	biological process
response to hypoxia	Orthology	biological process
cellular response to stress	Orthology	biological process
head development	Orthology	biological process
negative regulation of apoptotic process	Orthology	biological process
cell-cell signaling	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
skeletal system development	Hs	biological process
ossification	Hs	biological process
osteoblast differentiation	Hs	biological process
eye development	Hs	biological process
ureteric bud development	Hs	biological process
mesoderm formation	Hs	biological process
kidney development	Hs	biological process
epithelial to mesenchymal transition	Hs	biological process
positive regulation of endothelial cell proliferation	Hs	biological process
endochondral ossification	Hs	biological process
endocardial cushion formation	Hs	biological process
type B pancreatic cell development	Hs	biological process
pericardium morphogenesis	Hs	biological process
cytokine activity	Hs	molecular function
transforming growth factor beta receptor binding	Hs	molecular function
protein binding	Hs	molecular function
extracellular region	Hs	cellular component
extracellular space	Hs	cellular component
cytoplasm	Hs	cellular component
cellular iron ion homeostasis	Hs	biological process
inflammatory response	Hs	biological process
immune response	Hs	biological process
multicellular organism development	Hs	biological process
pattern specification process	Hs	biological process
axon guidance	Hs	biological process
salivary gland morphogenesis	Hs	biological process
growth factor activity	Hs	molecular function
heparin binding	Hs	molecular function
negative regulation of cell proliferation	Hs	biological process
embryonic pattern specification	Hs	biological process
animal organ morphogenesis	Hs	biological process
response to iron ion	Hs	biological process
regulation of receptor activity	Hs	biological process
positive regulation of epithelial to mesenchymal transition	Hs	biological process
negative regulation of epithelial to mesenchymal transition	Hs	biological process
positive regulation of peptidyl-threonine phosphorylation	Hs	biological process
positive regulation of pathway-restricted SMAD protein phosphorylation	Hs	biological process
positive regulation of cell death	Hs	biological process
response to activity	Hs	biological process
dendrite development	Hs	biological process
cell differentiation	Hs	biological process
embryonic limb morphogenesis	Hs	biological process
positive regulation of bone mineralization	Hs	biological process
BMP signaling pathway	Hs	biological process
male genitalia development	Hs	biological process
epithelial cell differentiation	Hs	biological process
hindbrain development	Hs	biological process
extracellular matrix	Hs	cellular component
vesicle	Hs	cellular component
response to magnesium ion	Hs	biological process
negative regulation of NF-kappaB transcription factor activity	Hs	biological process
positive regulation of chondrocyte differentiation	Hs	biological process
response to estradiol	Hs	biological process
response to retinoic acid	Hs	biological process
positive regulation of heterotypic cell-cell adhesion	Hs	biological process
protein localization to nucleus	Hs	biological process
tube morphogenesis	Hs	biological process
regulation of phosphorylation	Hs	biological process
negative regulation of phosphorylation	Hs	biological process
regulation of apoptotic process	Hs	biological process
positive regulation of apoptotic process	Hs	biological process
steroid hormone mediated signaling pathway	Hs	biological process
negative regulation of MAP kinase activity	Hs	biological process
regulation of MAPK cascade	Hs	biological process
response to peptide hormone	Hs	biological process
negative regulation of insulin-like growth factor receptor signaling pathway	Hs	biological process
ear development	Hs	biological process
positive regulation of cell differentiation	Hs	biological process
positive regulation of endothelial cell differentiation	Hs	biological process
negative regulation of neuron differentiation	Hs	biological process
positive regulation of neuron differentiation	Hs	biological process
positive regulation of osteoblast differentiation	Hs	biological process
negative regulation of Notch signaling pathway	Hs	biological process
negative regulation of cell cycle	Hs	biological process
negative regulation of mitotic nuclear division	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
protein heterodimerization activity	Hs	molecular function
cell development	Hs	biological process
camera-type eye morphogenesis	Hs	biological process
embryonic camera-type eye morphogenesis	Hs	biological process
anatomical structure formation involved in morphogenesis	Hs	biological process
cardiac muscle tissue development	Hs	biological process
branching morphogenesis of an epithelial tube	Hs	biological process
neuron projection morphogenesis	Hs	biological process
positive regulation of epithelial cell proliferation	Hs	biological process
positive regulation of protein secretion	Hs	biological process
negative regulation of neurogenesis	Hs	biological process
cartilage development	Hs	biological process
response to glucocorticoid	Hs	biological process
pharyngeal system development	Hs	biological process
embryonic skeletal joint morphogenesis	Hs	biological process
SMAD protein signal transduction	Hs	biological process
negative regulation of cell death	Hs	biological process
multicellular organismal iron ion homeostasis	Hs	biological process
BMP receptor binding	Hs	molecular function
cellular response to mechanical stimulus	Hs	biological process
cellular response to hypoxia	Hs	biological process
anterior head development	Hs	biological process
positive regulation of dendrite development	Hs	biological process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Hs	biological process
negative regulation of insulin secretion	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
cytokine activity	Hs	molecular function	308	5.62e-99
transforming growth factor beta receptor binding	Hs	molecular function	308	5.62e-99
protein binding	Hs	molecular function	308	5.62e-99
extracellular region	Hs	cellular component	308	5.62e-99
extracellular space	Hs	cellular component	308	5.62e-99
cytoplasm	Hs	cellular component	166	9.92e-45
growth factor activity	Hs	molecular function	308	5.62e-99
heparin binding	Hs	molecular function	308	5.62e-99
extracellular matrix	Hs	cellular component	308	5.62e-99
vesicle	Hs	cellular component	308	5.62e-99
protein heterodimerization activity	Hs	molecular function	166	9.92e-45
BMP receptor binding	Hs	molecular function	308	5.62e-99

GO Term	Analysis	Type	e-value
growth factor activity	SMART	molecular function	6.7E-61