IPR Term	Analysis	Definition
Fumarase/histidase_N	Gene3D	Fumarase/histidase, N-terminal
Fum_hydII	PANTHER	Fumarate hydratase, class II
Fumarate_lyase_fam	PRINTS	Fumarate lyase family
Fumarase_C_C	Pfam	Fumarase C, C-terminal
Fumarate_lyase_CS	ProSitePatterns	Fumarate lyase, conserved site
Fum_hydII	CDD	Fumarate hydratase, class II
L-Aspartase-like	SUPERFAMILY	L-Aspartase-like
Fumarate_lyase_N	Pfam	Fumarate lyase, N-terminal
Fum_hydII	Hamap	Fumarate hydratase, class II

GO Term	Annotation Origin	Type
catalytic activity	Orthology	molecular function
protein binding	Orthology	molecular function
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
mitochondrial matrix	Orthology	cellular component
cytosol	Blast	cellular component
extracellular exosome	Orthology	cellular component
oxidation-reduction process	Orthology	biological process
cellular metabolic process	Orthology	biological process
organic substance metabolic process	Orthology	biological process
cytoplasmic part	Orthology	cellular component
macromolecular complex	Orthology	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
catalytic activity	Hs	molecular function
fumarate hydratase activity	Hs	molecular function
protein binding	Hs	molecular function
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
mitochondrial matrix	Hs	cellular component
tricarboxylic acid cycle	Hs	biological process
fumarate metabolic process	Hs	biological process
malate metabolic process	Hs	biological process
lyase activity	Hs	molecular function
tricarboxylic acid cycle enzyme complex	Hs	cellular component
homeostasis of number of cells within a tissue	Hs	biological process
extracellular exosome	Hs	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
catalytic activity	Hs	molecular function	667	0.0
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	Hs	molecular function	38.9	0.008
fumarate hydratase activity	Hs	molecular function	667	0.0
protein binding	Hs	molecular function	667	0.0
cytoplasm	Hs	cellular component	667	0.0
mitochondrion	Hs	cellular component	667	0.0
mitochondrial matrix	Hs	cellular component	667	0.0
cytosol	Hs	cellular component	38.9	0.008
lyase activity	Hs	molecular function	667	0.0
tricarboxylic acid cycle enzyme complex	Hs	cellular component	667	0.0
extracellular exosome	Hs	cellular component	667	0.0
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity	Hs	molecular function	38.9	0.008

GO Term	Analysis	Type	e-value
catalytic activity	SUPERFAMILY	molecular function	3.77E-125
fumarate hydratase activity	CDD	molecular function	0.0
tricarboxylic acid cycle	Pfam	biological process	5.5E-27
fumarate metabolic process	CDD	biological process	0.0
lyase activity	Pfam	molecular function	5.5E-27
tricarboxylic acid cycle enzyme complex	CDD	cellular component	0.0