IPR Term	Analysis	Definition
CRIB_dom_sf	Gene3D	CRIB domain superfamily
CRIB_dom	ProSiteProfiles	CRIB domain
Prot_kinase_dom	Pfam	Protein kinase domain
Prot_kinase_dom	SMART	Protein kinase domain
Protein_kinase_ATP_BS	ProSitePatterns	Protein kinase, ATP binding site
CRIB_dom	SMART	CRIB domain
Ser/Thr_kinase_AS	ProSitePatterns	Serine/threonine-protein kinase, active site
Kinase-like_dom_sf	SUPERFAMILY	Protein kinase-like domain superfamily
Prot_kinase_dom	ProSiteProfiles	Protein kinase domain
CRIB_dom	Pfam	CRIB domain
PAK_BD	CDD	p21 activated kinase binding domain

GO Term	Annotation Origin	Type
nucleotide binding	Orthology	molecular function
response to hypoxia	Orthology	biological process
catalytic activity	Orthology	molecular function
protein kinase activity	Orthology	molecular function
protein serine/threonine kinase activity	Orthology	molecular function
protein binding	Orthology	molecular function
ATP binding	Orthology	molecular function
nucleus	Orthology	cellular component
cytoplasm	Orthology	cellular component
endosome	Orthology	cellular component
cytosol	Orthology	cellular component
plasma membrane	Orthology	cellular component
focal adhesion	Orthology	cellular component
protein phosphorylation	Orthology	biological process
apoptotic process	Orthology	biological process
signal transduction	Orthology	biological process
multicellular organism development	Orthology	biological process
axonogenesis	Orthology	biological process
metabolic process	Orthology	biological process
positive regulation of cell proliferation	Orthology	biological process
response to organic substance	Orthology	biological process
membrane	Orthology	cellular component
kinase activity	Orthology	molecular function
phosphorylation	Orthology	biological process
cell migration	Orthology	biological process
transferase activity	Orthology	molecular function
protein kinase binding	Orthology	molecular function
lamellipodium	Orthology	cellular component
cell junction	Orthology	cellular component
axon	Orthology	cellular component
nuclear membrane	Orthology	cellular component
macromolecular complex	Orthology	cellular component
wound healing	Orthology	biological process
identical protein binding	Orthology	molecular function
regulation of apoptotic process	Orthology	biological process
cell projection	Orthology	cellular component
negative regulation of apoptotic process	Orthology	biological process
protein autophosphorylation	Orthology	biological process
metal ion binding	Orthology	molecular function
perinuclear region of cytoplasm	Orthology	cellular component
neuron projection morphogenesis	Orthology	biological process
intracellular signal transduction	Orthology	biological process
positive regulation of catalytic activity	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
plasma membrane region	Orthology	cellular component
cell leading edge	Orthology	cellular component
macromolecular complex binding	Orthology	molecular function
regulation of catalytic activity	Orthology	biological process
membrane organization	Orthology	biological process
organelle organization	Orthology	biological process
small GTPase mediated signal transduction	Orthology	biological process
neuron projection development	Orthology	biological process
enzyme binding	Orthology	molecular function
brain development	Orthology	biological process
cellular process	Orthology	biological process
organelle part	Orthology	cellular component
cytoplasmic part	Orthology	cellular component
intracellular non-membrane-bounded organelle	Orthology	cellular component
enzyme activator activity	Orthology	molecular function
cellular response to stress	Orthology	biological process
microtubule-based process	Orthology	biological process
cytoskeletal part	Orthology	cellular component
cell projection membrane	Orthology	cellular component
cellular response to organic substance	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
immune response	Orthology	biological process
regulation of signal transduction	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
positive regulation of apoptotic process	Orthology	biological process
cell adhesion molecule binding	Orthology	molecular function
anatomical structure morphogenesis	Orthology	biological process
cellular component organization	Orthology	biological process
cell morphogenesis involved in neuron differentiation	Orthology	biological process
protein targeting to membrane	Orthology	biological process
endopeptidase activity	Orthology	molecular function
cell projection assembly	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
MAPK cascade	Hs	biological process
nucleotide binding	Hs	molecular function
activation of MAPK activity	Hs	biological process
response to hypoxia	Hs	biological process
ruffle	Hs	cellular component
positive regulation of protein phosphorylation	Hs	biological process
catalytic activity	Hs	molecular function
protein kinase activity	Hs	molecular function
protein serine/threonine kinase activity	Hs	molecular function
MAP kinase kinase activity	Hs	molecular function
protein binding	Hs	molecular function
collagen binding	Hs	molecular function
ATP binding	Hs	molecular function
nucleus	Hs	cellular component
cytoplasm	Hs	cellular component
endosome	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
cell-cell junction	Hs	cellular component
focal adhesion	Hs	cellular component
protein phosphorylation	Hs	biological process
negative regulation of protein kinase activity	Hs	biological process
exocytosis	Hs	biological process
apoptotic process	Hs	biological process
signal transduction	Hs	biological process
Rho protein signal transduction	Hs	biological process
multicellular organism development	Hs	biological process
regulation of mitotic cell cycle	Hs	biological process
axonogenesis	Hs	biological process
metabolic process	Hs	biological process
positive regulation of cell proliferation	Hs	biological process
response to organic substance	Hs	biological process
regulation of neuron projection development	Hs	biological process
intercalated disc	Hs	cellular component
membrane	Hs	cellular component
viral process	Hs	biological process
kinase activity	Hs	molecular function
phosphorylation	Hs	biological process
dendrite development	Hs	biological process
cell migration	Hs	biological process
transferase activity	Hs	molecular function
Rho GTPase binding	Hs	molecular function
SH3 domain binding	Hs	molecular function
peptidyl-serine phosphorylation	Hs	biological process
protein kinase binding	Hs	molecular function
cerebellum development	Hs	biological process
signal transduction by protein phosphorylation	Hs	biological process
establishment of cell polarity	Hs	biological process
Z disc	Hs	cellular component
lamellipodium	Hs	cellular component
actin cytoskeleton organization	Hs	biological process
cell junction	Hs	cellular component
protein tyrosine kinase activator activity	Hs	molecular function
positive regulation of cell migration	Hs	biological process
axon	Hs	cellular component
dendrite	Hs	cellular component
regulation of actin filament polymerization	Hs	biological process
stress-activated protein kinase signaling cascade	Hs	biological process
positive regulation of microtubule polymerization	Hs	biological process
small GTPase binding	Hs	molecular function
actin cytoskeleton reorganization	Hs	biological process
filamentous actin	Hs	cellular component
nuclear membrane	Hs	cellular component
activation of protein kinase activity	Hs	biological process
ruffle membrane	Hs	cellular component
cellular response to insulin stimulus	Hs	biological process
regulation of actin cytoskeleton organization	Hs	biological process
macromolecular complex	Hs	cellular component
positive regulation of peptidyl-serine phosphorylation	Hs	biological process
Fc-epsilon receptor signaling pathway	Hs	biological process
regulation of growth	Hs	biological process
wound healing	Hs	biological process
identical protein binding	Hs	molecular function
regulation of apoptotic process	Hs	biological process
cell projection	Hs	cellular component
negative regulation of apoptotic process	Hs	biological process
regulation of MAPK cascade	Hs	biological process
positive regulation of JUN kinase activity	Hs	biological process
positive regulation of neuron apoptotic process	Hs	biological process
cadherin binding	Hs	molecular function
positive regulation of axon extension	Hs	biological process
protein autophosphorylation	Hs	biological process
metal ion binding	Hs	molecular function
vascular endothelial growth factor receptor signaling pathway	Hs	biological process
hepatocyte growth factor receptor signaling pathway	Hs	biological process
ephrin receptor signaling pathway	Hs	biological process
Rac GTPase binding	Hs	molecular function
perinuclear region of cytoplasm	Hs	cellular component
branching morphogenesis of an epithelial tube	Hs	biological process
neuron projection morphogenesis	Hs	biological process
positive regulation of peptidyl-tyrosine phosphorylation	Hs	biological process
regulation of axonogenesis	Hs	biological process
synapse organization	Hs	biological process
T cell receptor signaling pathway	Hs	biological process
GTPase binding	Hs	molecular function
positive regulation of stress fiber assembly	Hs	biological process
dendritic spine development	Hs	biological process
dendritic spine morphogenesis	Hs	biological process
positive regulation of dendritic spine morphogenesis	Hs	biological process
positive regulation of protein tyrosine kinase activity	Hs	biological process
cellular response to organic cyclic compound	Hs	biological process
invadopodium	Hs	cellular component
positive regulation of protein targeting to membrane	Hs	biological process
positive regulation of extrinsic apoptotic signaling pathway	Hs	biological process
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nucleotide binding	Hs	molecular function	707	0.0
ruffle	Hs	cellular component	692	0.0
catalytic activity	Hs	molecular function	707	0.0
protein kinase activity	Hs	molecular function	707	0.0
protein serine/threonine kinase activity	Hs	molecular function	707	0.0
MAP kinase kinase activity	Hs	molecular function	707	0.0
protein binding	Hs	molecular function	707	0.0
collagen binding	Hs	molecular function	692	0.0
ATP binding	Hs	molecular function	707	0.0
nucleus	Hs	cellular component	673	0.0
cytoplasm	Hs	cellular component	707	0.0
endosome	Hs	cellular component	707	0.0
cytosol	Hs	cellular component	707	0.0
plasma membrane	Hs	cellular component	707	0.0
cell-cell junction	Hs	cellular component	692	0.0
focal adhesion	Hs	cellular component	692	0.0
intercalated disc	Hs	cellular component	692	0.0
membrane	Hs	cellular component	692	0.0
kinase activity	Hs	molecular function	707	0.0
transferase activity	Hs	molecular function	707	0.0
Rho GTPase binding	Hs	molecular function	707	0.0
SH3 domain binding	Hs	molecular function	707	0.0
protein kinase binding	Hs	molecular function	692	0.0
Z disc	Hs	cellular component	692	0.0
lamellipodium	Hs	cellular component	692	0.0
cell junction	Hs	cellular component	692	0.0
protein tyrosine kinase activator activity	Hs	molecular function	673	0.0
axon	Hs	cellular component	692	0.0
dendrite	Hs	cellular component	692	0.0
small GTPase binding	Hs	molecular function	673	0.0
filamentous actin	Hs	cellular component	692	0.0
nuclear membrane	Hs	cellular component	692	0.0
ruffle membrane	Hs	cellular component	692	0.0
macromolecular complex	Hs	cellular component	692	0.0
identical protein binding	Hs	molecular function	673	0.0
cell projection	Hs	cellular component	692	0.0
cadherin binding	Hs	molecular function	673	0.0
metal ion binding	Hs	molecular function	707	0.0
Rac GTPase binding	Hs	molecular function	707	0.0
perinuclear region of cytoplasm	Hs	cellular component	673	0.0
GTPase binding	Hs	molecular function	707	0.0
invadopodium	Hs	cellular component	692	0.0

GO Term	Analysis	Type	e-value
protein kinase activity	SMART	molecular function	3.1E-97
protein serine/threonine kinase activity	CDD	molecular function	2.79526E-24
ATP binding	SMART	molecular function	3.1E-97
protein phosphorylation	SMART	biological process	3.1E-97