IPR Term	Analysis	Definition
WH_DNA-bd_sf	SUPERFAMILY	Winged helix DNA-binding domain superfamily
TPR-like_helical_dom_sf	SUPERFAMILY	Tetratricopeptide-like helical domain superfamily
PCI_dom	SMART	Proteasome component (PCI) domain
Rpn7/CSN1	Pfam	26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1
PSMD6	PANTHER	26S Proteasome non-ATPase regulatory subunit 6
PCI_dom	ProSiteProfiles	Proteasome component (PCI) domain
PCI_dom	Pfam	Proteasome component (PCI) domain

GO Term	Annotation Origin	Type
protein polyubiquitination	Orthology	biological process
protein binding	Orthology	molecular function
extracellular region	Orthology	cellular component
nucleus	Blast	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Blast	cellular component
cytosol	Orthology	cellular component
proteolysis	Orthology	biological process
enzyme regulator activity	Orthology	molecular function
regulation of catalytic activity	Orthology	biological process
transmembrane transport	Orthology	biological process
extracellular exosome	Orthology	cellular component
negative regulation of canonical Wnt signaling pathway	Orthology	biological process
positive regulation of canonical Wnt signaling pathway	Orthology	biological process
intracellular signal transduction	Orthology	biological process
protein phosphorylation	Orthology	biological process
intracellular part	Orthology	cellular component
macromolecular complex	Orthology	cellular component
G2/M transition of mitotic cell cycle	Orthology	biological process
peptidase activity, acting on L-amino acid peptides	Orthology	molecular function
nucleoside-triphosphatase activity	Orthology	molecular function
cytokine-mediated signaling pathway	Orthology	biological process
intracellular organelle part	Orthology	cellular component
cytoplasmic vesicle	Orthology	cellular component
endomembrane system	Orthology	cellular component
intracellular organelle lumen	Orthology	cellular component
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
cell surface receptor signaling pathway	Orthology	biological process
immune response	Orthology	biological process
mRNA catabolic process	Orthology	biological process
cellular protein modification process	Orthology	biological process
cell-cell signaling	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
animal organ development	Orthology	biological process
immune system process	Orthology	biological process
cell differentiation	Orthology	biological process
regulation of GTPase activity	Blast	biological process
GTPase regulator activity	Blast	molecular function
nuclear part	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
MAPK cascade	Hs	biological process
protein polyubiquitination	Hs	biological process
proteasome complex	Hs	cellular component
protein binding	Hs	molecular function
extracellular region	Hs	cellular component
nucleoplasm	Hs	cellular component
cytosol	Hs	cellular component
proteasome regulatory particle	Hs	cellular component
proteolysis	Hs	biological process
negative regulation of G2/M transition of mitotic cell cycle	Hs	biological process
protein deubiquitination	Hs	biological process
ATPase activity	Hs	molecular function
proteasome accessory complex	Hs	cellular component
enzyme regulator activity	Hs	molecular function
anaphase-promoting complex-dependent catabolic process	Hs	biological process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Hs	biological process
tumor necrosis factor-mediated signaling pathway	Hs	biological process
secretory granule lumen	Hs	cellular component
NIK/NF-kappaB signaling	Hs	biological process
Fc-epsilon receptor signaling pathway	Hs	biological process
proteasome-mediated ubiquitin-dependent protein catabolic process	Hs	biological process
regulation of mRNA stability	Hs	biological process
post-translational protein modification	Hs	biological process
regulation of catalytic activity	Hs	biological process
T cell receptor signaling pathway	Hs	biological process
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Hs	biological process
transmembrane transport	Hs	biological process
Wnt signaling pathway, planar cell polarity pathway	Hs	biological process
extracellular exosome	Hs	cellular component
interleukin-1-mediated signaling pathway	Hs	biological process
negative regulation of canonical Wnt signaling pathway	Hs	biological process
positive regulation of canonical Wnt signaling pathway	Hs	biological process
regulation of hematopoietic stem cell differentiation	Hs	biological process
ficolin-1-rich granule lumen	Hs	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
proteasome complex	Hs	cellular component	526	0.0
GTPase inhibitor activity	Hs	molecular function	86.3	2.37e-18
protein binding	Hs	molecular function	526	0.0
extracellular region	Hs	cellular component	526	0.0
nucleus	Hs	cellular component	86.3	2.37e-18
nucleoplasm	Hs	cellular component	526	0.0
cytoplasm	Hs	cellular component	86.3	2.37e-18
cytosol	Hs	cellular component	526	0.0
proteasome regulatory particle	Hs	cellular component	526	0.0
COP9 signalosome	Hs	cellular component	86.3	2.37e-18
ATPase activity	Hs	molecular function	526	0.0
proteasome accessory complex	Hs	cellular component	526	0.0
enzyme regulator activity	Hs	molecular function	526	0.0
secretory granule lumen	Hs	cellular component	526	0.0
extracellular exosome	Hs	cellular component	526	0.0
ficolin-1-rich granule lumen	Hs	cellular component	526	0.0

GO Term	Analysis	Type	e-value
protein binding	SMART	molecular function	1.7E-23
enzyme regulator activity	PANTHER	molecular function	1.9E-173