IPR Term	Analysis	Definition
14-3-3	PANTHER	14-3-3 protein
14-3-3_CS	ProSitePatterns	14-3-3 protein, conserved site
14-3-3	PIRSF	14-3-3 protein
14-3-3	PRINTS	14-3-3 protein
14-3-3_dom_sf	Gene3D	14-3-3 domain superfamily
14-3-3_dom_sf	SUPERFAMILY	14-3-3 domain superfamily
14-3-3_domain	Pfam	14-3-3 domain
14-3-3_domain	SMART	14-3-3 domain

GO Term	Annotation Origin	Type
G2/M transition of mitotic cell cycle	Orthology	biological process
transcription corepressor activity	Orthology	molecular function
RNA binding	Orthology	molecular function
protein binding	Orthology	molecular function
extracellular space	Orthology	cellular component
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
cytosol	Orthology	cellular component
focal adhesion	Orthology	cellular component
protein targeting	Orthology	biological process
signal transduction	Orthology	biological process
protein C-terminus binding	Orthology	molecular function
transcription factor binding	Orthology	molecular function
regulation of signal transduction	Orthology	biological process
membrane	Orthology	cellular component
kinase activity	Orthology	molecular function
phosphorylation	Orthology	biological process
cytokine-mediated signaling pathway	Orthology	biological process
enzyme binding	Orthology	molecular function
protein kinase binding	Orthology	molecular function
ubiquitin protein ligase binding	Orthology	molecular function
vesicle	Orthology	cellular component
melanosome	Orthology	cellular component
identical protein binding	Orthology	molecular function
negative regulation of apoptotic process	Orthology	biological process
positive regulation of catalytic activity	Orthology	biological process
myelin sheath	Orthology	cellular component
negative regulation of transcription, DNA-templated	Orthology	biological process
perinuclear region of cytoplasm	Orthology	cellular component
oxidation-reduction process	Orthology	biological process
membrane organization	Orthology	biological process
extracellular exosome	Orthology	cellular component
actin binding	Orthology	molecular function
extracellular region	Orthology	cellular component
plasma membrane	Orthology	cellular component
intracellular protein transport	Orthology	biological process
macromolecular complex	Orthology	cellular component
positive regulation of transcription, DNA-templated	Orthology	biological process
protein heterodimerization activity	Orthology	molecular function
protein N-terminus binding	Orthology	molecular function
intracellular signal transduction	Orthology	biological process
protein phosphorylation	Orthology	biological process
catalytic activity	Orthology	molecular function
receptor binding	Orthology	molecular function
regulation of catalytic activity	Orthology	biological process
protein kinase activity	Orthology	molecular function
enzyme regulator activity	Orthology	molecular function
protein serine/threonine kinase activity	Orthology	molecular function
blood coagulation	Orthology	biological process
cellular process	Orthology	biological process
intracellular organelle part	Orthology	cellular component
organelle membrane	Orthology	cellular component
cytoplasmic vesicle	Orthology	cellular component
cellular response to organic substance	Orthology	biological process
protein dephosphorylation	Orthology	biological process
mRNA catabolic process	Orthology	biological process
cell adhesion molecule binding	Orthology	molecular function
cell development	Orthology	biological process
neuron differentiation	Orthology	biological process
chemical synaptic transmission	Orthology	biological process
regulation of signaling	Orthology	biological process
protein oligomerization	Orthology	biological process
cell cycle	Orthology	biological process
molecular transducer activity	Orthology	molecular function
regulation of cellular metabolic process	Orthology	biological process
organelle organization	Orthology	biological process
apoptotic process	Orthology	biological process
sodium ion transport	Orthology	biological process
animal organ development	Orthology	biological process
cellular response to DNA damage stimulus	Orthology	biological process
cell junction	Orthology	cellular component
molecular function regulator	Orthology	molecular function
transmembrane transport	Orthology	biological process
cell differentiation	Orthology	biological process
cellular component organization	Orthology	biological process
response to lipid	Orthology	biological process
endopeptidase activity	Orthology	molecular function
cell morphogenesis involved in neuron differentiation	Orthology	biological process
neuron projection morphogenesis	Orthology	biological process
regulation of molecular function	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
G2/M transition of mitotic cell cycle	Hs	biological process
MAPK cascade	Hs	biological process
transcription corepressor activity	Hs	molecular function
RNA binding	Hs	molecular function
monooxygenase activity	Hs	molecular function
protein kinase C binding	Hs	molecular function
insulin-like growth factor receptor binding	Hs	molecular function
protein binding	Hs	molecular function
extracellular space	Hs	cellular component
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
cytosol	Hs	cellular component
focal adhesion	Hs	cellular component
negative regulation of protein kinase activity	Hs	biological process
protein targeting	Hs	biological process
signal transduction	Hs	biological process
protein C-terminus binding	Hs	molecular function
transcription factor binding	Hs	molecular function
protein kinase C inhibitor activity	Hs	molecular function
regulation of signal transduction	Hs	biological process
regulation of G2/M transition of mitotic cell cycle	Hs	biological process
membrane	Hs	cellular component
viral process	Hs	biological process
kinase activity	Hs	molecular function
phosphorylation	Hs	biological process
transcriptional repressor complex	Hs	cellular component
cytokine-mediated signaling pathway	Hs	biological process
enzyme binding	Hs	molecular function
protein kinase binding	Hs	molecular function
protein domain specific binding	Hs	molecular function
platelet activation	Hs	biological process
cytoplasmic vesicle membrane	Hs	cellular component
receptor tyrosine kinase binding	Hs	molecular function
ubiquitin protein ligase binding	Hs	molecular function
vesicle	Hs	cellular component
cellular response to insulin stimulus	Hs	biological process
negative regulation of protein dephosphorylation	Hs	biological process
hippo signaling	Hs	biological process
melanosome	Hs	cellular component
identical protein binding	Hs	molecular function
histone deacetylase binding	Hs	molecular function
negative regulation of apoptotic process	Hs	biological process
positive regulation of catalytic activity	Hs	biological process
myelin sheath	Hs	cellular component
regulation of mRNA stability	Hs	biological process
ion channel binding	Hs	molecular function
cadherin binding	Hs	molecular function
regulation of neuron differentiation	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
regulation of synaptic plasticity	Hs	biological process
perinuclear region of cytoplasm	Hs	cellular component
phosphoserine residue binding	Hs	molecular function
phosphoprotein binding	Hs	molecular function
protein heterooligomerization	Hs	biological process
establishment of Golgi localization	Hs	biological process
oxidation-reduction process	Hs	biological process
membrane organization	Hs	biological process
extracellular exosome	Hs	cellular component
negative regulation of protein serine/threonine kinase activity	Hs	biological process
blood microparticle	Hs	cellular component
regulation of cyclin-dependent protein serine/threonine kinase activity	Hs	biological process
release of cytochrome c from mitochondria	Hs	biological process
regulation of sodium ion transport	Hs	biological process
keratinocyte development	Hs	biological process
actin binding	Hs	molecular function
extracellular region	Hs	cellular component
plasma membrane	Hs	cellular component
intracellular protein transport	Hs	biological process
intrinsic apoptotic signaling pathway in response to DNA damage	Hs	biological process
intercalated disc	Hs	cellular component
sodium channel regulator activity	Hs	molecular function
keratinocyte differentiation	Hs	biological process
positive regulation of cell growth	Hs	biological process
macromolecular complex	Hs	cellular component
glucocorticoid receptor binding	Hs	molecular function
glucocorticoid receptor signaling pathway	Hs	biological process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Hs	biological process
skin development	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
positive regulation of protein export from nucleus	Hs	biological process
protein heterodimerization activity	Hs	molecular function
protein N-terminus binding	Hs	molecular function
negative regulation of dendrite morphogenesis	Hs	biological process
regulation of cell cycle	Hs	biological process
establishment of skin barrier	Hs	biological process
membrane depolarization during action potential	Hs	biological process
regulation of sodium ion transmembrane transporter activity	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
transcription corepressor activity	Hs	molecular function	324	4.29e-113
RNA binding	Hs	molecular function	327	3.74e-114
monooxygenase activity	Hs	molecular function	327	3.74e-114
protein kinase C binding	Hs	molecular function	322	3.29e-112
insulin-like growth factor receptor binding	Hs	molecular function	322	3.29e-112
protein binding	Hs	molecular function	327	3.74e-114
extracellular space	Hs	cellular component	327	3.74e-114
nucleus	Hs	cellular component	327	3.74e-114
nucleoplasm	Hs	cellular component	327	3.74e-114
cytoplasm	Hs	cellular component	327	3.74e-114
mitochondrion	Hs	cellular component	324	4.29e-113
cytosol	Hs	cellular component	327	3.74e-114
focal adhesion	Hs	cellular component	327	3.74e-114
protein C-terminus binding	Hs	molecular function	324	4.29e-113
transcription factor binding	Hs	molecular function	327	3.74e-114
protein kinase C inhibitor activity	Hs	molecular function	322	3.29e-112
membrane	Hs	cellular component	324	4.29e-113
kinase activity	Hs	molecular function	327	3.74e-114
transcriptional repressor complex	Hs	cellular component	324	4.29e-113
enzyme binding	Hs	molecular function	324	4.29e-113
protein kinase binding	Hs	molecular function	327	3.74e-114
protein domain specific binding	Hs	molecular function	327	3.74e-114
cytoplasmic vesicle membrane	Hs	cellular component	327	3.74e-114
receptor tyrosine kinase binding	Hs	molecular function	322	3.29e-112
ubiquitin protein ligase binding	Hs	molecular function	327	3.74e-114
vesicle	Hs	cellular component	327	3.74e-114
melanosome	Hs	cellular component	327	3.74e-114
identical protein binding	Hs	molecular function	327	3.74e-114
histone deacetylase binding	Hs	molecular function	324	4.29e-113
myelin sheath	Hs	cellular component	322	3.29e-112
ion channel binding	Hs	molecular function	327	3.74e-114
cadherin binding	Hs	molecular function	327	3.74e-114
perinuclear region of cytoplasm	Hs	cellular component	324	4.29e-113
phosphoserine residue binding	Hs	molecular function	324	4.29e-113
phosphoprotein binding	Hs	molecular function	324	4.29e-113
extracellular exosome	Hs	cellular component	327	3.74e-114
blood microparticle	Hs	cellular component	327	3.74e-114

GO Term	Analysis	Type	e-value
protein domain specific binding	PANTHER	molecular function	8.5E-115