IPR Term	Analysis	Definition
Kinase-like_dom_sf	SUPERFAMILY	Protein kinase-like domain superfamily
Prot_kinase_dom	ProSiteProfiles	Protein kinase domain
GS_dom	ProSiteProfiles	GS domain
Ser/Thr_kinase_AS	ProSitePatterns	Serine/threonine-protein kinase, active site
Prot_kinase_dom	SMART	Protein kinase domain
TGFB_receptor	PANTHER	Ser/Thr protein kinase, TGFB receptor
Prot_kinase_dom	Pfam	Protein kinase domain
GS_dom	SMART	GS domain
Protein_kinase_ATP_BS	ProSitePatterns	Protein kinase, ATP binding site
GS_dom	Pfam	GS domain

GO Term	Annotation Origin	Type
G1/S transition of mitotic cell cycle	Orthology	biological process
nucleotide binding	Orthology	molecular function
angiogenesis	Orthology	biological process
protein kinase activity	Orthology	molecular function
protein serine/threonine kinase activity	Orthology	molecular function
receptor binding	Orthology	molecular function
protein binding	Orthology	molecular function
ATP binding	Orthology	molecular function
cell	Orthology	cellular component
endosome	Orthology	cellular component
cytosol	Orthology	cellular component
plasma membrane	Orthology	cellular component
integral component of plasma membrane	Orthology	cellular component
regulation of transcription, DNA-templated	Orthology	biological process
protein phosphorylation	Orthology	biological process
apoptotic process	Orthology	biological process
signal transduction	Orthology	biological process
central nervous system development	Orthology	biological process
heart development	Orthology	biological process
positive regulation of cell proliferation	Orthology	biological process
regulation of signal transduction	Orthology	biological process
cell surface	Orthology	cellular component
regulation of gene expression	Orthology	biological process
positive regulation of gene expression	Orthology	biological process
negative regulation of gene expression	Orthology	biological process
membrane	Orthology	cellular component
integral component of membrane	Orthology	cellular component
kinase activity	Orthology	molecular function
phosphorylation	Orthology	biological process
transferase activity	Orthology	molecular function
cell junction	Orthology	cellular component
cell differentiation	Orthology	biological process
ubiquitin protein ligase binding	Orthology	molecular function
intracellular signal transduction	Orthology	biological process
wound healing	Orthology	biological process
positive regulation of apoptotic process	Orthology	biological process
negative regulation of apoptotic process	Orthology	biological process
intracellular membrane-bounded organelle	Orthology	cellular component
membrane raft	Orthology	cellular component
positive regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
protein autophosphorylation	Orthology	biological process
metal ion binding	Orthology	molecular function
cell motility	Orthology	biological process
extracellular exosome	Orthology	cellular component
positive regulation of catalytic activity	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
system development	Orthology	biological process
animal organ development	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
transmembrane signaling receptor activity	Orthology	molecular function
cellular response to organic substance	Orthology	biological process
cell migration	Orthology	biological process
gamete generation	Orthology	biological process
reproductive process	Orthology	biological process
response to organic substance	Orthology	biological process
multicellular organism development	Orthology	biological process
macromolecular complex binding	Orthology	molecular function
peptidase activity, acting on L-amino acid peptides	Orthology	molecular function
extracellular matrix organization	Orthology	biological process
cellular component organization	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
protein ubiquitination	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
macromolecular complex	Orthology	cellular component
endopeptidase activity	Orthology	molecular function
positive regulation of hydrolase activity	Orthology	biological process
regulation of molecular function	Orthology	biological process
immune system process	Orthology	biological process
protein transport	Orthology	biological process
cell-cell signaling	Orthology	biological process
neuron differentiation	Orthology	biological process
blood vessel morphogenesis	Orthology	biological process
cell projection assembly	Orthology	biological process
organelle organization	Orthology	biological process
anatomical structure development	Orthology	biological process
regulation of cell proliferation	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
G1/S transition of mitotic cell cycle	Hs	biological process
nucleotide binding	Hs	molecular function
activation of MAPKK activity	Hs	biological process
skeletal system development	Hs	biological process
angiogenesis	Hs	biological process
kidney development	Hs	biological process
epithelial to mesenchymal transition	Hs	biological process
positive regulation of endothelial cell proliferation	Hs	biological process
response to dietary excess	Hs	biological process
lens development in camera-type eye	Hs	biological process
ventricular trabecula myocardium morphogenesis	Hs	biological process
protein kinase activity	Hs	molecular function
protein serine/threonine kinase activity	Hs	molecular function
transmembrane receptor protein serine/threonine kinase activity	Hs	molecular function
signal transducer, downstream of receptor, with serine/threonine kinase activity	Hs	molecular function
transforming growth factor beta-activated receptor activity	Hs	molecular function
transforming growth factor beta receptor activity, type I	Hs	molecular function
signal transducer activity, downstream of receptor	Hs	molecular function
receptor binding	Hs	molecular function
type II transforming growth factor beta receptor binding	Hs	molecular function
protein binding	Hs	molecular function
ATP binding	Hs	molecular function
cell	Hs	cellular component
endosome	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
integral component of plasma membrane	Hs	cellular component
bicellular tight junction	Hs	cellular component
regulation of transcription, DNA-templated	Hs	biological process
protein phosphorylation	Hs	biological process
apoptotic process	Hs	biological process
cell cycle arrest	Hs	biological process
signal transduction	Hs	biological process
transmembrane receptor protein serine/threonine kinase signaling pathway	Hs	biological process
transforming growth factor beta receptor signaling pathway	Hs	biological process
central nervous system development	Hs	biological process
heart development	Hs	biological process
positive regulation of cell proliferation	Hs	biological process
germ cell migration	Hs	biological process
male gonad development	Hs	biological process
response to glucose	Hs	biological process
post-embryonic development	Hs	biological process
anterior/posterior pattern specification	Hs	biological process
regulation of signal transduction	Hs	biological process
cell surface	Hs	cellular component
regulation of gene expression	Hs	biological process
positive regulation of gene expression	Hs	biological process
negative regulation of gene expression	Hs	biological process
regulation of epithelial to mesenchymal transition	Hs	biological process
positive regulation of epithelial to mesenchymal transition	Hs	biological process
positive regulation of pathway-restricted SMAD protein phosphorylation	Hs	biological process
membrane	Hs	cellular component
integral component of membrane	Hs	cellular component
kinase activity	Hs	molecular function
phosphorylation	Hs	biological process
activin receptor activity, type I	Hs	molecular function
protein deubiquitination	Hs	biological process
transferase activity	Hs	molecular function
activin-activated receptor activity	Hs	molecular function
peptidyl-serine phosphorylation	Hs	biological process
peptidyl-threonine phosphorylation	Hs	biological process
growth factor binding	Hs	molecular function
lipid storage	Hs	biological process
signal transduction by protein phosphorylation	Hs	biological process
cell junction	Hs	cellular component
cell differentiation	Hs	biological process
collagen fibril organization	Hs	biological process
positive regulation of cell growth	Hs	biological process
negative regulation of cell growth	Hs	biological process
positive regulation of cell migration	Hs	biological process
negative regulation of transforming growth factor beta receptor signaling pathway	Hs	biological process
regulation of protein ubiquitination	Hs	biological process
ubiquitin protein ligase binding	Hs	molecular function
response to insulin	Hs	biological process
activin receptor signaling pathway	Hs	biological process
positive regulation of activin receptor signaling pathway	Hs	biological process
inhibin binding	Hs	molecular function
intracellular signal transduction	Hs	biological process
nodal signaling pathway	Hs	biological process
nodal binding	Hs	molecular function
regulation of growth	Hs	biological process
wound healing	Hs	biological process
positive regulation of apoptotic process	Hs	biological process
negative regulation of apoptotic process	Hs	biological process
intracellular membrane-bounded organelle	Hs	cellular component
receptor complex	Hs	cellular component
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Hs	biological process
regulation of protein binding	Hs	biological process
endothelial cell migration	Hs	biological process
membrane raft	Hs	cellular component
positive regulation of erythrocyte differentiation	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
SMAD binding	Hs	molecular function
development of primary female sexual characteristics	Hs	biological process
negative regulation of insulin secretion	Hs	biological process
protein autophosphorylation	Hs	biological process
metal ion binding	Hs	molecular function
activin receptor complex	Hs	cellular component
activin binding	Hs	molecular function
thymus development	Hs	biological process
neuron fate commitment	Hs	biological process
embryonic cranial skeleton morphogenesis	Hs	biological process
skeletal system morphogenesis	Hs	biological process
artery morphogenesis	Hs	biological process
cell motility	Hs	biological process
transforming growth factor beta binding	Hs	molecular function
positive regulation of filopodium assembly	Hs	biological process
positive regulation of stress fiber assembly	Hs	biological process
positive regulation of protein kinase B signaling	Hs	biological process
parathyroid gland development	Hs	biological process
palate development	Hs	biological process
pharyngeal system development	Hs	biological process
regulation of cardiac muscle cell proliferation	Hs	biological process
pathway-restricted SMAD protein phosphorylation	Hs	biological process
angiogenesis involved in coronary vascular morphogenesis	Hs	biological process
transforming growth factor beta receptor complex	Hs	cellular component
extracellular exosome	Hs	cellular component
I-SMAD binding	Hs	molecular function
cellular response to transforming growth factor beta stimulus	Hs	biological process
extrinsic apoptotic signaling pathway	Hs	biological process
positive regulation of trophoblast cell migration	Hs	biological process
positive regulation of apoptotic signaling pathway	Hs	biological process
negative regulation of extrinsic apoptotic signaling pathway	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
nucleotide binding	Hs	molecular function	452	7.59e-157
protein kinase activity	Hs	molecular function	452	7.59e-157
protein serine/threonine kinase activity	Hs	molecular function	452	7.59e-157
transmembrane receptor protein serine/threonine kinase activity	Hs	molecular function	452	7.59e-157
signal transducer, downstream of receptor, with serine/threonine kinase activity	Hs	molecular function	452	7.59e-157
transforming growth factor beta-activated receptor activity	Hs	molecular function	452	7.59e-157
transforming growth factor beta receptor activity, type I	Hs	molecular function	452	7.59e-157
signal transducer activity, downstream of receptor	Hs	molecular function	452	7.59e-157
receptor binding	Hs	molecular function	452	7.59e-157
type II transforming growth factor beta receptor binding	Hs	molecular function	452	7.59e-157
protein binding	Hs	molecular function	452	7.59e-157
ATP binding	Hs	molecular function	452	7.59e-157
cell	Hs	cellular component	452	7.59e-157
endosome	Hs	cellular component	452	7.59e-157
cytosol	Hs	cellular component	416	4.68e-142
plasma membrane	Hs	cellular component	452	7.59e-157
integral component of plasma membrane	Hs	cellular component	416	4.68e-142
bicellular tight junction	Hs	cellular component	452	7.59e-157
cell surface	Hs	cellular component	452	7.59e-157
membrane	Hs	cellular component	452	7.59e-157
integral component of membrane	Hs	cellular component	452	7.59e-157
kinase activity	Hs	molecular function	452	7.59e-157
activin receptor activity, type I	Hs	molecular function	430	3.24e-148
transferase activity	Hs	molecular function	452	7.59e-157
activin-activated receptor activity	Hs	molecular function	416	4.68e-142
growth factor binding	Hs	molecular function	452	7.59e-157
cell junction	Hs	cellular component	452	7.59e-157
ubiquitin protein ligase binding	Hs	molecular function	416	4.68e-142
inhibin binding	Hs	molecular function	416	4.68e-142
nodal binding	Hs	molecular function	430	3.24e-148
intracellular membrane-bounded organelle	Hs	cellular component	452	7.59e-157
receptor complex	Hs	cellular component	452	7.59e-157
membrane raft	Hs	cellular component	452	7.59e-157
SMAD binding	Hs	molecular function	452	7.59e-157
metal ion binding	Hs	molecular function	452	7.59e-157
activin receptor complex	Hs	cellular component	430	3.24e-148
activin binding	Hs	molecular function	416	4.68e-142
transforming growth factor beta binding	Hs	molecular function	452	7.59e-157
transforming growth factor beta receptor complex	Hs	cellular component	452	7.59e-157
extracellular exosome	Hs	cellular component	416	4.68e-142
I-SMAD binding	Hs	molecular function	452	7.59e-157

GO Term	Analysis	Type	e-value
protein kinase activity	Pfam	molecular function	1.7E-31
transmembrane receptor protein serine/threonine kinase activity	PANTHER	molecular function	8.1E-158
signal transducer, downstream of receptor, with serine/threonine kinase activity	PANTHER	molecular function	8.1E-158
ATP binding	PANTHER	molecular function	8.1E-158
protein phosphorylation	Pfam	biological process	1.7E-31
transmembrane receptor protein serine/threonine kinase signaling pathway	PANTHER	biological process	8.1E-158
membrane	PANTHER	cellular component	8.1E-158