IPR Term	Analysis	Definition
Ser_HO-MeTrfase	CDD	Serine hydroxymethyltransferase
PyrdxlP-dep_Trfase	SUPERFAMILY	Pyridoxal phosphate-dependent transferase
PyrdxlP-dep_Trfase_dom1	Gene3D	Pyridoxal phosphate-dependent transferase domain 1
Ser_HO-MeTrfase	Hamap	Serine hydroxymethyltransferase
Ser_HO-MeTrfase_PLP_BS	ProSitePatterns	Serine hydroxymethyltransferase, pyridoxal phosphate binding site
PyrdxlP-dep_Trfase_major	Gene3D	Pyridoxal phosphate-dependent transferase, major domain
Ser_HO-MeTrfase	PANTHER	Serine hydroxymethyltransferase
Ser_HO-MeTrfase	PIRSF	Serine hydroxymethyltransferase

GO Term	Annotation Origin	Type
chromatin binding	Blast	molecular function
catalytic activity	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
mitochondrial inner membrane	Blast	cellular component
mitochondrial matrix	Blast	cellular component
cytosol	Orthology	cellular component
microtubule cytoskeleton	Blast	cellular component
membrane	Blast	cellular component
transferase activity	Orthology	molecular function
identical protein binding	Orthology	molecular function
protein homodimerization activity	Orthology	molecular function
extracellular exosome	Orthology	cellular component
negative regulation of gene expression	Orthology	biological process
nucleic acid binding	Orthology	molecular function
peptidase activity, acting on L-amino acid peptides	Orthology	molecular function
phosphate-containing compound metabolic process	Orthology	biological process
cellular metabolic process	Orthology	biological process
cellular biosynthetic process	Orthology	biological process
nucleobase-containing compound metabolic process	Orthology	biological process
small molecule binding	Orthology	molecular function
anion binding	Orthology	molecular function
heterocyclic compound binding	Orthology	molecular function
organic cyclic compound binding	Orthology	molecular function
coenzyme binding	Orthology	molecular function
cellular aromatic compound metabolic process	Orthology	biological process
RNA binding	Orthology	molecular function
protein oligomerization	Orthology	biological process
protein homooligomerization	Orthology	biological process
cation binding	Orthology	molecular function
mitochondrial envelope	Blast	cellular component
intracellular organelle lumen	Blast	cellular component
metabolic process	Blast	biological process
intracellular non-membrane-bounded organelle	Blast	cellular component
nuclear part	Blast	cellular component
macromolecular complex	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
translation repressor activity, nucleic acid binding	Hs	molecular function
catalytic activity	Hs	molecular function
glycine hydroxymethyltransferase activity	Hs	molecular function
thiol-dependent ubiquitin-specific protease activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
cytosol	Hs	cellular component
dTMP biosynthetic process	Hs	biological process
glycine metabolic process	Hs	biological process
glycine biosynthetic process	Hs	biological process
L-serine metabolic process	Hs	biological process
one-carbon metabolic process	Hs	biological process
L-allo-threonine aldolase activity	Hs	molecular function
purine nucleobase biosynthetic process	Hs	biological process
protein deubiquitination	Hs	biological process
amino acid binding	Hs	molecular function
transferase activity	Hs	molecular function
negative regulation of translation	Hs	biological process
glycine biosynthetic process from serine	Hs	biological process
pyridoxal phosphate binding	Hs	molecular function
tetrahydrofolate interconversion	Hs	biological process
identical protein binding	Hs	molecular function
protein homodimerization activity	Hs	molecular function
carnitine biosynthetic process	Hs	biological process
tetrahydrofolate metabolic process	Hs	biological process
folic acid metabolic process	Hs	biological process
mRNA 5'-UTR binding	Hs	molecular function
protein tetramerization	Hs	biological process
protein homotetramerization	Hs	biological process
extracellular exosome	Hs	cellular component
serine binding	Hs	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
translation repressor activity, nucleic acid binding	Hs	molecular function	657	0.0
chromatin binding	Hs	molecular function	608	0.0
catalytic activity	Hs	molecular function	657	0.0
glycine hydroxymethyltransferase activity	Hs	molecular function	657	0.0
thiol-dependent ubiquitin-specific protease activity	Hs	molecular function	657	0.0
protein binding	Hs	molecular function	657	0.0
nucleus	Hs	cellular component	657	0.0
cytoplasm	Hs	cellular component	657	0.0
mitochondrion	Hs	cellular component	657	0.0
mitochondrial inner membrane	Hs	cellular component	608	0.0
mitochondrial intermembrane space	Hs	cellular component	608	0.0
mitochondrial matrix	Hs	cellular component	608	0.0
cytosol	Hs	cellular component	657	0.0
methyltransferase activity	Hs	molecular function	608	0.0
L-allo-threonine aldolase activity	Hs	molecular function	657	0.0
microtubule cytoskeleton	Hs	cellular component	608	0.0
membrane	Hs	cellular component	608	0.0
amino acid binding	Hs	molecular function	657	0.0
transferase activity	Hs	molecular function	657	0.0
pyridoxal phosphate binding	Hs	molecular function	657	0.0
mitochondrial nucleoid	Hs	cellular component	608	0.0
identical protein binding	Hs	molecular function	657	0.0
protein homodimerization activity	Hs	molecular function	657	0.0
mRNA 5'-UTR binding	Hs	molecular function	657	0.0
extracellular exosome	Hs	cellular component	657	0.0
BRISC complex	Hs	cellular component	608	0.0
serine binding	Hs	molecular function	657	0.0

GO Term	Analysis	Type	e-value
catalytic activity	Gene3D	molecular function	5.4E-211
glycine hydroxymethyltransferase activity	CDD	molecular function	0.0
glycine biosynthetic process from serine	CDD	biological process	0.0
pyridoxal phosphate binding	CDD	molecular function	0.0
tetrahydrofolate interconversion	CDD	biological process	0.0