IPR Term	Analysis	Definition
Fascin_metazoans	PIRSF	Fascin, metazoans
Actin-crosslinking	SUPERFAMILY	Actin-crosslinking
Fascin-domain	CDD	Fascin domain
Fascin	PANTHER	Fascin
Fascin-domain	Pfam	Fascin domain

GO Term	Annotation Origin	Type
RNA binding	Orthology	molecular function
actin binding	Orthology	molecular function
protein binding	Orthology	molecular function
cytoplasm	Orthology	cellular component
cytosol	Orthology	cellular component
cytoskeleton	Orthology	cellular component
visual perception	Orthology	biological process
cell proliferation	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
cell migration	Orthology	biological process
cytokine-mediated signaling pathway	Orthology	biological process
lamellipodium	Orthology	cellular component
cell junction	Orthology	cellular component
cell projection membrane	Orthology	cellular component
cell projection	Orthology	cellular component
myelin sheath	Orthology	cellular component
cell motility	Orthology	biological process
actin filament binding	Orthology	molecular function
extracellular exosome	Orthology	cellular component
cytoskeletal part	Orthology	cellular component
plasma membrane region	Orthology	cellular component
cell leading edge	Orthology	cellular component
macromolecular complex	Orthology	cellular component
organelle organization	Orthology	biological process
cellular process	Orthology	biological process
binding	Orthology	molecular function
cell projection assembly	Orthology	biological process
cell projection part	Orthology	cellular component
axon	Orthology	cellular component
neuron projection	Orthology	cellular component
cluster of actin-based cell projections	Orthology	cellular component
neuron development	Orthology	biological process
animal organ development	Orthology	biological process
cell adhesion molecule binding	Orthology	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
stress fiber	Hs	cellular component
ruffle	Hs	cellular component
podosome	Hs	cellular component
RNA binding	Hs	molecular function
actin binding	Hs	molecular function
protein binding	Hs	molecular function
cytoplasm	Hs	cellular component
cytosol	Hs	cellular component
cytoskeleton	Hs	cellular component
microvillus	Hs	cellular component
cell-cell junction	Hs	cellular component
actin filament organization	Hs	biological process
cell-cell junction assembly	Hs	biological process
establishment or maintenance of cell polarity	Hs	biological process
visual perception	Hs	biological process
drug binding	Hs	molecular function
cell proliferation	Hs	biological process
anatomical structure morphogenesis	Hs	biological process
positive regulation of lamellipodium assembly	Hs	biological process
actin cytoskeleton	Hs	cellular component
cell migration	Hs	biological process
cytokine-mediated signaling pathway	Hs	biological process
lamellipodium	Hs	cellular component
actin cytoskeleton organization	Hs	biological process
cell junction	Hs	cellular component
filopodium	Hs	cellular component
growth cone	Hs	cellular component
protein binding, bridging	Hs	molecular function
cell projection membrane	Hs	cellular component
filamentous actin	Hs	cellular component
stereocilium	Hs	cellular component
regulation of microvillus assembly	Hs	biological process
regulation of actin cytoskeleton organization	Hs	biological process
establishment of apical/basal cell polarity	Hs	biological process
eye photoreceptor cell development	Hs	biological process
cell projection	Hs	cellular component
myelin sheath	Hs	cellular component
microspike	Hs	cellular component
cadherin binding	Hs	molecular function
cell motility	Hs	biological process
actin filament binding	Hs	molecular function
actin filament bundle assembly	Hs	biological process
positive regulation of filopodium assembly	Hs	biological process
extracellular exosome	Hs	cellular component
invadopodium	Hs	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
stress fiber	Hs	cellular component	372	1.42e-124
ruffle	Hs	cellular component	372	1.42e-124
podosome	Hs	cellular component	372	1.42e-124
RNA binding	Hs	molecular function	372	1.42e-124
actin binding	Hs	molecular function	372	1.42e-124
protein binding	Hs	molecular function	372	1.42e-124
cytoplasm	Hs	cellular component	372	1.42e-124
cytosol	Hs	cellular component	372	1.42e-124
cytoskeleton	Hs	cellular component	372	1.42e-124
microvillus	Hs	cellular component	372	1.42e-124
cell-cell junction	Hs	cellular component	372	1.42e-124
drug binding	Hs	molecular function	372	1.42e-124
actin cytoskeleton	Hs	cellular component	372	1.42e-124
lamellipodium	Hs	cellular component	372	1.42e-124
cell junction	Hs	cellular component	372	1.42e-124
filopodium	Hs	cellular component	372	1.42e-124
growth cone	Hs	cellular component	372	1.42e-124
protein binding, bridging	Hs	molecular function	372	1.42e-124
cell projection membrane	Hs	cellular component	372	1.42e-124
filamentous actin	Hs	cellular component	372	1.42e-124
stereocilium	Hs	cellular component	296	8.48e-95
cell projection	Hs	cellular component	372	1.42e-124
myelin sheath	Hs	cellular component	372	1.42e-124
microspike	Hs	cellular component	372	1.42e-124
cadherin binding	Hs	molecular function	372	1.42e-124
actin filament binding	Hs	molecular function	372	1.42e-124
extracellular exosome	Hs	cellular component	372	1.42e-124
invadopodium	Hs	cellular component	372	1.42e-124

GO Term	Analysis	Type	e-value
actin filament organization	PANTHER	biological process	5.9E-142
protein binding, bridging	PIRSF	molecular function	1.0E-131
actin filament binding	PANTHER	molecular function	5.9E-142