Gene Card
Best human hits
CREBBP; EP300; UBR5
Species
Unique Gene ID
Phmamm.g00003536
Gene Model ID
Phmamm.CG.MTP2014.S116.g03536
Location
S116:145208..165317
Transcript Models and Sequences
AHC0AAA17YP20
Plate: Plate_17_P20
AHC0AAA45YO24
Plate: Plate_45_O24
n/a
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IPR Term | Analysis | Definition |
---|---|---|
KIX_dom | ProSiteProfiles | Coactivator CBP, KIX domain |
E3_UbLigase_EDD_UBA | CDD | E3 ubiquitin ligase EDD, ubiquitin-associated domain |
KIX_dom | Pfam | Coactivator CBP, KIX domain |
KIX_dom_sf | SUPERFAMILY | Coactivator CBP, KIX domain superfamily |
E3_UbLigase_EDD_UBA | Pfam | E3 ubiquitin ligase EDD, ubiquitin-associated domain |
GO Term | Annotation Origin | Type |
---|---|---|
protein polyubiquitination | Orthology | biological process |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | Blast | molecular function |
core promoter proximal region sequence-specific DNA binding | Blast | molecular function |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | Blast | molecular function |
DNA binding | Blast | molecular function |
chromatin binding | Blast | molecular function |
transcription factor activity, sequence-specific DNA binding | Blast | molecular function |
transcription cofactor activity | Blast | molecular function |
transcription coactivator activity | Blast | molecular function |
RNA binding | Orthology | molecular function |
ubiquitin-protein transferase activity | Orthology | molecular function |
signal transducer activity | Blast | molecular function |
protein binding | Orthology | molecular function |
nucleus | Orthology | cellular component |
nucleoplasm | Orthology | cellular component |
cytoplasm | Blast | cellular component |
cytosol | Orthology | cellular component |
DNA repair | Orthology | biological process |
regulation of transcription, DNA-templated | InterProScan | biological process |
cellular response to DNA damage stimulus | Orthology | biological process |
signal transduction | Orthology | biological process |
protein C-terminus binding | Blast | molecular function |
transcription factor binding | Blast | molecular function |
zinc ion binding | Orthology | molecular function |
cell proliferation | Orthology | biological process |
positive regulation of gene expression | Orthology | biological process |
membrane | Orthology | cellular component |
protein ubiquitination | Orthology | biological process |
nuclear body | Blast | cellular component |
transferase activity | Orthology | molecular function |
macromolecular complex | Orthology | cellular component |
metal ion binding | Orthology | molecular function |
perinuclear region of cytoplasm | Orthology | cellular component |
positive regulation of canonical Wnt signaling pathway | Orthology | biological process |
proteolysis | Orthology | biological process |
response to lipid | Orthology | biological process |
cellular response to organic substance | Orthology | biological process |
organelle organization | Orthology | biological process |
nucleoplasm part | Blast | cellular component |
intracellular non-membrane-bounded organelle | Blast | cellular component |
nuclear lumen | Blast | cellular component |
transcription regulatory region DNA binding | Blast | molecular function |
cellular protein modification process | Blast | biological process |
intracellular part | Blast | cellular component |
receptor binding | Blast | molecular function |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
protein polyubiquitination | Hs | biological process |
RNA binding | Hs | molecular function |
ubiquitin-protein transferase activity | Hs | molecular function |
protein binding | Hs | molecular function |
nucleus | Hs | cellular component |
nucleoplasm | Hs | cellular component |
cytosol | Hs | cellular component |
DNA repair | Hs | biological process |
ubiquitin-dependent protein catabolic process | Hs | biological process |
cellular response to DNA damage stimulus | Hs | biological process |
zinc ion binding | Hs | molecular function |
cell proliferation | Hs | biological process |
positive regulation of gene expression | Hs | biological process |
membrane | Hs | cellular component |
protein ubiquitination | Hs | biological process |
transferase activity | Hs | molecular function |
macromolecular complex | Hs | cellular component |
positive regulation of protein import into nucleus, translocation | Hs | biological process |
ubiquitin-ubiquitin ligase activity | Hs | molecular function |
ubiquitin binding | Hs | molecular function |
metal ion binding | Hs | molecular function |
perinuclear region of cytoplasm | Hs | cellular component |
progesterone receptor signaling pathway | Hs | biological process |
ubiquitin protein ligase activity | Hs | molecular function |
protein K48-linked ubiquitination | Hs | biological process |
positive regulation of canonical Wnt signaling pathway | Hs | biological process |
negative regulation of histone H2A K63-linked ubiquitination | Hs | biological process |
negative regulation of double-strand break repair | Hs | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
histone acetyltransferase complex | Hs | cellular component | 99.4 | 1.95e-20 |
nuclear chromatin | Hs | cellular component | 99.4 | 1.95e-20 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | Hs | molecular function | 91.3 | 6.18e-18 |
core promoter proximal region sequence-specific DNA binding | Hs | molecular function | 99.4 | 1.95e-20 |
core promoter binding | Hs | molecular function | 91.3 | 6.18e-18 |
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | Hs | molecular function | 99.4 | 1.95e-20 |
RNA polymerase II transcription factor binding | Hs | molecular function | 99.4 | 1.95e-20 |
RNA polymerase II activating transcription factor binding | Hs | molecular function | 99.4 | 1.95e-20 |
RNA polymerase II transcription coactivator activity | Hs | molecular function | 99.4 | 1.95e-20 |
transcriptional repressor activity, RNA polymerase II transcription factor binding | Hs | molecular function | 99.4 | 1.95e-20 |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | Hs | molecular function | 91.3 | 6.18e-18 |
p53 binding | Hs | molecular function | 99.4 | 1.95e-20 |
DNA binding | Hs | molecular function | 91.3 | 6.18e-18 |
chromatin binding | Hs | molecular function | 99.4 | 1.95e-20 |
damaged DNA binding | Hs | molecular function | 99.4 | 1.95e-20 |
transcription factor activity, sequence-specific DNA binding | Hs | molecular function | 99.4 | 1.95e-20 |
transcription cofactor activity | Hs | molecular function | 99.4 | 1.95e-20 |
transcription coactivator activity | Hs | molecular function | 99.4 | 1.95e-20 |
RNA binding | Hs | molecular function | 463 | 6.42e-132 |
histone acetyltransferase activity | Hs | molecular function | 99.4 | 1.95e-20 |
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor | Hs | molecular function | 91.3 | 6.18e-18 |
ubiquitin-protein transferase activity | Hs | molecular function | 463 | 6.42e-132 |
signal transducer activity | Hs | molecular function | 99.4 | 1.95e-20 |
protein binding | Hs | molecular function | 463 | 6.42e-132 |
nucleus | Hs | cellular component | 463 | 6.42e-132 |
nucleoplasm | Hs | cellular component | 463 | 6.42e-132 |
transcription factor complex | Hs | cellular component | 91.3 | 6.18e-18 |
chromosome | Hs | cellular component | 91.3 | 6.18e-18 |
cytoplasm | Hs | cellular component | 99.4 | 1.95e-20 |
cytosol | Hs | cellular component | 463 | 6.42e-132 |
beta-catenin binding | Hs | molecular function | 91.3 | 6.18e-18 |
protein C-terminus binding | Hs | molecular function | 91.3 | 6.18e-18 |
transcription factor binding | Hs | molecular function | 99.4 | 1.95e-20 |
zinc ion binding | Hs | molecular function | 463 | 6.42e-132 |
membrane | Hs | cellular component | 463 | 6.42e-132 |
acetyltransferase activity | Hs | molecular function | 99.4 | 1.95e-20 |
nuclear body | Hs | cellular component | 99.4 | 1.95e-20 |
transferase activity | Hs | molecular function | 463 | 6.42e-132 |
transferase activity, transferring acyl groups | Hs | molecular function | 99.4 | 1.95e-20 |
chromatin DNA binding | Hs | molecular function | 91.3 | 6.18e-18 |
macromolecular complex | Hs | cellular component | 463 | 6.42e-132 |
protein-DNA complex | Hs | cellular component | 91.3 | 6.18e-18 |
activating transcription factor binding | Hs | molecular function | 91.3 | 6.18e-18 |
peptide N-acetyltransferase activity | Hs | molecular function | 99.4 | 1.95e-20 |
ubiquitin-ubiquitin ligase activity | Hs | molecular function | 463 | 6.42e-132 |
nuclear hormone receptor binding | Hs | molecular function | 91.3 | 6.18e-18 |
ubiquitin binding | Hs | molecular function | 463 | 6.42e-132 |
MRF binding | Hs | molecular function | 99.4 | 1.95e-20 |
metal ion binding | Hs | molecular function | 463 | 6.42e-132 |
perinuclear region of cytoplasm | Hs | cellular component | 463 | 6.42e-132 |
androgen receptor binding | Hs | molecular function | 91.3 | 6.18e-18 |
ubiquitin protein ligase activity | Hs | molecular function | 463 | 6.42e-132 |
peptide-lysine-N-acetyltransferase activity | Hs | molecular function | 91.3 | 6.18e-18 |
protein propionyltransferase activity | Hs | molecular function | 91.3 | 6.18e-18 |
pre-mRNA intronic binding | Hs | molecular function | 91.3 | 6.18e-18 |
STAT family protein binding | Hs | molecular function | 91.3 | 6.18e-18 |
peptide butyryltransferase activity | Hs | molecular function | 91.3 | 6.18e-18 |
histone crotonyltransferase activity | Hs | molecular function | 91.3 | 6.18e-18 |
histone butyryltransferase activity | Hs | molecular function | 91.3 | 6.18e-18 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
transcription cofactor activity | SUPERFAMILY | molecular function | 2.22E-23 |
regulation of transcription, DNA-templated | SUPERFAMILY | biological process | 2.22E-23 |
ubiquitin binding | Pfam | molecular function | 5.3E-30 |