IPR Term	Analysis	Definition
FAD/NAD-linked_Rdtase_dimer_sf	Gene3D	FAD/NAD-linked reductase, dimerisation domain superfamily
FAD/NAD-linked_Rdtase_dimer_sf	SUPERFAMILY	FAD/NAD-linked reductase, dimerisation domain superfamily
Pyr_nucl-diS_OxRdtase_dimer	Pfam	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
FAD/NAD-bd_sf	SUPERFAMILY	FAD/NAD(P)-binding domain superfamily
FAD/NAD-binding_dom	Pfam	FAD/NAD(P)-binding domain
Glutaredoxin	ProSiteProfiles	Glutaredoxin
Thioredoxin/glutathione_Rdtase	TIGRFAM	Thioredoxin/glutathione reductase selenoprotein
Thioredoxin-like_sf	SUPERFAMILY	Thioredoxin-like superfamily
FAD/NAD-bd_sf	Gene3D	FAD/NAD(P)-binding domain superfamily
GLR_AS	ProSitePatterns	Glutaredoxin active site
Pyr_nuc-diS_OxRdtase	PIRSF	Pyridine nucleotide-disulphide oxidoreductase, class I
Glutaredoxin_euk/vir	TIGRFAM	Glutaredoxin, eukaryotic/virial
Pyr_OxRdtase_I_AS	ProSitePatterns	Pyridine nucleotide-disulphide oxidoreductase, class I, active site
Glutaredoxin	Pfam	Glutaredoxin

GO Term	Annotation Origin	Type
protein binding	Orthology	molecular function
cell	Orthology	cellular component
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
mitochondrial matrix	Blast	cellular component
endoplasmic reticulum	Orthology	cellular component
cytosol	Orthology	cellular component
signal transduction	Orthology	biological process
multicellular organism development	Orthology	biological process
spermatogenesis	Orthology	biological process
cell proliferation	Orthology	biological process
cell differentiation	Orthology	biological process
intracellular membrane-bounded organelle	Orthology	cellular component
flavin adenine dinucleotide binding	Orthology	molecular function
oxidation-reduction process	Orthology	biological process
extracellular exosome	Orthology	cellular component
response to oxidative stress	Orthology	biological process
nucleolus	Orthology	cellular component
anatomical structure formation involved in morphogenesis	Orthology	biological process
catalytic activity	Orthology	molecular function
cellular metabolic process	Orthology	biological process
organic substance metabolic process	Orthology	biological process
cellular response to stress	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
response to oxygen radical	Hs	biological process
fibrillar center	Hs	cellular component
mesoderm formation	Hs	biological process
thioredoxin-disulfide reductase activity	Hs	molecular function
protein binding	Hs	molecular function
cell	Hs	cellular component
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
endoplasmic reticulum	Hs	cellular component
cytosol	Hs	cellular component
signal transduction	Hs	biological process
multicellular organism development	Hs	biological process
spermatogenesis	Hs	biological process
gastrulation	Hs	biological process
cell proliferation	Hs	biological process
electron carrier activity	Hs	molecular function
protein disulfide oxidoreductase activity	Hs	molecular function
oxidoreductase activity	Hs	molecular function
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Hs	molecular function
regulation of lipid metabolic process	Hs	biological process
electron transport chain	Hs	biological process
cell differentiation	Hs	biological process
cellular response to oxidative stress	Hs	biological process
intracellular membrane-bounded organelle	Hs	cellular component
cell redox homeostasis	Hs	biological process
flavin adenine dinucleotide binding	Hs	molecular function
oxidation-reduction process	Hs	biological process
extracellular exosome	Hs	cellular component
methylselenol reductase activity	Hs	molecular function
methylseleninic acid reductase activity	Hs	molecular function
cellular oxidant detoxification	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
fibrillar center	Hs	cellular component	744	0.0
thioredoxin-disulfide reductase activity	Hs	molecular function	744	0.0
protein binding	Hs	molecular function	744	0.0
cell	Hs	cellular component	744	0.0
nucleus	Hs	cellular component	744	0.0
nucleoplasm	Hs	cellular component	744	0.0
cytoplasm	Hs	cellular component	744	0.0
mitochondrion	Hs	cellular component	744	0.0
mitochondrial matrix	Hs	cellular component	510	6.55e-177
endoplasmic reticulum	Hs	cellular component	739	0.0
cytosol	Hs	cellular component	744	0.0
electron carrier activity	Hs	molecular function	744	0.0
protein disulfide oxidoreductase activity	Hs	molecular function	744	0.0
oxidoreductase activity	Hs	molecular function	744	0.0
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	Hs	molecular function	744	0.0
intracellular membrane-bounded organelle	Hs	cellular component	739	0.0
flavin adenine dinucleotide binding	Hs	molecular function	744	0.0
extracellular exosome	Hs	cellular component	744	0.0
methylselenol reductase activity	Hs	molecular function	744	0.0
methylseleninic acid reductase activity	Hs	molecular function	744	0.0

GO Term	Analysis	Type	e-value
thioredoxin-disulfide reductase activity	TIGRFAM	molecular function	2.2E-225
electron carrier activity	PIRSF	molecular function	1.4E-66
protein disulfide oxidoreductase activity	Pfam	molecular function	8.7E-20
oxidoreductase activity	PIRSF	molecular function	1.4E-66
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	ProSitePatterns	molecular function
cell redox homeostasis	TIGRFAM	biological process	3.0E-27
flavin adenine dinucleotide binding	Gene3D	molecular function	2.5E-53
oxidation-reduction process	Pfam	biological process	2.3E-57