IPR Term	Analysis	Definition
SH3-like_dom_sf	SUPERFAMILY	SH3-like domain superfamily
Sorbin_SH3	PANTHER	Sorbin and SH3 domain-containing protein
SH3_domain	SMART	SH3 domain
SH3_domain	ProSiteProfiles	SH3 domain
SH3_domain	PRINTS	SH3 domain
SH3_domain	Pfam	SH3 domain

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
nucleic acid binding	Blast	molecular function
RNA binding	Blast	molecular function
actin binding	Blast	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Blast	cellular component
cytoplasm	Orthology	cellular component
centrosome	Blast	cellular component
cytosol	Orthology	cellular component
cytoskeleton	Orthology	cellular component
plasma membrane	Blast	cellular component
adherens junction	Blast	cellular component
cell-substrate adherens junction	Blast	cellular component
focal adhesion	Orthology	cellular component
cell adhesion	Orthology	biological process
cytoskeletal protein binding	Orthology	molecular function
transcription factor binding	Orthology	molecular function
positive regulation of signal transduction	Orthology	biological process
membrane	Blast	cellular component
apical plasma membrane	Blast	cellular component
lamellipodium	Blast	cellular component
cell junction	Orthology	cellular component
cell projection	Blast	cellular component
membrane raft	Blast	cellular component
perinuclear region of cytoplasm	Blast	cellular component
organelle organization	Orthology	biological process
structural molecule activity	Orthology	molecular function
intracellular signal transduction	Orthology	biological process
protein phosphorylation	Orthology	biological process
cytoskeletal part	Blast	cellular component
receptor binding	Blast	molecular function
macromolecular complex binding	Blast	molecular function
integral component of plasma membrane	Blast	cellular component
macromolecular complex	Blast	cellular component
nuclear lumen	Blast	cellular component
organelle part	Blast	cellular component
cytoplasmic part	Blast	cellular component
intracellular non-membrane-bounded organelle	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
structural constituent of cytoskeleton	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
cytoplasm	Hs	cellular component
cytosol	Hs	cellular component
cytoskeleton	Hs	cellular component
focal adhesion	Hs	cellular component
muscle contraction	Hs	biological process
actin filament organization	Hs	biological process
cell adhesion	Hs	biological process
transcription factor binding	Hs	molecular function
vinculin binding	Hs	molecular function
cell junction	Hs	cellular component
cell-substrate adhesion	Hs	biological process
positive regulation of MAPK cascade	Hs	biological process
positive regulation of cytoskeleton organization	Hs	biological process
positive regulation of stress fiber assembly	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
stress fiber	Hs	cellular component	122	3.21e-31
nucleic acid binding	Hs	molecular function	120	5.95e-31
RNA binding	Hs	molecular function	120	5.95e-31
actin binding	Hs	molecular function	122	3.21e-31
SH3/SH2 adaptor activity	Hs	molecular function	122	3.21e-31
insulin receptor binding	Hs	molecular function	122	3.21e-31
structural constituent of cytoskeleton	Hs	molecular function	120	5.95e-31
protein binding	Hs	molecular function	122	3.21e-31
nucleus	Hs	cellular component	122	3.21e-31
nucleoplasm	Hs	cellular component	120	5.95e-31
cytoplasm	Hs	cellular component	122	3.21e-31
centrosome	Hs	cellular component	122	3.21e-31
cytosol	Hs	cellular component	122	3.21e-31
cytoskeleton	Hs	cellular component	122	3.21e-31
plasma membrane	Hs	cellular component	122	3.21e-31
insulin receptor complex	Hs	cellular component	122	3.21e-31
adherens junction	Hs	cellular component	122	3.21e-31
cell-cell adherens junction	Hs	cellular component	122	3.21e-31
zonula adherens	Hs	cellular component	122	3.21e-31
cell-substrate adherens junction	Hs	cellular component	122	3.21e-31
focal adhesion	Hs	cellular component	122	3.21e-31
cytoskeletal protein binding	Hs	molecular function	122	3.21e-31
cytoskeletal adaptor activity	Hs	molecular function	120	5.95e-31
transcription factor binding	Hs	molecular function	116	1.60e-29
structural constituent of muscle	Hs	molecular function	120	5.95e-31
actin cytoskeleton	Hs	cellular component	120	5.95e-31
membrane	Hs	cellular component	122	3.21e-31
apical plasma membrane	Hs	cellular component	120	5.95e-31
nuclear matrix	Hs	cellular component	122	3.21e-31
vinculin binding	Hs	molecular function	116	1.60e-29
Z disc	Hs	cellular component	120	5.95e-31
lamellipodium	Hs	cellular component	120	5.95e-31
cell junction	Hs	cellular component	122	3.21e-31
cell projection	Hs	cellular component	120	5.95e-31
membrane raft	Hs	cellular component	122	3.21e-31
perinuclear region of cytoplasm	Hs	cellular component	120	5.95e-31

GO Term	Analysis	Type	e-value
protein binding	SUPERFAMILY	molecular function	5.38E-18
actin filament organization	PANTHER	biological process	7.5E-39