Gene Card
Best human hits
TH; TPH1; TPH2
Species
Unique Gene ID
Moocul.g00010278
Gene Model ID
Moocul.CG.ELv1_2.S106268.g10278
Location
S106268:1933..3334
Transcript Models and Sequences
n/a
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The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
ArAA_hydroxylase_Fe/CU_BS | ProSitePatterns | Aromatic amino acid hydroxylase, iron/copper binding site |
Aromatic-AA_hydroxylase_C | PRINTS | Aromatic amino acid hydroxylase, C-terminal |
Aromatic-AA_hydroxylase_C | ProSiteProfiles | Aromatic amino acid hydroxylase, C-terminal |
Aromatic-AA_hydroxylase_C | Pfam | Aromatic amino acid hydroxylase, C-terminal |
ArAA_hydroxylase | PANTHER | Aromatic amino acid hydroxylase |
Aro-AA_hydroxylase_C_sf | SUPERFAMILY | Aromatic amino acid monoxygenase, C-terminal domain superfamily |
ArAA_hydroxylase_sf | Gene3D | Aromatic amino acid hydroxylase superfamily |
GO Term | Annotation Origin | Type |
---|
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
response to hypoxia | Hs | biological process |
synaptic transmission, dopaminergic | Hs | biological process |
response to amphetamine | Hs | biological process |
heart morphogenesis | Hs | biological process |
monooxygenase activity | Hs | molecular function |
tyrosine 3-monooxygenase activity | Hs | molecular function |
iron ion binding | Hs | molecular function |
protein binding | Hs | molecular function |
nucleus | Hs | cellular component |
cytoplasm | Hs | cellular component |
mitochondrion | Hs | cellular component |
smooth endoplasmic reticulum | Hs | cellular component |
cytosol | Hs | cellular component |
dopamine biosynthetic process from tyrosine | Hs | biological process |
fatty acid metabolic process | Hs | biological process |
sphingolipid metabolic process | Hs | biological process |
heart development | Hs | biological process |
visual perception | Hs | biological process |
sensory perception of sound | Hs | biological process |
learning | Hs | biological process |
memory | Hs | biological process |
mating behavior | Hs | biological process |
locomotory behavior | Hs | biological process |
regulation of heart contraction | Hs | biological process |
synaptic vesicle | Hs | cellular component |
ferrous iron binding | Hs | molecular function |
ferric iron binding | Hs | molecular function |
aromatic amino acid family metabolic process | Hs | biological process |
response to light stimulus | Hs | biological process |
response to salt stress | Hs | biological process |
anatomical structure morphogenesis | Hs | biological process |
animal organ morphogenesis | Hs | biological process |
cytoplasmic side of plasma membrane | Hs | cellular component |
response to metal ion | Hs | biological process |
response to zinc ion | Hs | biological process |
multicellular organism aging | Hs | biological process |
response to organic cyclic compound | Hs | biological process |
response to activity | Hs | biological process |
aminergic neurotransmitter loading into synaptic vesicle | Hs | biological process |
oxidoreductase activity | Hs | molecular function |
amino acid binding | Hs | molecular function |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | Hs | molecular function |
oxygen binding | Hs | molecular function |
enzyme binding | Hs | molecular function |
protein domain specific binding | Hs | molecular function |
cerebral cortex development | Hs | biological process |
axon | Hs | cellular component |
dendrite | Hs | cellular component |
cytoplasmic vesicle membrane | Hs | cellular component |
cytoplasmic vesicle | Hs | cellular component |
response to nutrient levels | Hs | biological process |
response to estradiol | Hs | biological process |
response to lipopolysaccharide | Hs | biological process |
melanosome membrane | Hs | cellular component |
tetrahydrobiopterin binding | Hs | molecular function |
response to nicotine | Hs | biological process |
social behavior | Hs | biological process |
dopamine binding | Hs | molecular function |
neurotransmitter biosynthetic process | Hs | biological process |
dopamine biosynthetic process | Hs | biological process |
norepinephrine biosynthetic process | Hs | biological process |
catecholamine biosynthetic process | Hs | biological process |
eye photoreceptor cell development | Hs | biological process |
response to drug | Hs | biological process |
eating behavior | Hs | biological process |
neuron projection | Hs | cellular component |
neuronal cell body | Hs | cellular component |
terminal bouton | Hs | cellular component |
perikaryon | Hs | cellular component |
response to peptide hormone | Hs | biological process |
pigmentation | Hs | biological process |
response to ethanol | Hs | biological process |
metal ion binding | Hs | molecular function |
response to steroid hormone | Hs | biological process |
embryonic camera-type eye morphogenesis | Hs | biological process |
cognition | Hs | biological process |
response to electrical stimulus | Hs | biological process |
oxidation-reduction process | Hs | biological process |
response to growth factor | Hs | biological process |
cellular response to glucose stimulus | Hs | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
monooxygenase activity | Hs | molecular function | 350 | 1.66e-118 |
tryptophan 5-monooxygenase activity | Hs | molecular function | 317 | 3.51e-106 |
tyrosine 3-monooxygenase activity | Hs | molecular function | 350 | 1.66e-118 |
iron ion binding | Hs | molecular function | 350 | 1.66e-118 |
protein binding | Hs | molecular function | 350 | 1.66e-118 |
nucleus | Hs | cellular component | 350 | 1.66e-118 |
cytoplasm | Hs | cellular component | 350 | 1.66e-118 |
mitochondrion | Hs | cellular component | 350 | 1.66e-118 |
smooth endoplasmic reticulum | Hs | cellular component | 350 | 1.66e-118 |
cytosol | Hs | cellular component | 350 | 1.66e-118 |
synaptic vesicle | Hs | cellular component | 350 | 1.66e-118 |
ferrous iron binding | Hs | molecular function | 350 | 1.66e-118 |
ferric iron binding | Hs | molecular function | 350 | 1.66e-118 |
cytoplasmic side of plasma membrane | Hs | cellular component | 350 | 1.66e-118 |
oxidoreductase activity | Hs | molecular function | 350 | 1.66e-118 |
amino acid binding | Hs | molecular function | 350 | 1.66e-118 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | Hs | molecular function | 350 | 1.66e-118 |
oxygen binding | Hs | molecular function | 350 | 1.66e-118 |
enzyme binding | Hs | molecular function | 350 | 1.66e-118 |
protein domain specific binding | Hs | molecular function | 350 | 1.66e-118 |
axon | Hs | cellular component | 350 | 1.66e-118 |
dendrite | Hs | cellular component | 350 | 1.66e-118 |
cytoplasmic vesicle membrane | Hs | cellular component | 350 | 1.66e-118 |
cytoplasmic vesicle | Hs | cellular component | 350 | 1.66e-118 |
melanosome membrane | Hs | cellular component | 350 | 1.66e-118 |
tetrahydrobiopterin binding | Hs | molecular function | 350 | 1.66e-118 |
dopamine binding | Hs | molecular function | 350 | 1.66e-118 |
neuron projection | Hs | cellular component | 350 | 1.66e-118 |
neuronal cell body | Hs | cellular component | 350 | 1.66e-118 |
terminal bouton | Hs | cellular component | 350 | 1.66e-118 |
perikaryon | Hs | cellular component | 350 | 1.66e-118 |
metal ion binding | Hs | molecular function | 350 | 1.66e-118 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
monooxygenase activity | PANTHER | molecular function | 1.2E-137 |
iron ion binding | PANTHER | molecular function | 1.2E-137 |
aromatic amino acid family metabolic process | PANTHER | biological process | 1.2E-137 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | Pfam | molecular function | 1.2E-130 |
oxidation-reduction process | PANTHER | biological process | 1.2E-137 |