Gene Card
Best human hits
MTHFD1; MTHFD2; MTHFD2L
Species
Unique Gene ID
Moocci.g00015947
Gene Model ID
Moocci.CG.ELv1_2.S469602.g15947
Location
S469602:18615..34119
Transcript Models and Sequences
Moocci.CG.ELv1_2.S469602.g15947.01.t
Moocci.CG.ELv1_2.S469602.g15947.02.t
n/a
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The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.
Click here to see the tree inference method
InterPro
7 results
| IPR Term | Analysis | Definition |
|---|---|---|
| THF_DH/CycHdrlase_cat_dom | Pfam | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain |
| THF_DH/CycHdrlase | PRINTS | Tetrahydrofolate dehydrogenase/cyclohydrolase |
| THF_DH/CycHdrlase_NAD-bd_dom | Pfam | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain |
| THF_DH/CycHdrlase_CS | ProSitePatterns | Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site |
| NAD(P)-bd_dom_sf | SUPERFAMILY | NAD(P)-binding domain superfamily |
| THF_DH/CycHdrlase | Hamap | Tetrahydrofolate dehydrogenase/cyclohydrolase |
| THF_DH/CycHdrlase | PANTHER | Tetrahydrofolate dehydrogenase/cyclohydrolase |
| GO Term | Annotation Origin | Type |
|---|
GO (Orthology)
22 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
|---|---|---|
| magnesium ion binding | Hs | molecular function |
| catalytic activity | Hs | molecular function |
| methenyltetrahydrofolate cyclohydrolase activity | Hs | molecular function |
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | Hs | molecular function |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | Hs | molecular function |
| extracellular space | Hs | cellular component |
| mitochondrion | Hs | cellular component |
| mitochondrial inner membrane | Hs | cellular component |
| mitochondrial matrix | Hs | cellular component |
| purine nucleotide biosynthetic process | Hs | biological process |
| one-carbon metabolic process | Hs | biological process |
| metabolic process | Hs | biological process |
| cellular amino acid biosynthetic process | Hs | biological process |
| methionine biosynthetic process | Hs | biological process |
| membrane | Hs | cellular component |
| oxidoreductase activity | Hs | molecular function |
| hydrolase activity | Hs | molecular function |
| tetrahydrofolate interconversion | Hs | biological process |
| phosphate ion binding | Hs | molecular function |
| tetrahydrofolate metabolic process | Hs | biological process |
| folic acid metabolic process | Hs | biological process |
| oxidation-reduction process | Hs | biological process |
GO (Blast)
22 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
|---|---|---|---|---|
| nucleotide binding | Hs | molecular function | 201 | 5.88e-58 |
| magnesium ion binding | Hs | molecular function | 410 | 2.90e-144 |
| catalytic activity | Hs | molecular function | 416 | 1.53e-146 |
| formate-tetrahydrofolate ligase activity | Hs | molecular function | 201 | 5.88e-58 |
| methenyltetrahydrofolate cyclohydrolase activity | Hs | molecular function | 416 | 1.53e-146 |
| methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity | Hs | molecular function | 201 | 5.88e-58 |
| methylenetetrahydrofolate dehydrogenase (NAD+) activity | Hs | molecular function | 416 | 1.53e-146 |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | Hs | molecular function | 416 | 1.53e-146 |
| protein binding | Hs | molecular function | 201 | 5.88e-58 |
| ATP binding | Hs | molecular function | 201 | 5.88e-58 |
| extracellular space | Hs | cellular component | 410 | 2.90e-144 |
| cytoplasm | Hs | cellular component | 201 | 5.88e-58 |
| mitochondrion | Hs | cellular component | 416 | 1.53e-146 |
| mitochondrial inner membrane | Hs | cellular component | 416 | 1.53e-146 |
| mitochondrial matrix | Hs | cellular component | 416 | 1.53e-146 |
| cytosol | Hs | cellular component | 201 | 5.88e-58 |
| membrane | Hs | cellular component | 416 | 1.53e-146 |
| oxidoreductase activity | Hs | molecular function | 416 | 1.53e-146 |
| hydrolase activity | Hs | molecular function | 416 | 1.53e-146 |
| ligase activity | Hs | molecular function | 201 | 5.88e-58 |
| phosphate ion binding | Hs | molecular function | 410 | 2.90e-144 |
| extracellular exosome | Hs | cellular component | 201 | 5.88e-58 |
GO (InterProScan)
3 results
| GO Term | Analysis | Type | e-value |
|---|---|---|---|
| catalytic activity | ProSitePatterns | molecular function | |
| methylenetetrahydrofolate dehydrogenase (NADP+) activity | PANTHER | molecular function | 5.1E-149 |
| oxidation-reduction process | PANTHER | biological process | 5.1E-149 |
