Gene Card
Best human hits
IRAK1; IRAK2; IRAK4
Unique Gene ID
Cirobu.g00008824
Gene Model ID
KH2012:KH.C8.21
Location
KhC8:4622026..4626991
Transcript Models and Sequences
cien123987
Plate: VES89_L15
cien192931
Plate: VES100_N04
citb040d18
Plate: R1CiGC32h18
n/a
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
Ser/Thr_kinase_AS | ProSitePatterns | Serine/threonine-protein kinase, active site |
Ser-Thr/Tyr_kinase_cat_dom | Pfam | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Kinase-like_dom_sf | SUPERFAMILY | Protein kinase-like domain superfamily |
DEATH-like_dom_sf | SUPERFAMILY | Death-like domain superfamily |
Prot_kinase_dom | SMART | Protein kinase domain |
Protein_kinase_ATP_BS | ProSitePatterns | Protein kinase, ATP binding site |
Prot_kinase_dom | ProSiteProfiles | Protein kinase domain |
GO Term | Annotation Origin | Type |
---|---|---|
nucleotide binding | Orthology | molecular function |
magnesium ion binding | Orthology | molecular function |
immune system process | Orthology | biological process |
protein kinase activity | Orthology | molecular function |
protein serine/threonine kinase activity | Orthology | molecular function |
protein binding | Orthology | molecular function |
ATP binding | Orthology | molecular function |
extracellular space | Orthology | cellular component |
intracellular | Orthology | cellular component |
nucleus | Orthology | cellular component |
cytoplasm | Orthology | cellular component |
cytosol | Orthology | cellular component |
plasma membrane | Orthology | cellular component |
protein phosphorylation | Orthology | biological process |
signal transduction | Orthology | biological process |
membrane | Blast | cellular component |
kinase activity | Orthology | molecular function |
phosphorylation | Orthology | biological process |
transferase activity | Orthology | molecular function |
cytokine-mediated signaling pathway | Orthology | biological process |
intracellular signal transduction | Orthology | biological process |
protein homodimerization activity | Blast | molecular function |
innate immune response | Orthology | biological process |
protein heterodimerization activity | Blast | molecular function |
receptor binding | Orthology | molecular function |
cellular response to stress | Orthology | biological process |
intracellular organelle part | Orthology | cellular component |
whole membrane | Orthology | cellular component |
endosome | Orthology | cellular component |
bounding membrane of organelle | Orthology | cellular component |
transcription factor activity, sequence-specific DNA binding | Orthology | molecular function |
positive regulation of signal transduction | Orthology | biological process |
cell migration | Orthology | biological process |
enzyme regulator activity | Blast | molecular function |
intracellular non-membrane-bounded organelle | Blast | cellular component |
integral component of plasma membrane | Blast | cellular component |
macromolecular complex | Blast | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
nucleotide binding | Hs | molecular function |
magnesium ion binding | Hs | molecular function |
cytokine production | Hs | biological process |
toll-like receptor signaling pathway | Hs | biological process |
immune system process | Hs | biological process |
neutrophil mediated immunity | Hs | biological process |
MyD88-dependent toll-like receptor signaling pathway | Hs | biological process |
protein kinase activity | Hs | molecular function |
protein serine/threonine kinase activity | Hs | molecular function |
interleukin-1 receptor binding | Hs | molecular function |
protein binding | Hs | molecular function |
ATP binding | Hs | molecular function |
extracellular space | Hs | cellular component |
intracellular | Hs | cellular component |
nucleus | Hs | cellular component |
cytoplasm | Hs | cellular component |
cytosol | Hs | cellular component |
plasma membrane | Hs | cellular component |
protein phosphorylation | Hs | biological process |
signal transduction | Hs | biological process |
JNK cascade | Hs | biological process |
endosome membrane | Hs | cellular component |
kinase activity | Hs | molecular function |
phosphorylation | Hs | biological process |
transferase activity | Hs | molecular function |
cytokine-mediated signaling pathway | Hs | biological process |
toll-like receptor 9 signaling pathway | Hs | biological process |
positive regulation of I-kappaB kinase/NF-kappaB signaling | Hs | biological process |
innate immune response | Hs | biological process |
positive regulation of NF-kappaB transcription factor activity | Hs | biological process |
interleukin-1-mediated signaling pathway | Hs | biological process |
neutrophil migration | Hs | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
nucleotide binding | Hs | molecular function | 205 | 1.54e-59 |
magnesium ion binding | Hs | molecular function | 205 | 1.54e-59 |
protein kinase activity | Hs | molecular function | 205 | 1.54e-59 |
protein serine/threonine kinase activity | Hs | molecular function | 205 | 1.54e-59 |
NF-kappaB-inducing kinase activity | Hs | molecular function | 137 | 5.88e-34 |
interleukin-1 receptor binding | Hs | molecular function | 205 | 1.54e-59 |
protein binding | Hs | molecular function | 205 | 1.54e-59 |
ATP binding | Hs | molecular function | 205 | 1.54e-59 |
extracellular space | Hs | cellular component | 205 | 1.54e-59 |
intracellular | Hs | cellular component | 205 | 1.54e-59 |
nucleus | Hs | cellular component | 205 | 1.54e-59 |
cytoplasm | Hs | cellular component | 205 | 1.54e-59 |
lipid droplet | Hs | cellular component | 137 | 5.88e-34 |
cytosol | Hs | cellular component | 205 | 1.54e-59 |
plasma membrane | Hs | cellular component | 205 | 1.54e-59 |
endosome membrane | Hs | cellular component | 205 | 1.54e-59 |
membrane | Hs | cellular component | 137 | 5.88e-34 |
kinase activity | Hs | molecular function | 205 | 1.54e-59 |
transferase activity | Hs | molecular function | 205 | 1.54e-59 |
heat shock protein binding | Hs | molecular function | 137 | 5.88e-34 |
protein homodimerization activity | Hs | molecular function | 137 | 5.88e-34 |
interleukin-1 receptor complex | Hs | cellular component | 137 | 5.88e-34 |
protein heterodimerization activity | Hs | molecular function | 137 | 5.88e-34 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
protein kinase activity | Pfam | molecular function | 1.9E-46 |
ATP binding | SMART | molecular function | 6.6E-42 |
protein phosphorylation | Pfam | biological process | 1.9E-46 |