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Gene Card

Best human hits

MYD88; TLR3; TLR4

Species

H.roretzi

Unique Gene ID

Harore.g00014985

Gene Model ID

Harore.CG.MTP2014.S24.g14985

Location

S24:261887..265732

Transcript Models and Sequences

  Harore.CG.MTP2014.S24.g14985.01.t

External Database Gene Card

External database links

No result

Collections
WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

8 results

IPR Term Analysis Definition
TIR_dom SMART Toll/interleukin-1 receptor homology (TIR) domain
TIR_dom ProSiteProfiles Toll/interleukin-1 receptor homology (TIR) domain
Death_domain ProSiteProfiles Death domain
Death_domain Pfam Death domain
TIR_dom Pfam Toll/interleukin-1 receptor homology (TIR) domain
Toll_tir_struct_dom_sf Gene3D Toll/interleukin-1 receptor homology (TIR) domain superfamily
DEATH-like_dom_sf SUPERFAMILY Death-like domain superfamily
Toll_tir_struct_dom_sf SUPERFAMILY Toll/interleukin-1 receptor homology (TIR) domain superfamily

GOSlim

57 results

GO Term Annotation Origin Type
Golgi membrane Blast cellular component
immune system process Orthology biological process
RNA binding Blast molecular function
transmembrane signaling receptor activity Blast molecular function
receptor binding Orthology molecular function
protein binding Orthology molecular function
intracellular Blast cellular component
nucleus Orthology cellular component
cytoplasm Orthology cellular component
lysosomal membrane Blast cellular component
endosome Orthology cellular component
early endosome Blast cellular component
endoplasmic reticulum Blast cellular component
endoplasmic reticulum membrane Blast cellular component
cytosol Orthology cellular component
plasma membrane Orthology cellular component
integral component of plasma membrane Blast cellular component
apoptotic process Orthology biological process
defense response Orthology biological process
immune response Orthology biological process
signal transduction Orthology biological process
cell surface receptor signaling pathway Orthology biological process
response to bacterium Orthology biological process
cell surface Blast cellular component
regulation of gene expression Orthology biological process
positive regulation of gene expression Orthology biological process
membrane Blast cellular component
integral component of membrane Blast cellular component
cytokine-mediated signaling pathway Orthology biological process
intrinsic component of plasma membrane Blast cellular component
response to lipopolysaccharide Orthology biological process
regulation of cell proliferation Orthology biological process
identical protein binding Orthology molecular function
negative regulation of apoptotic process Orthology biological process
innate immune response Orthology biological process
protein heterodimerization activity Blast molecular function
perinuclear region of cytoplasm Blast cellular component
cellular response to stress Orthology biological process
intracellular signal transduction Orthology biological process
protein phosphorylation Orthology biological process
intracellular organelle part Orthology cellular component
whole membrane Orthology cellular component
bounding membrane of organelle Orthology cellular component
organelle Orthology cellular component
postsynapse Orthology cellular component
neuron part Orthology cellular component
cellular response to organic substance Orthology biological process
response to molecule of bacterial origin Orthology biological process
transcription factor activity, sequence-specific DNA binding Orthology molecular function
positive regulation of signal transduction Orthology biological process
mRNA catabolic process Orthology biological process
cell development Orthology biological process
cell migration Orthology biological process
carbohydrate derivative binding Blast molecular function
signaling receptor activity Blast molecular function
plasma membrane part Blast cellular component
macromolecular complex Blast cellular component

GO (Orthology)

48 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
toll-like receptor signaling pathway Hs biological process
immune system process Hs biological process
MyD88-dependent toll-like receptor signaling pathway Hs biological process
receptor binding Hs molecular function
Toll binding Hs molecular function
death receptor binding Hs molecular function
interleukin-1 receptor binding Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
cytoplasm Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
apoptotic process Hs biological process
inflammatory response Hs biological process
signal transduction Hs biological process
cell surface receptor signaling pathway Hs biological process
JNK cascade Hs biological process
Toll signaling pathway Hs biological process
response to virus Hs biological process
endosome membrane Hs cellular component
regulation of gene expression Hs biological process
positive regulation of gene expression Hs biological process
postsynaptic density Hs cellular component
immunoglobulin mediated immune response Hs biological process
cytokine-mediated signaling pathway Hs biological process
lipopolysaccharide-mediated signaling pathway Hs biological process
positive regulation of type I interferon production Hs biological process
response to peptidoglycan Hs biological process
response to lipopolysaccharide Hs biological process
toll-like receptor 9 signaling pathway Hs biological process
Toll-like receptor binding Hs molecular function
regulation of cell proliferation Hs biological process
identical protein binding Hs molecular function
negative regulation of apoptotic process Hs biological process
positive regulation of I-kappaB kinase/NF-kappaB signaling Hs biological process
protein self-association Hs molecular function
negative regulation of growth of symbiont in host Hs biological process
innate immune response Hs biological process
positive regulation of JNK cascade Hs biological process
regulation of inflammatory response Hs biological process
defense response to Gram-positive bacterium Hs biological process
positive regulation of NF-kappaB transcription factor activity Hs biological process
interleukin-1-mediated signaling pathway Hs biological process
3'-UTR-mediated mRNA stabilization Hs biological process
TIR domain binding Hs molecular function
cellular response to mechanical stimulus Hs biological process
establishment of endothelial intestinal barrier Hs biological process
regulation of neutrophil migration Hs biological process

GO (Blast)

39 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
Golgi membrane Hs cellular component 41.2 0.002
lipopolysaccharide binding Hs molecular function 46.6 2.78e-05
lipopolysaccharide receptor activity Hs molecular function 46.6 2.78e-05
RNA binding Hs molecular function 41.2 0.002
double-stranded RNA binding Hs molecular function 41.2 0.002
receptor activity Hs molecular function 46.6 2.78e-05
transmembrane signaling receptor activity Hs molecular function 46.6 2.78e-05
receptor binding Hs molecular function 104 8.06e-25
Toll binding Hs molecular function 104 8.06e-25
death receptor binding Hs molecular function 104 8.06e-25
interleukin-1 receptor binding Hs molecular function 104 8.06e-25
protein binding Hs molecular function 104 8.06e-25
intracellular Hs cellular component 46.6 2.78e-05
nucleus Hs cellular component 104 8.06e-25
cytoplasm Hs cellular component 104 8.06e-25
lysosomal membrane Hs cellular component 41.2 0.002
endosome Hs cellular component 46.6 2.78e-05
early endosome Hs cellular component 46.6 2.78e-05
endoplasmic reticulum Hs cellular component 41.2 0.002
endoplasmic reticulum membrane Hs cellular component 41.2 0.002
cytosol Hs cellular component 104 8.06e-25
plasma membrane Hs cellular component 104 8.06e-25
integral component of plasma membrane Hs cellular component 46.6 2.78e-05
external side of plasma membrane Hs cellular component 46.6 2.78e-05
cell surface Hs cellular component 46.6 2.78e-05
endosome membrane Hs cellular component 104 8.06e-25
postsynaptic density Hs cellular component 104 8.06e-25
membrane Hs cellular component 46.6 2.78e-05
integral component of membrane Hs cellular component 46.6 2.78e-05
intrinsic component of plasma membrane Hs cellular component 46.6 2.78e-05
Toll-like receptor binding Hs molecular function 104 8.06e-25
endolysosome membrane Hs cellular component 41.2 0.002
identical protein binding Hs molecular function 104 8.06e-25
receptor complex Hs cellular component 46.6 2.78e-05
protein self-association Hs molecular function 104 8.06e-25
lipopolysaccharide receptor complex Hs cellular component 46.6 2.78e-05
protein heterodimerization activity Hs molecular function 46.6 2.78e-05
perinuclear region of cytoplasm Hs cellular component 46.6 2.78e-05
TIR domain binding Hs molecular function 104 8.06e-25

GO (InterProScan)

2 results

GO Term Analysis Type e-value
protein binding Pfam molecular function 2.5E-7
signal transduction Pfam biological process 2.5E-7

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