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Gene Card

Best human hits

MTHFD1; MTHFD2; MTHFD2L

Species

H.roretzi

Unique Gene ID

Harore.g00008010

Gene Model ID

Harore.CG.MTP2014.S116.g08010

Location

S116:0..4561

Transcript Models and Sequences

  Harore.CG.MTP2014.S116.g08010.01.t

External Database Gene Card

External database links

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Genomicus Synteny Browser

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Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

7 results

IPR Term Analysis Definition
THF_DH/CycHdrlase_cat_dom Pfam Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
NAD(P)-bd_dom_sf SUPERFAMILY NAD(P)-binding domain superfamily
THF_DH/CycHdrlase_CS ProSitePatterns Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
THF_DH/CycHdrlase PANTHER Tetrahydrofolate dehydrogenase/cyclohydrolase
THF_DH/CycHdrlase Hamap Tetrahydrofolate dehydrogenase/cyclohydrolase
THF_DH/CycHdrlase_NAD-bd_dom Pfam Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
THF_DH/CycHdrlase PRINTS Tetrahydrofolate dehydrogenase/cyclohydrolase

GOSlim

22 results

GO Term Annotation Origin Type
nucleotide binding Blast molecular function
magnesium ion binding Orthology molecular function
catalytic activity Orthology molecular function
protein binding Blast molecular function
ATP binding Blast molecular function
extracellular space Orthology cellular component
cytoplasm Blast cellular component
mitochondrion Orthology cellular component
mitochondrial inner membrane Orthology cellular component
mitochondrial matrix Orthology cellular component
cytosol Blast cellular component
metabolic process Orthology biological process
membrane Orthology cellular component
hydrolase activity Orthology molecular function
ligase activity Blast molecular function
oxidation-reduction process Orthology biological process
extracellular exosome Blast cellular component
phosphate-containing compound metabolic process Orthology biological process
cellular metabolic process Orthology biological process
cellular biosynthetic process Orthology biological process
cellular aromatic compound metabolic process Orthology biological process
anion binding Orthology molecular function

GO (Orthology)

22 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
magnesium ion binding Hs molecular function
catalytic activity Hs molecular function
methenyltetrahydrofolate cyclohydrolase activity Hs molecular function
methylenetetrahydrofolate dehydrogenase (NAD+) activity Hs molecular function
methylenetetrahydrofolate dehydrogenase (NADP+) activity Hs molecular function
extracellular space Hs cellular component
mitochondrion Hs cellular component
mitochondrial inner membrane Hs cellular component
mitochondrial matrix Hs cellular component
purine nucleotide biosynthetic process Hs biological process
one-carbon metabolic process Hs biological process
metabolic process Hs biological process
cellular amino acid biosynthetic process Hs biological process
methionine biosynthetic process Hs biological process
membrane Hs cellular component
oxidoreductase activity Hs molecular function
hydrolase activity Hs molecular function
tetrahydrofolate interconversion Hs biological process
phosphate ion binding Hs molecular function
tetrahydrofolate metabolic process Hs biological process
folic acid metabolic process Hs biological process
oxidation-reduction process Hs biological process

GO (Blast)

22 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nucleotide binding Hs molecular function 197 4.74e-56
magnesium ion binding Hs molecular function 411 4.37e-144
catalytic activity Hs molecular function 411 4.37e-144
formate-tetrahydrofolate ligase activity Hs molecular function 197 4.74e-56
methenyltetrahydrofolate cyclohydrolase activity Hs molecular function 411 4.37e-144
methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity Hs molecular function 197 4.74e-56
methylenetetrahydrofolate dehydrogenase (NAD+) activity Hs molecular function 411 4.37e-144
methylenetetrahydrofolate dehydrogenase (NADP+) activity Hs molecular function 411 4.37e-144
protein binding Hs molecular function 197 4.74e-56
ATP binding Hs molecular function 197 4.74e-56
extracellular space Hs cellular component 411 4.37e-144
cytoplasm Hs cellular component 197 4.74e-56
mitochondrion Hs cellular component 411 4.37e-144
mitochondrial inner membrane Hs cellular component 410 1.10e-143
mitochondrial matrix Hs cellular component 411 4.37e-144
cytosol Hs cellular component 197 4.74e-56
membrane Hs cellular component 410 1.10e-143
oxidoreductase activity Hs molecular function 411 4.37e-144
hydrolase activity Hs molecular function 411 4.37e-144
ligase activity Hs molecular function 197 4.74e-56
phosphate ion binding Hs molecular function 411 4.37e-144
extracellular exosome Hs cellular component 197 4.74e-56

GO (InterProScan)

3 results

GO Term Analysis Type e-value
catalytic activity ProSitePatterns molecular function
methylenetetrahydrofolate dehydrogenase (NADP+) activity PANTHER molecular function 4.3E-140
oxidation-reduction process PANTHER biological process 4.3E-140

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