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Gene Card

Best human hits

DNMT1; KMT2A; KMT2B

Species

C.savignyi

Unique Gene ID

Cisavi.g00003818

Gene Model ID

Cisavi.CG.ENS81.R19.352221-359701

Location

R19:352220..359701

Transcript Models and Sequences

  Cisavi.CG.ENS81.R19.352221-359701.10295.t
Cisavi.CG.ENS81.R19.352221-359701.10296.t

External Database Gene Card

External database links

No result

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WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

14 results

IPR Term Analysis Definition
C5_DNA_meth_AS ProSitePatterns DNA methylase, C-5 cytosine-specific, active site
C5_meth_CS ProSitePatterns DNA methylase, C-5 cytosine-specific, conserved site
Znf_CXXC Pfam Zinc finger, CXXC-type
Cytosine_MeTrfase1_RFD Pfam DNA (cytosine-5)-methyltransferase 1, replication foci domain
BAH_dom SMART Bromo adjacent homology (BAH) domain
Znf_CXXC ProSiteProfiles Zinc finger, CXXC-type
BAH_dom ProSiteProfiles Bromo adjacent homology (BAH) domain
BAH_dom Pfam Bromo adjacent homology (BAH) domain
DNMT1-like PIRSF DNA (cytosine-5)-methyltransferase 1-like
C5_MeTfrase Pfam C-5 cytosine methyltransferase
C5_MeTfrase TIGRFAM C-5 cytosine methyltransferase
C5_MeTfrase PRINTS C-5 cytosine methyltransferase
C5_MeTfrase ProSiteProfiles C-5 cytosine methyltransferase
SAM-dependent_MTases SUPERFAMILY S-adenosyl-L-methionine-dependent methyltransferase

GOSlim

No result

GO Term Annotation Origin Type

GO (Orthology)

37 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
heterochromatin Hs cellular component
DNA binding Hs molecular function
chromatin binding Hs molecular function
RNA binding Hs molecular function
DNA (cytosine-5-)-methyltransferase activity Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
replication fork Hs cellular component
pericentric heterochromatin Hs cellular component
DNA methylation Hs biological process
chromatin organization Hs biological process
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
Ras protein signal transduction Hs biological process
methyltransferase activity Hs molecular function
zinc ion binding Hs molecular function
methyl-CpG binding Hs molecular function
DNA-methyltransferase activity Hs molecular function
maintenance of DNA methylation Hs biological process
regulation of gene expression Hs biological process
positive regulation of gene expression Hs biological process
gene silencing Hs biological process
transferase activity Hs molecular function
methylation Hs biological process
DNA methylation on cytosine Hs biological process
regulation of cell proliferation Hs biological process
DNA methylation involved in embryo development Hs biological process
negative regulation of gene expression, epigenetic Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
metal ion binding Hs molecular function
positive regulation of histone H3-K4 methylation Hs biological process
cellular response to amino acid stimulus Hs biological process
C-5 methylation of cytosine Hs biological process
positive regulation of methylation-dependent chromatin silencing Hs biological process
promoter-specific chromatin binding Hs molecular function

GO (Blast)

31 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
heterochromatin Hs cellular component 1394 0.0
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function 57.4 6.38e-08
core promoter sequence-specific DNA binding Hs molecular function 57.4 6.38e-08
DNA binding Hs molecular function 1394 0.0
AT DNA binding Hs molecular function 57.4 6.38e-08
chromatin binding Hs molecular function 1394 0.0
transcription factor activity, sequence-specific DNA binding Hs molecular function 57.4 6.38e-08
RNA binding Hs molecular function 1394 0.0
DNA (cytosine-5-)-methyltransferase activity Hs molecular function 1394 0.0
protein binding Hs molecular function 1394 0.0
nucleus Hs cellular component 1394 0.0
nucleoplasm Hs cellular component 1394 0.0
replication fork Hs cellular component 1394 0.0
pericentric heterochromatin Hs cellular component 1394 0.0
cytosol Hs cellular component 57.4 6.38e-08
methyltransferase activity Hs molecular function 1394 0.0
zinc ion binding Hs molecular function 1394 0.0
methyl-CpG binding Hs molecular function 1394 0.0
DNA-methyltransferase activity Hs molecular function 1394 0.0
transferase activity Hs molecular function 1394 0.0
histone-lysine N-methyltransferase activity Hs molecular function 57.4 6.38e-08
histone methyltransferase complex Hs cellular component 57.4 6.38e-08
histone methyltransferase activity (H3-K4 specific) Hs molecular function 57.4 6.38e-08
identical protein binding Hs molecular function 57.4 6.38e-08
protein homodimerization activity Hs molecular function 57.4 6.38e-08
transcription regulatory region DNA binding Hs molecular function 57.4 6.38e-08
unmethylated CpG binding Hs molecular function 57.4 6.38e-08
metal ion binding Hs molecular function 1394 0.0
lysine-acetylated histone binding Hs molecular function 57.4 6.38e-08
MLL1 complex Hs cellular component 57.4 6.38e-08
promoter-specific chromatin binding Hs molecular function 1394 0.0

GO (InterProScan)

7 results

GO Term Analysis Type e-value
DNA binding Pfam molecular function 1.1E-13
chromatin binding SMART molecular function 1.8E-20
DNA (cytosine-5-)-methyltransferase activity PIRSF molecular function 0.0
nucleus PIRSF cellular component 0.0
methyltransferase activity Pfam molecular function 1.6E-47
zinc ion binding Pfam molecular function 1.1E-13
C-5 methylation of cytosine PIRSF biological process 0.0

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