Gene Card
Best human hits
ACLY; SUCLG1; SUCLG2
Species
Unique Gene ID
Cisavi.g00000608
Gene Model ID
Cisavi.CG.ENS81.R1.4415089-4432955
Location
R1:4415088..4432955
Transcript Models and Sequences
Cisavi.CG.ENS81.R1.4415089-4432955.19586.t
Cisavi.CG.ENS81.R1.4415089-4432955.19587.t
Cisavi.CG.ENS81.R1.4415089-4432955.19588.t
Cisavi.CG.ENS81.R1.4415089-4432955.19589.t
Cisavi.CG.ENS81.R1.4415089-4432955.19590.t
Cisavi.CG.ENS81.R1.4415089-4432955.19591.t
Cisavi.CG.ENS81.R1.4415089-4432955.19592.t
n/a
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Click here to see the tree inference method
InterPro
16 results
| IPR Term | Analysis | Definition |
|---|---|---|
| CoA-bd | Pfam | CoA-binding |
| Succinyl-CoA_synth-like | Gene3D | Succinyl-CoA synthetase-like |
| Citrate_synth-like_sm_a-sub | Gene3D | Citrate synthase-like, small alpha subdomain |
| ATP-grasp_succ-CoA_synth-type | Pfam | ATP-grasp fold, succinyl-CoA synthetase-type |
| Citrate_synthase_sf | SUPERFAMILY | Citrate synthase superfamily |
| Citrate_synthase | Pfam | Citrate synthase |
| CoA_ligase | Pfam | ATP-citrate lyase/succinyl-CoA ligase |
| Citrt_syn/SCS-alpha_CS | ProSitePatterns | ATP-citrate lyase/succinyl-CoA ligase, conserved site |
| Citrate-bd | Pfam | ATP-citrate synthase, citrate-binding domain |
| NAD(P)-bd_dom_sf | SUPERFAMILY | NAD(P)-binding domain superfamily |
| ATP_grasp_subdomain_1 | Gene3D | ATP-grasp fold, subdomain 1 |
| ATP-citrate_synthase | PIRSF | ATP-citrate synthase |
| Succinyl-CoA_synth-like | SUPERFAMILY | Succinyl-CoA synthetase-like |
| Succ-CoA_synthase_bsu_CS | ProSitePatterns | Succinyl-CoA synthetase, beta subunit, conserved site |
| CoA-bd | SMART | CoA-binding |
| Cit_synth/succinyl-CoA_lig_AS | ProSitePatterns | ATP-citrate lyase/succinyl-CoA ligase, active site |
| GO Term | Annotation Origin | Type |
|---|
GO (Orthology)
29 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
|---|---|---|
| nucleotide binding | Hs | molecular function |
| catalytic activity | Hs | molecular function |
| ATP citrate synthase activity | Hs | molecular function |
| protein binding | Hs | molecular function |
| ATP binding | Hs | molecular function |
| extracellular region | Hs | cellular component |
| nucleoplasm | Hs | cellular component |
| cytoplasm | Hs | cellular component |
| cytosol | Hs | cellular component |
| plasma membrane | Hs | cellular component |
| acetyl-CoA biosynthetic process | Hs | biological process |
| citrate metabolic process | Hs | biological process |
| oxaloacetate metabolic process | Hs | biological process |
| lipid metabolic process | Hs | biological process |
| fatty acid biosynthetic process | Hs | biological process |
| cholesterol biosynthetic process | Hs | biological process |
| metabolic process | Hs | biological process |
| lipid biosynthetic process | Hs | biological process |
| citrate lyase complex | Hs | cellular component |
| coenzyme A metabolic process | Hs | biological process |
| membrane | Hs | cellular component |
| transferase activity | Hs | molecular function |
| lyase activity | Hs | molecular function |
| azurophil granule lumen | Hs | cellular component |
| metal ion binding | Hs | molecular function |
| transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | Hs | molecular function |
| cofactor binding | Hs | molecular function |
| extracellular exosome | Hs | cellular component |
| ficolin-1-rich granule lumen | Hs | cellular component |
GO (Blast)
32 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
|---|---|---|---|---|
| nucleotide binding | Hs | molecular function | 1610 | 0.0 |
| magnesium ion binding | Hs | molecular function | 52.8 | 7.75e-07 |
| RNA binding | Hs | molecular function | 66.2 | 2.83e-11 |
| catalytic activity | Hs | molecular function | 1610 | 0.0 |
| ATP citrate synthase activity | Hs | molecular function | 1610 | 0.0 |
| succinate-CoA ligase (ADP-forming) activity | Hs | molecular function | 66.2 | 2.83e-11 |
| succinate-CoA ligase (GDP-forming) activity | Hs | molecular function | 66.2 | 2.83e-11 |
| protein binding | Hs | molecular function | 1610 | 0.0 |
| ATP binding | Hs | molecular function | 1610 | 0.0 |
| GTP binding | Hs | molecular function | 52.8 | 7.75e-07 |
| extracellular region | Hs | cellular component | 1610 | 0.0 |
| nucleoplasm | Hs | cellular component | 1610 | 0.0 |
| cytoplasm | Hs | cellular component | 1610 | 0.0 |
| mitochondrion | Hs | cellular component | 66.2 | 2.83e-11 |
| mitochondrial inner membrane | Hs | cellular component | 66.2 | 2.83e-11 |
| mitochondrial matrix | Hs | cellular component | 66.2 | 2.83e-11 |
| cytosol | Hs | cellular component | 1610 | 0.0 |
| plasma membrane | Hs | cellular component | 1610 | 0.0 |
| citrate lyase complex | Hs | cellular component | 1610 | 0.0 |
| membrane | Hs | cellular component | 1610 | 0.0 |
| transferase activity | Hs | molecular function | 1610 | 0.0 |
| lyase activity | Hs | molecular function | 1610 | 0.0 |
| ligase activity | Hs | molecular function | 66.2 | 2.83e-11 |
| GDP binding | Hs | molecular function | 52.8 | 7.75e-07 |
| azurophil granule lumen | Hs | cellular component | 1610 | 0.0 |
| succinate-CoA ligase complex (GDP-forming) | Hs | cellular component | 52.8 | 7.75e-07 |
| metal ion binding | Hs | molecular function | 1610 | 0.0 |
| transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | Hs | molecular function | 1610 | 0.0 |
| protein heterodimerization activity | Hs | molecular function | 52.8 | 7.75e-07 |
| cofactor binding | Hs | molecular function | 1610 | 0.0 |
| extracellular exosome | Hs | cellular component | 1610 | 0.0 |
| ficolin-1-rich granule lumen | Hs | cellular component | 1610 | 0.0 |
GO (InterProScan)
8 results
| GO Term | Analysis | Type | e-value |
|---|---|---|---|
| catalytic activity | Pfam | molecular function | 1.1E-15 |
| ATP citrate synthase activity | PIRSF | molecular function | 0.0 |
| ATP binding | Gene3D | molecular function | 2.4E-93 |
| acetyl-CoA biosynthetic process | PIRSF | biological process | 0.0 |
| citrate metabolic process | PIRSF | biological process | 0.0 |
| metabolic process | Pfam | biological process | 1.1E-15 |
| transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer | SUPERFAMILY | molecular function | 8.64E-80 |
| cofactor binding | Pfam | molecular function | 2.8E-13 |
