Gene Card
Best human hits
SIRT2; SIRT3
Species
Unique Gene ID
Boschl.g00005724
Gene Model ID
Boschl.CG.Botznik2013.chrUn.g05724
Location
chrUn:37998632..38004366
Transcript Models and Sequences
n/a
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.
Click here to see the tree inference method
InterPro
3 results
| IPR Term | Analysis | Definition |
|---|---|---|
| Sirtuin | Pfam | Sirtuin family |
| Ssirtuin_cat_dom | ProSiteProfiles | Sirtuin family, catalytic core domain |
| DHS-like_NAD/FAD-binding_dom | SUPERFAMILY | DHS-like NAD/FAD-binding domain superfamily |
| GO Term | Annotation Origin | Type |
|---|
GO (Orthology)
22 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
|---|---|---|
| NAD+ ADP-ribosyltransferase activity | Hs | molecular function |
| protein binding | Hs | molecular function |
| mitochondrion | Hs | cellular component |
| mitochondrial matrix | Hs | cellular component |
| protein ADP-ribosylation | Hs | biological process |
| protein deacetylation | Hs | biological process |
| mitochondrion organization | Hs | biological process |
| aging | Hs | biological process |
| zinc ion binding | Hs | molecular function |
| aerobic respiration | Hs | biological process |
| histone deacetylation | Hs | biological process |
| hydrolase activity | Hs | molecular function |
| NAD-dependent histone deacetylase activity | Hs | molecular function |
| enzyme binding | Hs | molecular function |
| positive regulation of insulin secretion | Hs | biological process |
| macromolecular complex | Hs | cellular component |
| NAD-dependent protein deacetylase activity | Hs | molecular function |
| sequence-specific DNA binding | Hs | molecular function |
| metal ion binding | Hs | molecular function |
| negative regulation of ERK1 and ERK2 cascade | Hs | biological process |
| NAD+ binding | Hs | molecular function |
| negative regulation of reactive oxygen species metabolic process | Hs | biological process |
GO (Blast)
52 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
|---|---|---|---|---|
| chromosome, telomeric region | Hs | cellular component | 151 | 5.81e-44 |
| chromatin binding | Hs | molecular function | 151 | 5.81e-44 |
| NAD+ ADP-ribosyltransferase activity | Hs | molecular function | 161 | 1.19e-47 |
| histone deacetylase activity | Hs | molecular function | 151 | 5.81e-44 |
| protein binding | Hs | molecular function | 161 | 1.19e-47 |
| nucleus | Hs | cellular component | 151 | 5.81e-44 |
| chromatin silencing complex | Hs | cellular component | 151 | 5.81e-44 |
| chromosome | Hs | cellular component | 151 | 5.81e-44 |
| nuclear heterochromatin | Hs | cellular component | 151 | 5.81e-44 |
| nucleolus | Hs | cellular component | 151 | 5.81e-44 |
| cytoplasm | Hs | cellular component | 151 | 5.81e-44 |
| mitochondrion | Hs | cellular component | 161 | 1.19e-47 |
| mitochondrial matrix | Hs | cellular component | 161 | 1.19e-47 |
| centrosome | Hs | cellular component | 151 | 5.81e-44 |
| centriole | Hs | cellular component | 151 | 5.81e-44 |
| microtubule organizing center | Hs | cellular component | 151 | 5.81e-44 |
| spindle | Hs | cellular component | 151 | 5.81e-44 |
| cytosol | Hs | cellular component | 151 | 5.81e-44 |
| cytoskeleton | Hs | cellular component | 151 | 5.81e-44 |
| microtubule | Hs | cellular component | 151 | 5.81e-44 |
| plasma membrane | Hs | cellular component | 151 | 5.81e-44 |
| transcription factor binding | Hs | molecular function | 151 | 5.81e-44 |
| zinc ion binding | Hs | molecular function | 161 | 1.19e-47 |
| membrane | Hs | cellular component | 151 | 5.81e-44 |
| hydrolase activity | Hs | molecular function | 161 | 1.19e-47 |
| NAD-dependent histone deacetylase activity | Hs | molecular function | 161 | 1.19e-47 |
| enzyme binding | Hs | molecular function | 161 | 1.19e-47 |
| growth cone | Hs | cellular component | 151 | 5.81e-44 |
| midbody | Hs | cellular component | 151 | 5.81e-44 |
| macromolecular complex | Hs | cellular component | 161 | 1.19e-47 |
| paranodal junction | Hs | cellular component | 151 | 5.81e-44 |
| paranode region of axon | Hs | cellular component | 151 | 5.81e-44 |
| protein deacetylase activity | Hs | molecular function | 151 | 5.81e-44 |
| NAD-dependent protein deacetylase activity | Hs | molecular function | 161 | 1.19e-47 |
| histone acetyltransferase binding | Hs | molecular function | 151 | 5.81e-44 |
| histone deacetylase binding | Hs | molecular function | 151 | 5.81e-44 |
| tubulin deacetylase activity | Hs | molecular function | 151 | 5.81e-44 |
| cell projection | Hs | cellular component | 151 | 5.81e-44 |
| ubiquitin binding | Hs | molecular function | 151 | 5.81e-44 |
| perikaryon | Hs | cellular component | 151 | 5.81e-44 |
| myelin sheath | Hs | cellular component | 151 | 5.81e-44 |
| lateral loop | Hs | cellular component | 151 | 5.81e-44 |
| Schmidt-Lanterman incisure | Hs | cellular component | 151 | 5.81e-44 |
| sequence-specific DNA binding | Hs | molecular function | 161 | 1.19e-47 |
| juxtaparanode region of axon | Hs | cellular component | 151 | 5.81e-44 |
| metal ion binding | Hs | molecular function | 161 | 1.19e-47 |
| NAD-dependent histone deacetylase activity (H4-K16 specific) | Hs | molecular function | 151 | 5.81e-44 |
| perinuclear region of cytoplasm | Hs | cellular component | 151 | 5.81e-44 |
| NAD+ binding | Hs | molecular function | 161 | 1.19e-47 |
| mitotic spindle | Hs | cellular component | 151 | 5.81e-44 |
| meiotic spindle | Hs | cellular component | 151 | 5.81e-44 |
| glial cell projection | Hs | cellular component | 151 | 5.81e-44 |
GO (InterProScan)
1 result
| GO Term | Analysis | Type | e-value |
|---|---|---|---|
| NAD+ binding | Pfam | molecular function | 3.9E-21 |
