IPR Term	Analysis	Definition
Proteasome_bsu_CS	ProSitePatterns	Proteasome beta-type subunit, conserved site
Pept_T1A_subB	PRINTS	Peptidase T1A, proteasome beta-subunit
Proteasome_suB-type	ProSiteProfiles	Proteasome B-type subunit
Proteasome_beta_5	PANTHER	Proteasome subunit beta 5
Ntn_hydrolases_N	Gene3D	Nucleophile aminohydrolases, N-terminal
Proteasome_sua/b	Pfam	Proteasome, subunit alpha/beta
Ntn_hydrolases_N	SUPERFAMILY	Nucleophile aminohydrolases, N-terminal

GO Term	Annotation Origin	Type
protein polyubiquitination	Orthology	biological process
immune system process	Orthology	biological process
endopeptidase activity	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
centrosome	Orthology	cellular component
cytosol	Orthology	cellular component
proteolysis	Orthology	biological process
response to oxidative stress	Orthology	biological process
peptidase activity	Orthology	molecular function
hydrolase activity	Orthology	molecular function
cell differentiation	Orthology	biological process
transmembrane transport	Orthology	biological process
extracellular exosome	Orthology	cellular component
negative regulation of canonical Wnt signaling pathway	Orthology	biological process
positive regulation of canonical Wnt signaling pathway	Orthology	biological process
intracellular signal transduction	Orthology	biological process
protein phosphorylation	Orthology	biological process
intracellular part	Orthology	cellular component
macromolecular complex	Orthology	cellular component
G2/M transition of mitotic cell cycle	Orthology	biological process
peptidase activity, acting on L-amino acid peptides	Orthology	molecular function
cytokine-mediated signaling pathway	Orthology	biological process
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
cell surface receptor signaling pathway	Orthology	biological process
immune response	Orthology	biological process
mRNA catabolic process	Orthology	biological process
cellular protein modification process	Orthology	biological process
cell-cell signaling	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
animal organ development	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
MAPK cascade	Hs	biological process
protein polyubiquitination	Hs	biological process
proteasome complex	Hs	cellular component
immune system process	Hs	biological process
endopeptidase activity	Hs	molecular function
threonine-type endopeptidase activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
centrosome	Hs	cellular component
cytosol	Hs	cellular component
proteasome core complex	Hs	cellular component
proteolysis	Hs	biological process
response to oxidative stress	Hs	biological process
peptidase activity	Hs	molecular function
negative regulation of G2/M transition of mitotic cell cycle	Hs	biological process
viral process	Hs	biological process
protein deubiquitination	Hs	biological process
hydrolase activity	Hs	molecular function
proteasome core complex, beta-subunit complex	Hs	cellular component
antigen processing and presentation	Hs	biological process
cell differentiation	Hs	biological process
anaphase-promoting complex-dependent catabolic process	Hs	biological process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Hs	biological process
tumor necrosis factor-mediated signaling pathway	Hs	biological process
NIK/NF-kappaB signaling	Hs	biological process
Fc-epsilon receptor signaling pathway	Hs	biological process
proteasome-mediated ubiquitin-dependent protein catabolic process	Hs	biological process
regulation of mRNA stability	Hs	biological process
post-translational protein modification	Hs	biological process
fat cell differentiation	Hs	biological process
T cell receptor signaling pathway	Hs	biological process
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Hs	biological process
proteolysis involved in cellular protein catabolic process	Hs	biological process
transmembrane transport	Hs	biological process
Wnt signaling pathway, planar cell polarity pathway	Hs	biological process
extracellular exosome	Hs	cellular component
interleukin-1-mediated signaling pathway	Hs	biological process
negative regulation of canonical Wnt signaling pathway	Hs	biological process
positive regulation of canonical Wnt signaling pathway	Hs	biological process
regulation of hematopoietic stem cell differentiation	Hs	biological process
spermatoproteasome complex	Hs	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
proteasome complex	Hs	cellular component	341	4.36e-119
endopeptidase activity	Hs	molecular function	341	4.36e-119
threonine-type endopeptidase activity	Hs	molecular function	341	4.36e-119
protein binding	Hs	molecular function	341	4.36e-119
nucleus	Hs	cellular component	341	4.36e-119
nucleoplasm	Hs	cellular component	341	4.36e-119
cytoplasm	Hs	cellular component	341	4.36e-119
centrosome	Hs	cellular component	341	4.36e-119
cytosol	Hs	cellular component	341	4.36e-119
proteasome core complex	Hs	cellular component	341	4.36e-119
peptidase activity	Hs	molecular function	341	4.36e-119
hydrolase activity	Hs	molecular function	341	4.36e-119
proteasome core complex, beta-subunit complex	Hs	cellular component	341	4.36e-119
extracellular exosome	Hs	cellular component	341	4.36e-119
spermatoproteasome complex	Hs	cellular component	306	2.81e-105

GO Term	Analysis	Type	e-value
proteasome complex	PANTHER	cellular component	2.0E-126
endopeptidase activity	PRINTS	molecular function	6.7E-20
threonine-type endopeptidase activity	PANTHER	molecular function	2.0E-126
proteasome core complex	Pfam	cellular component	2.8E-48
proteasome-mediated ubiquitin-dependent protein catabolic process	PANTHER	biological process	2.0E-126
proteolysis involved in cellular protein catabolic process	Pfam	biological process	2.8E-48