Gene Card
Best human hits
IGF1R; INSR; INSRR
Species
Unique Gene ID
Phmamm.g00017965
Gene Model ID
Phmamm.CG.MTP2014.S3721.g17965
Location
S3721:4519..8110
Transcript Models and Sequences
AHC0AAA11YJ21
Plate: Plate_11_J21
AHC0AAA45YH11
Plate: Plate_45_H11
AHC0AAA66YL06
Plate: Plate_66_L06
AHC0AAA92YF15
Plate: Plate_92_F15
AHC0AAA92YN06
Plate: Plate_92_N06
AHC0AAA161YA14
Plate: Plate_161_A14
AHC0AAA233YN05
Plate: Plate_233_N05
AHC0AAA92YF13
Plate: Plate_92_F13
AHC0AAA92YP08
Plate: Plate_92_P08
n/a
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IPR Term | Analysis | Definition |
---|---|---|
Ser-Thr/Tyr_kinase_cat_dom | Pfam | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Kinase-like_dom_sf | SUPERFAMILY | Protein kinase-like domain superfamily |
Prot_kinase_dom | ProSiteProfiles | Protein kinase domain |
Tyr_kinase_rcpt_2_CS | ProSitePatterns | Tyrosine-protein kinase, receptor class II, conserved site |
Ser-Thr/Tyr_kinase_cat_dom | PRINTS | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Tyr_kinase_AS | ProSitePatterns | Tyrosine-protein kinase, active site |
Tyr_kinase_cat_dom | SMART | Tyrosine-protein kinase, catalytic domain |
GO Term | Annotation Origin | Type |
---|---|---|
nucleotide binding | Blast | molecular function |
protein kinase activity | Blast | molecular function |
protein binding | Blast | molecular function |
ATP binding | Blast | molecular function |
GTP binding | Blast | molecular function |
intracellular | Blast | cellular component |
nuclear envelope | Blast | cellular component |
plasma membrane | Blast | cellular component |
integral component of plasma membrane | Blast | cellular component |
protein phosphorylation | InterProScan | biological process |
membrane | Blast | cellular component |
integral component of membrane | Blast | cellular component |
kinase activity | Blast | molecular function |
transferase activity | Blast | molecular function |
nuclear lumen | Blast | cellular component |
identical protein binding | Blast | molecular function |
intracellular membrane-bounded organelle | Blast | cellular component |
macromolecular complex binding | Blast | molecular function |
extracellular exosome | Blast | cellular component |
binding | Blast | molecular function |
transmembrane signaling receptor activity | Blast | molecular function |
cell surface receptor signaling pathway | Blast | biological process |
cellular response to organic substance | Blast | biological process |
receptor binding | Blast | molecular function |
macromolecular complex | Blast | cellular component |
membrane raft | Blast | cellular component |
plasma membrane region | Blast | cellular component |
plasma membrane part | Blast | cellular component |
cell surface | Blast | cellular component |
intracellular organelle part | Blast | cellular component |
whole membrane | Blast | cellular component |
endosome | Blast | cellular component |
bounding membrane of organelle | Blast | cellular component |
cell projection membrane | Blast | cellular component |
cell leading edge | Blast | cellular component |
neuron projection | Blast | cellular component |
neuronal cell body | Blast | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
nucleotide binding | Hs | molecular function | 301 | 2.43e-93 |
amyloid-beta binding | Hs | molecular function | 301 | 2.43e-93 |
protein kinase activity | Hs | molecular function | 301 | 2.43e-93 |
protein tyrosine kinase activity | Hs | molecular function | 301 | 2.43e-93 |
transmembrane receptor protein tyrosine kinase activity | Hs | molecular function | 301 | 2.43e-93 |
signal transducer, downstream of receptor, with protein tyrosine kinase activity | Hs | molecular function | 301 | 2.43e-93 |
insulin-activated receptor activity | Hs | molecular function | 301 | 2.43e-93 |
insulin-like growth factor-activated receptor activity | Hs | molecular function | 292 | 5.26e-90 |
insulin receptor binding | Hs | molecular function | 292 | 5.26e-90 |
insulin-like growth factor receptor binding | Hs | molecular function | 301 | 2.43e-93 |
protein binding | Hs | molecular function | 301 | 2.43e-93 |
insulin-like growth factor binding | Hs | molecular function | 292 | 5.26e-90 |
ATP binding | Hs | molecular function | 301 | 2.43e-93 |
GTP binding | Hs | molecular function | 301 | 2.43e-93 |
intracellular | Hs | cellular component | 301 | 2.43e-93 |
nuclear envelope | Hs | cellular component | 301 | 2.43e-93 |
plasma membrane | Hs | cellular component | 301 | 2.43e-93 |
integral component of plasma membrane | Hs | cellular component | 301 | 2.43e-93 |
insulin receptor complex | Hs | cellular component | 301 | 2.43e-93 |
caveola | Hs | cellular component | 301 | 2.43e-93 |
external side of plasma membrane | Hs | cellular component | 301 | 2.43e-93 |
endosome membrane | Hs | cellular component | 301 | 2.43e-93 |
membrane | Hs | cellular component | 301 | 2.43e-93 |
integral component of membrane | Hs | cellular component | 301 | 2.43e-93 |
kinase activity | Hs | molecular function | 301 | 2.43e-93 |
transferase activity | Hs | molecular function | 301 | 2.43e-93 |
protein domain specific binding | Hs | molecular function | 301 | 2.43e-93 |
nuclear lumen | Hs | cellular component | 301 | 2.43e-93 |
insulin-like growth factor I binding | Hs | molecular function | 301 | 2.43e-93 |
insulin-like growth factor II binding | Hs | molecular function | 301 | 2.43e-93 |
dendrite membrane | Hs | cellular component | 301 | 2.43e-93 |
neuronal cell body membrane | Hs | cellular component | 301 | 2.43e-93 |
alphav-beta3 integrin-IGF-1-IGF1R complex | Hs | cellular component | 292 | 5.26e-90 |
identical protein binding | Hs | molecular function | 292 | 5.26e-90 |
intracellular membrane-bounded organelle | Hs | cellular component | 292 | 5.26e-90 |
receptor complex | Hs | cellular component | 301 | 2.43e-93 |
phosphatidylinositol 3-kinase binding | Hs | molecular function | 301 | 2.43e-93 |
insulin binding | Hs | molecular function | 301 | 2.43e-93 |
insulin receptor substrate binding | Hs | molecular function | 301 | 2.43e-93 |
macromolecular complex binding | Hs | molecular function | 301 | 2.43e-93 |
PTB domain binding | Hs | molecular function | 301 | 2.43e-93 |
extracellular exosome | Hs | cellular component | 301 | 2.43e-93 |
amyloid-beta complex | Hs | cellular component | 301 | 2.43e-93 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
protein kinase activity | Pfam | molecular function | 4.5E-75 |
protein tyrosine kinase activity | SMART | molecular function | 8.8E-74 |
transmembrane receptor protein tyrosine kinase activity | ProSitePatterns | molecular function | |
ATP binding | ProSiteProfiles | molecular function | 28.075 |
protein phosphorylation | Pfam | biological process | 4.5E-75 |
transmembrane receptor protein tyrosine kinase signaling pathway | ProSitePatterns | biological process | |
membrane | ProSitePatterns | cellular component |