IPR Term	Analysis	Definition
Endo/exonu/phosph_ase_sf	SUPERFAMILY	Endonuclease/exonuclease/phosphatase superfamily
IPPc	SMART	Inositol polyphosphate-related phosphatase
Endo/exonu/phosph_ase_sf	Gene3D	Endonuclease/exonuclease/phosphatase superfamily

GO Term	Annotation Origin	Type
nucleic acid binding	Blast	molecular function
RNA binding	Blast	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
cytoplasm	Orthology	cellular component
endoplasmic reticulum	Orthology	cellular component
cytosol	Orthology	cellular component
cytoskeleton	Blast	cellular component
plasma membrane	Orthology	cellular component
G-protein coupled receptor signaling pathway	Orthology	biological process
membrane	Orthology	cellular component
dephosphorylation	Orthology	biological process
hydrolase activity	Orthology	molecular function
axon	Orthology	cellular component
cell projection	Orthology	cellular component
neuron projection	Orthology	cellular component
membrane raft	Blast	cellular component
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
perinuclear region of cytoplasm	Orthology	cellular component
plasma membrane region	Orthology	cellular component
cell leading edge	Orthology	cellular component
protein phosphorylation	Orthology	biological process
binding	Orthology	molecular function
G-protein coupled receptor activity	Orthology	molecular function
Golgi apparatus part	Orthology	cellular component
regulation of catalytic activity	Orthology	biological process
protein kinase activity	Orthology	molecular function
cellular biosynthetic process	Orthology	biological process
phosphate-containing compound metabolic process	Orthology	biological process
neuron projection development	Orthology	biological process
organelle organization	Orthology	biological process
cell projection part	Orthology	cellular component
microtubule-based process	Orthology	biological process
cell projection membrane	Orthology	cellular component
response to organic substance	Orthology	biological process
cellular response to organic substance	Orthology	biological process
intracellular signal transduction	Orthology	biological process
protein serine/threonine kinase activity	Orthology	molecular function
negative regulation of signal transduction	Orthology	biological process
regulation of RNA biosynthetic process	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
organic substance metabolic process	Orthology	biological process
metal ion transport	Orthology	biological process
protein localization to membrane	Orthology	biological process
cell projection assembly	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
ruffle	Hs	cellular component
negative regulation of protein phosphorylation	Hs	biological process
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	Hs	molecular function
inositol-polyphosphate 5-phosphatase activity	Hs	molecular function
vasopressin receptor activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
cytoplasm	Hs	cellular component
endoplasmic reticulum	Hs	cellular component
trans-Golgi network	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
negative regulation of protein kinase activity	Hs	biological process
phosphatidylinositol biosynthetic process	Hs	biological process
G-protein coupled receptor signaling pathway	Hs	biological process
negative regulation of neuron projection development	Hs	biological process
membrane	Hs	cellular component
dephosphorylation	Hs	biological process
inositol bisphosphate phosphatase activity	Hs	molecular function
hydrolase activity	Hs	molecular function
SH3 domain binding	Hs	molecular function
actin cytoskeleton organization	Hs	biological process
growth cone	Hs	cellular component
negative regulation of microtubule polymerization	Hs	biological process
ruffle membrane	Hs	cellular component
response to insulin	Hs	biological process
cellular response to insulin stimulus	Hs	biological process
cellular response to hormone stimulus	Hs	biological process
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	Hs	molecular function
phosphatidylinositol trisphosphate phosphatase activity	Hs	molecular function
phosphatidylinositol phosphate 5-phosphatase activity	Hs	molecular function
positive regulation of urine volume	Hs	biological process
lipid phosphatase activity	Hs	molecular function
glucose homeostasis	Hs	biological process
neuron projection	Hs	cellular component
dendritic shaft	Hs	cellular component
negative regulation of MAP kinase activity	Hs	biological process
negative regulation by host of viral transcription	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
inositol trisphosphate phosphatase activity	Hs	molecular function
negative regulation of insulin receptor signaling pathway	Hs	biological process
inositol phosphate dephosphorylation	Hs	biological process
phosphatidylinositol dephosphorylation	Hs	biological process
perinuclear region of cytoplasm	Hs	cellular component
negative regulation of stress fiber assembly	Hs	biological process
negative regulation of protein kinase B signaling	Hs	biological process
negative regulation of calcium ion transport	Hs	biological process
inositol-1,4,5-trisphosphate 5-phosphatase activity	Hs	molecular function
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	Hs	molecular function
cellular response to tumor necrosis factor	Hs	biological process
cellular response to epidermal growth factor stimulus	Hs	biological process
protein localization to plasma membrane	Hs	biological process
ruffle assembly	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
ruffle	Hs	cellular component	202	3.98e-58
nucleic acid binding	Hs	molecular function	145	2.96e-38
RNA binding	Hs	molecular function	145	2.96e-38
phosphatidylinositol-3-phosphatase activity	Hs	molecular function	145	2.96e-38
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	Hs	molecular function	202	3.98e-58
inositol-polyphosphate 5-phosphatase activity	Hs	molecular function	202	3.98e-58
vasopressin receptor activity	Hs	molecular function	195	2.48e-58
protein binding	Hs	molecular function	202	3.98e-58
nucleus	Hs	cellular component	195	2.48e-58
cytoplasm	Hs	cellular component	202	3.98e-58
endoplasmic reticulum	Hs	cellular component	195	2.48e-58
trans-Golgi network	Hs	cellular component	195	2.48e-58
cytosol	Hs	cellular component	202	3.98e-58
cytoskeleton	Hs	cellular component	145	2.96e-38
plasma membrane	Hs	cellular component	202	3.98e-58
membrane	Hs	cellular component	195	2.48e-58
inositol bisphosphate phosphatase activity	Hs	molecular function	195	2.48e-58
hydrolase activity	Hs	molecular function	202	3.98e-58
SH3 domain binding	Hs	molecular function	202	3.98e-58
axon	Hs	cellular component	145	2.96e-38
growth cone	Hs	cellular component	202	3.98e-58
ruffle membrane	Hs	cellular component	195	2.48e-58
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	Hs	molecular function	202	3.98e-58
phosphatidylinositol trisphosphate phosphatase activity	Hs	molecular function	195	2.48e-58
phosphatidylinositol phosphate 5-phosphatase activity	Hs	molecular function	195	2.48e-58
phosphatidylinositol phosphate 4-phosphatase activity	Hs	molecular function	145	2.96e-38
lipid phosphatase activity	Hs	molecular function	195	2.48e-58
phosphoric ester hydrolase activity	Hs	molecular function	145	2.96e-38
cell projection	Hs	cellular component	145	2.96e-38
neuron projection	Hs	cellular component	195	2.48e-58
dendritic shaft	Hs	cellular component	202	3.98e-58
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	Hs	molecular function	145	2.96e-38
membrane raft	Hs	cellular component	145	2.96e-38
inositol trisphosphate phosphatase activity	Hs	molecular function	195	2.48e-58
perinuclear region of cytoplasm	Hs	cellular component	195	2.48e-58
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	Hs	molecular function	145	2.96e-38
inositol-1,4,5-trisphosphate 5-phosphatase activity	Hs	molecular function	202	3.98e-58
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	Hs	molecular function	202	3.98e-58

GO Term	Analysis	Type	e-value
phosphatidylinositol dephosphorylation	SMART	biological process	3.5E-27