IPR Term	Analysis	Definition
Guanylate_kinase_CS	ProSitePatterns	Guanylate kinase, conserved site
PDZ_sf	SUPERFAMILY	PDZ superfamily
PDZ	SMART	PDZ domain
PDZ	ProSiteProfiles	PDZ domain
SH3_domain	SMART	SH3 domain
SH3-like_dom_sf	SUPERFAMILY	SH3-like domain superfamily
GK/Ca_channel_bsu	SMART	Guanylate kinase/L-type calcium channel beta subunit
PDZ	Pfam	PDZ domain
P-loop_NTPase	SUPERFAMILY	P-loop containing nucleoside triphosphate hydrolase
GK/Ca_channel_bsu	Pfam	Guanylate kinase/L-type calcium channel beta subunit
SH3_domain	ProSiteProfiles	SH3 domain
SH3_domain	Pfam	SH3 domain
Guanylate_kin-like_dom	ProSiteProfiles	Guanylate kinase-like domain
DLG1-like	PIRSF	Disks large 1-like

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
protein binding	Orthology	molecular function
extracellular space	Orthology	cellular component
nucleus	Orthology	cellular component
cytoplasm	Orthology	cellular component
endoplasmic reticulum	Orthology	cellular component
endoplasmic reticulum membrane	Orthology	cellular component
Golgi apparatus	Orthology	cellular component
cytosol	Orthology	cellular component
microtubule	Orthology	cellular component
plasma membrane	Orthology	cellular component
protein dephosphorylation	Orthology	biological process
chemical synaptic transmission	Orthology	biological process
nervous system development	Orthology	biological process
protein C-terminus binding	Orthology	molecular function
cytoskeletal protein binding	Orthology	molecular function
protein localization	Orthology	biological process
positive regulation of cell proliferation	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process
membrane	Orthology	cellular component
basolateral plasma membrane	Orthology	cellular component
apical plasma membrane	Orthology	cellular component
kinase binding	Orthology	molecular function
protein kinase binding	Orthology	molecular function
cell junction	Orthology	cellular component
axon	Orthology	cellular component
cell projection membrane	Orthology	cellular component
ubiquitin protein ligase binding	Orthology	molecular function
cell projection	Orthology	cellular component
neuronal cell body	Orthology	cellular component
membrane raft	Orthology	cellular component
synapse	Orthology	cellular component
postsynaptic membrane	Orthology	cellular component
perinuclear region of cytoplasm	Orthology	cellular component
extracellular exosome	Orthology	cellular component
signal transduction	Orthology	biological process
macromolecular complex binding	Orthology	molecular function
establishment of protein localization	Orthology	biological process
cell periphery	Orthology	cellular component
synaptic membrane	Orthology	cellular component
postsynapse	Orthology	cellular component
animal organ development	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
plasma membrane part	Orthology	cellular component
cell proliferation	Orthology	biological process
kinase activity	Orthology	molecular function
hydrolase activity	Orthology	molecular function
organelle organization	Orthology	biological process
cellular process	Orthology	biological process
integral component of plasma membrane	Orthology	cellular component
macromolecular complex	Orthology	cellular component
cell morphogenesis	Orthology	biological process
dephosphorylation	Orthology	biological process
organelle	Orthology	cellular component
neuron part	Orthology	cellular component
ion transport	Orthology	biological process
transmembrane transport	Orthology	biological process
metal ion transport	Orthology	biological process
molecular function regulator	Orthology	molecular function
monovalent inorganic cation transport	Orthology	biological process
sensory perception	Orthology	biological process
enzyme binding	Orthology	molecular function
cell projection part	Orthology	cellular component
microtubule-based process	Orthology	biological process
positive regulation of catalytic activity	Orthology	biological process
protein kinase activity	Orthology	molecular function
cellular protein localization	Orthology	biological process
receptor binding	Orthology	molecular function
myelin sheath	Orthology	cellular component
immune system process	Orthology	biological process
protein metabolic process	Orthology	biological process
protein localization to membrane	Orthology	biological process
cell adhesion molecule binding	Orthology	molecular function
phosphate-containing compound metabolic process	Orthology	biological process
nucleobase-containing compound metabolic process	Orthology	biological process
reproductive process	Orthology	biological process
system development	Orthology	biological process
anatomical structure development	Orthology	biological process
intracellular signal transduction	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
protein phosphorylation	Orthology	biological process
adherens junction	Orthology	cellular component
cell adhesion	Orthology	biological process
cell	Orthology	cellular component
nervous system process	Orthology	biological process
cytoplasmic vesicle	Orthology	cellular component
synapse part	Orthology	cellular component
endomembrane system	Orthology	cellular component
developmental process	Orthology	biological process
intracellular organelle part	Orthology	cellular component
whole membrane	Orthology	cellular component
bounding membrane of organelle	Orthology	cellular component
cytoplasmic part	Orthology	cellular component
cytoskeleton	Orthology	cellular component
intracellular part	Orthology	cellular component
neuron projection	Orthology	cellular component
regulation of signaling	Orthology	biological process
cell morphogenesis involved in neuron differentiation	Orthology	biological process
neuron projection morphogenesis	Orthology	biological process
membrane organization	Orthology	biological process
organelle part	Orthology	cellular component
cell surface receptor signaling pathway	Orthology	biological process
cation transport	Orthology	biological process
transmembrane signaling receptor activity	Orthology	molecular function
regulation of molecular function	Orthology	biological process
anion binding	Orthology	molecular function
regulation of signal transduction	Orthology	biological process
small molecule binding	Orthology	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
ureteric bud development	Hs	biological process
branching involved in ureteric bud morphogenesis	Hs	biological process
establishment of planar polarity	Hs	biological process
immunological synapse	Hs	cellular component
endothelial cell proliferation	Hs	biological process
lens development in camera-type eye	Hs	biological process
guanylate kinase activity	Hs	molecular function
phosphoprotein phosphatase activity	Hs	molecular function
protein binding	Hs	molecular function
basal lamina	Hs	cellular component
extracellular space	Hs	cellular component
nucleus	Hs	cellular component
cytoplasm	Hs	cellular component
endoplasmic reticulum	Hs	cellular component
endoplasmic reticulum membrane	Hs	cellular component
Golgi apparatus	Hs	cellular component
cytosol	Hs	cellular component
microtubule	Hs	cellular component
plasma membrane	Hs	cellular component
cell-cell junction	Hs	cellular component
bicellular tight junction	Hs	cellular component
protein dephosphorylation	Hs	biological process
actin filament organization	Hs	biological process
mitotic cell cycle checkpoint	Hs	biological process
establishment or maintenance of cell polarity	Hs	biological process
chemical synaptic transmission	Hs	biological process
nervous system development	Hs	biological process
protein C-terminus binding	Hs	molecular function
voltage-gated potassium channel complex	Hs	cellular component
cytoskeletal protein binding	Hs	molecular function
protein localization	Hs	biological process
positive regulation of cell proliferation	Hs	biological process
negative regulation of cell proliferation	Hs	biological process
ionotropic glutamate receptor complex	Hs	cellular component
regulation of cell shape	Hs	biological process
cytoplasmic side of plasma membrane	Hs	cellular component
negative regulation of phosphatase activity	Hs	biological process
postsynaptic density	Hs	cellular component
intercalated disc	Hs	cellular component
ligand-gated ion channel activity	Hs	molecular function
potassium channel regulator activity	Hs	molecular function
membrane	Hs	cellular component
viral process	Hs	biological process
basolateral plasma membrane	Hs	cellular component
apical plasma membrane	Hs	cellular component
lateral plasma membrane	Hs	cellular component
sensory perception of pain	Hs	biological process
kinase binding	Hs	molecular function
protein kinase binding	Hs	molecular function
phosphatase binding	Hs	molecular function
protein phosphatase binding	Hs	molecular function
protein domain specific binding	Hs	molecular function
cell junction	Hs	cellular component
PDZ domain binding	Hs	molecular function
axon	Hs	cellular component
growth cone	Hs	cellular component
peristalsis	Hs	biological process
positive regulation of actin filament polymerization	Hs	biological process
cortical actin cytoskeleton organization	Hs	biological process
astral microtubule organization	Hs	biological process
cell projection membrane	Hs	cellular component
mitogen-activated protein kinase kinase binding	Hs	molecular function
neuromuscular junction	Hs	cellular component
ubiquitin protein ligase binding	Hs	molecular function
regulation of myelination	Hs	biological process
activation of protein kinase activity	Hs	biological process
AMPA glutamate receptor complex	Hs	cellular component
protein complex scaffold activity	Hs	molecular function
node of Ranvier	Hs	cellular component
ion transmembrane transport	Hs	biological process
cellular protein complex localization	Hs	biological process
ionotropic glutamate receptor binding	Hs	molecular function
myelin sheath abaxonal region	Hs	cellular component
T cell activation	Hs	biological process
sarcolemma	Hs	cellular component
regulation of membrane potential	Hs	biological process
amyloid precursor protein metabolic process	Hs	biological process
cell projection	Hs	cellular component
neuronal cell body	Hs	cellular component
receptor clustering	Hs	biological process
dendritic shaft	Hs	cellular component
lateral loop	Hs	cellular component
cortical microtubule organization	Hs	biological process
juxtaparanode region of axon	Hs	cellular component
ion channel binding	Hs	molecular function
membrane raft	Hs	cellular component
establishment or maintenance of epithelial cell apical/basal polarity	Hs	biological process
synapse	Hs	cellular component
postsynaptic membrane	Hs	cellular component
cadherin binding	Hs	molecular function
negative regulation of mitotic cell cycle	Hs	biological process
GMP metabolic process	Hs	biological process
GDP metabolic process	Hs	biological process
perinuclear region of cytoplasm	Hs	cellular component
reproductive structure development	Hs	biological process
tissue morphogenesis	Hs	biological process
smooth muscle tissue development	Hs	biological process
negative regulation of epithelial cell proliferation	Hs	biological process
establishment of centrosome localization	Hs	biological process
negative regulation of protein kinase B signaling	Hs	biological process
hard palate development	Hs	biological process
positive regulation of protein tyrosine kinase activity	Hs	biological process
extracellular exosome	Hs	cellular component
negative regulation of ERK1 and ERK2 cascade	Hs	biological process
bicellular tight junction assembly	Hs	biological process
protein localization to plasma membrane	Hs	biological process
L27 domain binding	Hs	molecular function
MPP7-DLG1-LIN7 complex	Hs	cellular component
receptor localization to synapse	Hs	biological process
cell-cell adhesion	Hs	biological process
positive regulation of protein localization to plasma membrane	Hs	biological process
MAPK cascade	Hs	biological process
Ras guanyl-nucleotide exchange factor activity	Hs	molecular function
signal transduction	Hs	biological process
positive regulation of cytosolic calcium ion concentration	Hs	biological process
learning	Hs	biological process
synaptic vesicle	Hs	cellular component
synaptic vesicle maturation	Hs	biological process
dendrite	Hs	cellular component
endocytic vesicle membrane	Hs	cellular component
cortical cytoskeleton	Hs	cellular component
extrinsic component of cytoplasmic side of plasma membrane	Hs	cellular component
beta-1 adrenergic receptor binding	Hs	molecular function
D1 dopamine receptor binding	Hs	molecular function
P2Y1 nucleotide receptor binding	Hs	molecular function
dendrite cytoplasm	Hs	cellular component
acetylcholine receptor binding	Hs	molecular function
social behavior	Hs	biological process
protein localization to synapse	Hs	biological process
locomotory exploration behavior	Hs	biological process
dendritic spine	Hs	cellular component
cerebellar mossy fiber	Hs	cellular component
neuron projection terminus	Hs	cellular component
neuron spine	Hs	cellular component
macromolecular complex binding	Hs	molecular function
establishment of protein localization	Hs	biological process
regulation of long-term neuronal synaptic plasticity	Hs	biological process
positive regulation of synaptic transmission	Hs	biological process
neuromuscular process controlling balance	Hs	biological process
excitatory synapse	Hs	cellular component
dendritic spine morphogenesis	Hs	biological process
cell periphery	Hs	cellular component
synaptic membrane	Hs	cellular component
neuroligin family protein binding	Hs	molecular function
scaffold protein binding	Hs	molecular function
AMPA glutamate receptor clustering	Hs	biological process
postsynapse	Hs	cellular component
postsynaptic density membrane	Hs	cellular component
regulation of NMDA receptor activity	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
immunological synapse	Hs	cellular component	513	9.06e-168
guanylate kinase activity	Hs	molecular function	540	2.25e-177
phosphoprotein phosphatase activity	Hs	molecular function	513	9.06e-168
protein binding	Hs	molecular function	540	2.25e-177
basal lamina	Hs	cellular component	513	9.06e-168
extracellular space	Hs	cellular component	442	2.74e-141
nucleus	Hs	cellular component	513	9.06e-168
cytoplasm	Hs	cellular component	513	9.06e-168
endoplasmic reticulum	Hs	cellular component	513	9.06e-168
endoplasmic reticulum membrane	Hs	cellular component	513	9.06e-168
Golgi apparatus	Hs	cellular component	513	9.06e-168
cytosol	Hs	cellular component	540	2.25e-177
microtubule	Hs	cellular component	513	9.06e-168
plasma membrane	Hs	cellular component	540	2.25e-177
cell-cell junction	Hs	cellular component	513	9.06e-168
bicellular tight junction	Hs	cellular component	513	9.06e-168
protein C-terminus binding	Hs	molecular function	513	9.06e-168
voltage-gated potassium channel complex	Hs	cellular component	540	2.25e-177
cytoskeletal protein binding	Hs	molecular function	513	9.06e-168
ionotropic glutamate receptor complex	Hs	cellular component	540	2.25e-177
cytoplasmic side of plasma membrane	Hs	cellular component	513	9.06e-168
postsynaptic density	Hs	cellular component	540	2.25e-177
intercalated disc	Hs	cellular component	513	9.06e-168
ligand-gated ion channel activity	Hs	molecular function	513	9.06e-168
potassium channel regulator activity	Hs	molecular function	513	9.06e-168
membrane	Hs	cellular component	540	2.25e-177
basolateral plasma membrane	Hs	cellular component	513	9.06e-168
apical plasma membrane	Hs	cellular component	513	9.06e-168
lateral plasma membrane	Hs	cellular component	513	9.06e-168
kinase binding	Hs	molecular function	540	2.25e-177
protein kinase binding	Hs	molecular function	513	9.06e-168
phosphatase binding	Hs	molecular function	513	9.06e-168
protein phosphatase binding	Hs	molecular function	442	2.74e-141
protein domain specific binding	Hs	molecular function	442	2.74e-141
cell junction	Hs	cellular component	540	2.25e-177
PDZ domain binding	Hs	molecular function	442	2.74e-141
axon	Hs	cellular component	540	2.25e-177
growth cone	Hs	cellular component	442	2.74e-141
cell projection membrane	Hs	cellular component	513	9.06e-168
mitogen-activated protein kinase kinase binding	Hs	molecular function	513	9.06e-168
neuromuscular junction	Hs	cellular component	513	9.06e-168
ubiquitin protein ligase binding	Hs	molecular function	442	2.74e-141
AMPA glutamate receptor complex	Hs	cellular component	442	2.74e-141
protein complex scaffold activity	Hs	molecular function	513	9.06e-168
node of Ranvier	Hs	cellular component	513	9.06e-168
ionotropic glutamate receptor binding	Hs	molecular function	540	2.25e-177
myelin sheath abaxonal region	Hs	cellular component	513	9.06e-168
sarcolemma	Hs	cellular component	513	9.06e-168
cell projection	Hs	cellular component	540	2.25e-177
neuronal cell body	Hs	cellular component	442	2.74e-141
dendritic shaft	Hs	cellular component	442	2.74e-141
lateral loop	Hs	cellular component	513	9.06e-168
juxtaparanode region of axon	Hs	cellular component	540	2.25e-177
ion channel binding	Hs	molecular function	513	9.06e-168
membrane raft	Hs	cellular component	513	9.06e-168
synapse	Hs	cellular component	540	2.25e-177
postsynaptic membrane	Hs	cellular component	540	2.25e-177
cadherin binding	Hs	molecular function	513	9.06e-168
perinuclear region of cytoplasm	Hs	cellular component	513	9.06e-168
extracellular exosome	Hs	cellular component	513	9.06e-168
L27 domain binding	Hs	molecular function	513	9.06e-168
MPP7-DLG1-LIN7 complex	Hs	cellular component	513	9.06e-168

GO Term	Analysis	Type	e-value
protein binding	SUPERFAMILY	molecular function	1.31E-27