IPR Term	Analysis	Definition
HSF_fam	PANTHER	Heat shock transcription factor family
WH-like_DNA-bd_sf	Gene3D	Winged helix-like DNA-binding domain superfamily
HSF_DNA-bd	Pfam	Heat shock factor (HSF)-type, DNA-binding
HSF_DNA-bd	PRINTS	Heat shock factor (HSF)-type, DNA-binding
HSF_DNA-bd	SMART	Heat shock factor (HSF)-type, DNA-binding
WH_DNA-bd_sf	SUPERFAMILY	Winged helix DNA-binding domain superfamily
HSF2	PANTHER	Heat shock factor protein 2

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
RNA polymerase II regulatory region sequence-specific DNA binding	Orthology	molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Orthology	molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Orthology	molecular function
DNA binding	Orthology	molecular function
chromatin binding	Orthology	molecular function
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
transcription coactivator activity	Orthology	molecular function
transcription corepressor activity	Blast	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
centrosome	Orthology	cellular component
microtubule organizing center	Orthology	cellular component
cytosol	Orthology	cellular component
cytoskeleton	Orthology	cellular component
DNA repair	Orthology	biological process
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
regulation of transcription from RNA polymerase II promoter	Orthology	biological process
transcription from RNA polymerase II promoter	Orthology	biological process
mRNA processing	Orthology	biological process
protein phosphorylation	Orthology	biological process
defense response	Orthology	biological process
cellular response to DNA damage stimulus	Orthology	biological process
spermatogenesis	Orthology	biological process
positive regulation of cell proliferation	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process
positive regulation of gene expression	Orthology	biological process
negative regulation of gene expression	Orthology	biological process
nuclear speck	Blast	cellular component
protein kinase binding	Orthology	molecular function
response to lipopolysaccharide	Orthology	biological process
identical protein binding	Orthology	molecular function
protein homodimerization activity	Orthology	molecular function
sequence-specific DNA binding	Orthology	molecular function
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
protein heterodimerization activity	Orthology	molecular function
perinuclear region of cytoplasm	Orthology	cellular component
protein homooligomerization	Orthology	biological process
intracellular signal transduction	Orthology	biological process
intracellular organelle part	Orthology	cellular component
intracellular non-membrane-bounded organelle	Orthology	cellular component
macromolecular complex	Orthology	cellular component
cytoskeletal part	Orthology	cellular component
microtubule cytoskeleton	Orthology	cellular component
gamete generation	Orthology	biological process
mRNA metabolic process	Orthology	biological process
response to stress	Orthology	biological process
negative regulation of apoptotic process	Orthology	biological process
response to organic substance	Orthology	biological process
response to stimulus	Orthology	biological process
nuclear body	Orthology	cellular component
response to lipid	Orthology	biological process
cellular response to stress	Orthology	biological process
cellular response to organic substance	Orthology	biological process
developmental process	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
endopeptidase activity	Orthology	molecular function
positive regulation of hydrolase activity	Orthology	biological process
positive regulation of apoptotic process	Orthology	biological process
organic substance transport	Orthology	biological process
response to oxidative stress	Orthology	biological process
nuclear part	Orthology	cellular component
negative regulation of cell death	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
MAPK cascade	Hs	biological process
chromosome, centromeric region	Hs	cellular component
kinetochore	Hs	cellular component
condensed chromosome kinetochore	Hs	cellular component
euchromatin	Hs	cellular component
heterochromatin	Hs	cellular component
spindle pole	Hs	cellular component
RNA polymerase II regulatory region sequence-specific DNA binding	Hs	molecular function
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Hs	molecular function
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Hs	molecular function
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	Hs	molecular function
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Hs	molecular function
DNA binding	Hs	molecular function
chromatin binding	Hs	molecular function
transcription factor activity, sequence-specific DNA binding	Hs	molecular function
transcription coactivator activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
chromosome	Hs	cellular component
cytoplasm	Hs	cellular component
centrosome	Hs	cellular component
microtubule organizing center	Hs	cellular component
cytosol	Hs	cellular component
cytoskeleton	Hs	cellular component
DNA repair	Hs	biological process
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
regulation of transcription from RNA polymerase II promoter	Hs	biological process
transcription from RNA polymerase II promoter	Hs	biological process
mRNA processing	Hs	biological process
protein phosphorylation	Hs	biological process
defense response	Hs	biological process
cellular response to DNA damage stimulus	Hs	biological process
female meiotic nuclear division	Hs	biological process
spermatogenesis	Hs	biological process
response to nutrient	Hs	biological process
positive regulation of cell proliferation	Hs	biological process
negative regulation of cell proliferation	Hs	biological process
mRNA transcription	Hs	biological process
response to heat	Hs	biological process
positive regulation of gene expression	Hs	biological process
negative regulation of gene expression	Hs	biological process
negative regulation of cardiac muscle cell apoptotic process	Hs	biological process
response to organic cyclic compound	Hs	biological process
response to activity	Hs	biological process
PML body	Hs	cellular component
protein kinase binding	Hs	molecular function
heat shock protein binding	Hs	molecular function
chromatin DNA binding	Hs	molecular function
response to estradiol	Hs	biological process
response to lipopolysaccharide	Hs	biological process
cellular response to heat	Hs	biological process
cellular response to unfolded protein	Hs	biological process
positive regulation of multicellular organism growth	Hs	biological process
positive regulation of tyrosine phosphorylation of STAT protein	Hs	biological process
identical protein binding	Hs	molecular function
protein homodimerization activity	Hs	molecular function
response to amino acid	Hs	biological process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Hs	biological process
sequence-specific DNA binding	Hs	molecular function
protein self-association	Hs	molecular function
pronucleus	Hs	cellular component
positive regulation of mitotic cell cycle	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
protein heterodimerization activity	Hs	molecular function
perinuclear region of cytoplasm	Hs	cellular component
mRNA transport	Hs	biological process
protein homooligomerization	Hs	biological process
Hsp90 protein binding	Hs	molecular function
translation elongation factor binding	Hs	molecular function
protein homotrimerization	Hs	biological process
cellular response to hydrogen peroxide	Hs	biological process
cellular response to lipopolysaccharide	Hs	biological process
cellular response to amino acid stimulus	Hs	biological process
cellular response to cadmium ion	Hs	biological process
cellular response to estradiol stimulus	Hs	biological process
cellular response to organic cyclic compound	Hs	biological process
cellular response to gamma radiation	Hs	biological process
nuclear stress granule	Hs	cellular component
mitotic spindle pole	Hs	cellular component
STAT family protein binding	Hs	molecular function
sequence-specific single stranded DNA binding	Hs	molecular function
positive regulation of mRNA polyadenylation	Hs	biological process
negative regulation of neuron death	Hs	biological process
response to peptide	Hs	biological process
promoter-specific chromatin binding	Hs	molecular function
ribonucleoprotein complex	Hs	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
chromosome, centromeric region	Hs	cellular component	204	7.74e-60
kinetochore	Hs	cellular component	204	7.74e-60
condensed chromosome kinetochore	Hs	cellular component	204	7.74e-60
euchromatin	Hs	cellular component	204	7.74e-60
heterochromatin	Hs	cellular component	204	7.74e-60
spindle pole	Hs	cellular component	204	7.74e-60
RNA polymerase II regulatory region sequence-specific DNA binding	Hs	molecular function	192	3.43e-55
RNA polymerase II core promoter proximal region sequence-specific DNA binding	Hs	molecular function	204	7.74e-60
RNA polymerase II transcription factor activity, sequence-specific DNA binding	Hs	molecular function	204	7.74e-60
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	Hs	molecular function	204	7.74e-60
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	Hs	molecular function	204	7.74e-60
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	Hs	molecular function	192	3.43e-55
DNA binding	Hs	molecular function	204	7.74e-60
chromatin binding	Hs	molecular function	204	7.74e-60
transcription factor activity, sequence-specific DNA binding	Hs	molecular function	204	7.74e-60
transcription coactivator activity	Hs	molecular function	192	3.43e-55
transcription corepressor activity	Hs	molecular function	180	5.93e-51
protein binding	Hs	molecular function	204	7.74e-60
nucleus	Hs	cellular component	204	7.74e-60
nucleoplasm	Hs	cellular component	204	7.74e-60
chromosome	Hs	cellular component	204	7.74e-60
cytoplasm	Hs	cellular component	204	7.74e-60
centrosome	Hs	cellular component	204	7.74e-60
microtubule organizing center	Hs	cellular component	204	7.74e-60
cytosol	Hs	cellular component	204	7.74e-60
cytoskeleton	Hs	cellular component	204	7.74e-60
PML body	Hs	cellular component	204	7.74e-60
nuclear speck	Hs	cellular component	180	5.93e-51
protein kinase binding	Hs	molecular function	204	7.74e-60
heat shock protein binding	Hs	molecular function	204	7.74e-60
chromatin DNA binding	Hs	molecular function	204	7.74e-60
identical protein binding	Hs	molecular function	204	7.74e-60
protein homodimerization activity	Hs	molecular function	192	3.43e-55
sequence-specific DNA binding	Hs	molecular function	204	7.74e-60
protein self-association	Hs	molecular function	204	7.74e-60
pronucleus	Hs	cellular component	204	7.74e-60
protein heterodimerization activity	Hs	molecular function	204	7.74e-60
perinuclear region of cytoplasm	Hs	cellular component	204	7.74e-60
Hsp90 protein binding	Hs	molecular function	204	7.74e-60
translation elongation factor binding	Hs	molecular function	204	7.74e-60
nuclear stress granule	Hs	cellular component	204	7.74e-60
mitotic spindle pole	Hs	cellular component	204	7.74e-60
STAT family protein binding	Hs	molecular function	204	7.74e-60
sequence-specific single stranded DNA binding	Hs	molecular function	204	7.74e-60
promoter-specific chromatin binding	Hs	molecular function	204	7.74e-60
ribonucleoprotein complex	Hs	cellular component	204	7.74e-60

GO Term	Analysis	Type	e-value
transcription factor activity, sequence-specific DNA binding	SMART	molecular function	8.0E-46
nucleus	SMART	cellular component	8.0E-46
regulation of transcription, DNA-templated	SMART	biological process	8.0E-46
regulation of transcription from RNA polymerase II promoter	PANTHER	biological process	2.7E-68
sequence-specific DNA binding	SMART	molecular function	8.0E-46