IPR Term	Analysis	Definition
Frizzled/SFRP	PANTHER	Frizzled/secreted frizzled-related protein
TIMP-like_OB-fold	SUPERFAMILY	Tissue inhibitor of metalloproteinases-like, OB-fold
Frizzled_dom	Pfam	Frizzled domain
Frizzled_dom_sf	Gene3D	Frizzled cysteine-rich domain superfamily
Frizzled_dom	ProSiteProfiles	Frizzled domain
Frizzled_dom_sf	SUPERFAMILY	Frizzled cysteine-rich domain superfamily
SFRP-5	PANTHER	Secreted frizzled-related protein 5
Netrin_domain	ProSiteProfiles	Netrin domain
Frizzled_dom	SMART	Frizzled domain

GO Term	Annotation Origin	Type
G-protein coupled receptor activity	Orthology	molecular function
integrin binding	Blast	molecular function
protein binding	Orthology	molecular function
extracellular region	Orthology	cellular component
extracellular space	Orthology	cellular component
intracellular	Orthology	cellular component
cytosol	Orthology	cellular component
plasma membrane	Orthology	cellular component
proteolysis	Orthology	biological process
apoptotic process	Orthology	biological process
signal transduction	Orthology	biological process
G-protein coupled receptor signaling pathway	Orthology	biological process
cell-cell signaling	Orthology	biological process
multicellular organism development	Orthology	biological process
visual perception	Orthology	biological process
enzyme activator activity	Blast	molecular function
positive regulation of cell proliferation	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
cell surface	Orthology	cellular component
negative regulation of gene expression	Orthology	biological process
integral component of membrane	Orthology	cellular component
regulation of Wnt signaling pathway	Orthology	biological process
cell differentiation	Orthology	biological process
positive regulation of Wnt signaling pathway	Orthology	biological process
negative regulation of Wnt signaling pathway	Orthology	biological process
identical protein binding	Orthology	molecular function
positive regulation of apoptotic process	Orthology	biological process
negative regulation of apoptotic process	Orthology	biological process
positive regulation of GTPase activity	Orthology	biological process
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription, DNA-templated	Orthology	biological process
extracellular exosome	Orthology	cellular component
negative regulation of canonical Wnt signaling pathway	Orthology	biological process
positive regulation of canonical Wnt signaling pathway	Orthology	biological process
animal organ development	Orthology	biological process
anatomical structure formation involved in morphogenesis	Orthology	biological process
nervous system development	Orthology	biological process
cell adhesion	Orthology	biological process
immune system process	Orthology	biological process
endopeptidase activity	Orthology	molecular function
receptor binding	Orthology	molecular function
cellular process	Orthology	biological process
binding	Orthology	molecular function
anion binding	Orthology	molecular function
carbohydrate derivative binding	Orthology	molecular function
reproductive process	Orthology	biological process
cell communication	Orthology	biological process
cellular response to stress	Orthology	biological process
neuron projection development	Orthology	biological process
response to organic substance	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
cellular component organization	Orthology	biological process
cell migration	Orthology	biological process
regulation of transcription from RNA polymerase II promoter	Orthology	biological process
cellular response to organic substance	Orthology	biological process
regulation of signal transduction	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
extracellular region part	Orthology	cellular component
developmental process	Orthology	biological process
transmembrane signaling receptor activity	Orthology	molecular function
regulation of molecular function	Orthology	biological process
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
regulation of catalytic activity	Orthology	biological process
intracellular signal transduction	Orthology	biological process
protein serine/threonine kinase activity	Orthology	molecular function
angiogenesis	Orthology	biological process
positive regulation of signal transduction	Orthology	biological process
protein transport	Orthology	biological process
system development	Orthology	biological process
protein phosphorylation	Orthology	biological process
organelle organization	Orthology	biological process
response to lipid	Orthology	biological process
response to hypoxia	Orthology	biological process
neuron differentiation	Orthology	biological process
molecular function regulator	Blast	molecular function
signaling receptor activity	Blast	molecular function
positive regulation of hydrolase activity	Blast	biological process
enzyme binding	Blast	molecular function

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
osteoblast differentiation	Hs	biological process
ureteric bud development	Hs	biological process
somitogenesis	Hs	biological process
neural tube closure	Hs	biological process
positive regulation of cell-matrix adhesion	Hs	biological process
hematopoietic progenitor cell differentiation	Hs	biological process
cysteine-type endopeptidase activity	Hs	molecular function
G-protein coupled receptor activity	Hs	molecular function
frizzled binding	Hs	molecular function
protein binding	Hs	molecular function
extracellular region	Hs	cellular component
proteinaceous extracellular matrix	Hs	cellular component
extracellular space	Hs	cellular component
intracellular	Hs	cellular component
cytosol	Hs	cellular component
plasma membrane	Hs	cellular component
proteolysis	Hs	biological process
apoptotic process	Hs	biological process
establishment or maintenance of cell polarity	Hs	biological process
signal transduction	Hs	biological process
G-protein coupled receptor signaling pathway	Hs	biological process
multicellular organism development	Hs	biological process
visual perception	Hs	biological process
drug binding	Hs	molecular function
heparin binding	Hs	molecular function
positive regulation of cell proliferation	Hs	biological process
negative regulation of cell proliferation	Hs	biological process
male gonad development	Hs	biological process
female gonad development	Hs	biological process
cellular response to starvation	Hs	biological process
anatomical structure morphogenesis	Hs	biological process
dorsal/ventral axis specification	Hs	biological process
anterior/posterior pattern specification	Hs	biological process
cell surface	Hs	cellular component
regulation of cell cycle process	Hs	biological process
negative regulation of gene expression	Hs	biological process
negative regulation of epithelial to mesenchymal transition	Hs	biological process
regulation of neuron projection development	Hs	biological process
response to organic cyclic compound	Hs	biological process
integral component of membrane	Hs	cellular component
Wnt signaling pathway	Hs	biological process
Wnt-protein binding	Hs	molecular function
neural tube development	Hs	biological process
hemopoiesis	Hs	biological process
regulation of Wnt signaling pathway	Hs	biological process
cell differentiation	Hs	biological process
positive regulation of Wnt signaling pathway	Hs	biological process
negative regulation of Wnt signaling pathway	Hs	biological process
negative regulation of ossification	Hs	biological process
positive regulation of cell growth	Hs	biological process
negative regulation of cell growth	Hs	biological process
negative regulation of cell migration	Hs	biological process
regulation of BMP signaling pathway	Hs	biological process
negative regulation of BMP signaling pathway	Hs	biological process
extracellular matrix	Hs	cellular component
negative regulation of osteoblast proliferation	Hs	biological process
somatic stem cell population maintenance	Hs	biological process
negative regulation of catenin import into nucleus	Hs	biological process
non-canonical Wnt signaling pathway	Hs	biological process
response to drug	Hs	biological process
identical protein binding	Hs	molecular function
Wnt-activated receptor activity	Hs	molecular function
positive regulation of apoptotic process	Hs	biological process
negative regulation of apoptotic process	Hs	biological process
negative regulation of sequence-specific DNA binding transcription factor activity	Hs	biological process
negative regulation of JUN kinase activity	Hs	biological process
positive regulation of GTPase activity	Hs	biological process
positive regulation of fat cell differentiation	Hs	biological process
negative regulation of osteoblast differentiation	Hs	biological process
regulation of angiogenesis	Hs	biological process
positive regulation of smoothened signaling pathway	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription, DNA-templated	Hs	biological process
development of primary male sexual characteristics	Hs	biological process
negative regulation of insulin secretion	Hs	biological process
digestive tract morphogenesis	Hs	biological process
positive regulation of epithelial cell proliferation	Hs	biological process
negative regulation of epithelial cell proliferation	Hs	biological process
negative regulation of peptidyl-tyrosine phosphorylation	Hs	biological process
positive regulation of stress fiber assembly	Hs	biological process
positive regulation of focal adhesion assembly	Hs	biological process
negative regulation of protein kinase B signaling	Hs	biological process
canonical Wnt signaling pathway	Hs	biological process
Wnt signaling pathway, planar cell polarity pathway	Hs	biological process
hematopoietic stem cell differentiation	Hs	biological process
extracellular exosome	Hs	cellular component
cellular response to vitamin D	Hs	biological process
cellular response to interleukin-1	Hs	biological process
cellular response to tumor necrosis factor	Hs	biological process
cellular response to prostaglandin E stimulus	Hs	biological process
cellular response to estrogen stimulus	Hs	biological process
cellular response to estradiol stimulus	Hs	biological process
cellular response to hypoxia	Hs	biological process
cellular response to X-ray	Hs	biological process
dopaminergic neuron differentiation	Hs	biological process
cellular response to transforming growth factor beta stimulus	Hs	biological process
negative regulation of canonical Wnt signaling pathway	Hs	biological process
regulation of establishment of planar polarity	Hs	biological process
planar cell polarity pathway involved in neural tube closure	Hs	biological process
Wnt signaling pathway involved in somitogenesis	Hs	biological process
positive regulation of canonical Wnt signaling pathway	Hs	biological process
positive regulation of non-canonical Wnt signaling pathway	Hs	biological process
negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	Hs	biological process
positive regulation of extrinsic apoptotic signaling pathway	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
fibronectin binding	Hs	molecular function	170	1.00e-50
cysteine-type endopeptidase activity	Hs	molecular function	184	6.83e-56
G-protein coupled receptor activity	Hs	molecular function	184	6.83e-56
frizzled binding	Hs	molecular function	184	6.83e-56
integrin binding	Hs	molecular function	170	1.00e-50
protein binding	Hs	molecular function	184	6.83e-56
extracellular region	Hs	cellular component	184	6.83e-56
proteinaceous extracellular matrix	Hs	cellular component	184	6.83e-56
extracellular space	Hs	cellular component	184	6.83e-56
intracellular	Hs	cellular component	184	6.83e-56
cytosol	Hs	cellular component	184	6.83e-56
plasma membrane	Hs	cellular component	184	6.83e-56
enzyme activator activity	Hs	molecular function	170	1.00e-50
drug binding	Hs	molecular function	184	6.83e-56
heparin binding	Hs	molecular function	184	6.83e-56
cell surface	Hs	cellular component	184	6.83e-56
integral component of membrane	Hs	cellular component	184	6.83e-56
Wnt-protein binding	Hs	molecular function	184	6.83e-56
extracellular matrix	Hs	cellular component	184	6.83e-56
identical protein binding	Hs	molecular function	184	6.83e-56
Wnt-activated receptor activity	Hs	molecular function	184	6.83e-56
receptor ligand activity	Hs	molecular function	170	1.00e-50
endopeptidase activator activity	Hs	molecular function	170	1.00e-50
extracellular exosome	Hs	cellular component	184	6.83e-56

GO Term	Analysis	Type	e-value
protein binding	SMART	molecular function	3.7E-42
regulation of Wnt signaling pathway	PANTHER	biological process	2.6E-65
regulation of BMP signaling pathway	PANTHER	biological process	2.6E-65