IPR Term	Analysis	Definition
Proteasome_bsu_CS	ProSitePatterns	Proteasome beta-type subunit, conserved site
Ntn_hydrolases_N	Gene3D	Nucleophile aminohydrolases, N-terminal
Proteasome_suB-type	ProSiteProfiles	Proteasome B-type subunit
Proteasome_sua/b	Pfam	Proteasome, subunit alpha/beta
Ntn_hydrolases_N	SUPERFAMILY	Nucleophile aminohydrolases, N-terminal
Proteasome_beta_3	CDD	Proteasome beta 3 subunit
Proteasome_beta_3	PANTHER	Proteasome beta 3 subunit

GO Term	Annotation Origin	Type
protein polyubiquitination	Orthology	biological process
endopeptidase activity	Orthology	molecular function
protein binding	Orthology	molecular function
extracellular region	Blast	cellular component
nucleus	Orthology	cellular component
nucleoplasm	Orthology	cellular component
cytoplasm	Orthology	cellular component
cytosol	Orthology	cellular component
proteolysis	Orthology	biological process
peptidase activity	Orthology	molecular function
hydrolase activity	Orthology	molecular function
transmembrane transport	Orthology	biological process
extracellular exosome	Orthology	cellular component
negative regulation of canonical Wnt signaling pathway	Orthology	biological process
positive regulation of canonical Wnt signaling pathway	Orthology	biological process
intracellular signal transduction	Orthology	biological process
protein phosphorylation	Orthology	biological process
intracellular part	Orthology	cellular component
macromolecular complex	Orthology	cellular component
G2/M transition of mitotic cell cycle	Orthology	biological process
peptidase activity, acting on L-amino acid peptides	Orthology	molecular function
cytokine-mediated signaling pathway	Orthology	biological process
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
cell surface receptor signaling pathway	Orthology	biological process
immune response	Orthology	biological process
mRNA catabolic process	Orthology	biological process
cellular protein modification process	Orthology	biological process
cell-cell signaling	Orthology	biological process
anatomical structure morphogenesis	Orthology	biological process
animal organ development	Orthology	biological process
immune system process	Orthology	biological process
cell differentiation	Orthology	biological process
intracellular organelle part	Blast	cellular component
cytoplasmic vesicle	Blast	cellular component
endomembrane system	Blast	cellular component
intracellular organelle lumen	Blast	cellular component

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
MAPK cascade	Hs	biological process
protein polyubiquitination	Hs	biological process
proteasome complex	Hs	cellular component
endopeptidase activity	Hs	molecular function
threonine-type endopeptidase activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
nucleoplasm	Hs	cellular component
cytoplasm	Hs	cellular component
cytosol	Hs	cellular component
proteasome core complex	Hs	cellular component
proteolysis	Hs	biological process
peptidase activity	Hs	molecular function
negative regulation of G2/M transition of mitotic cell cycle	Hs	biological process
viral process	Hs	biological process
protein deubiquitination	Hs	biological process
hydrolase activity	Hs	molecular function
proteasome core complex, beta-subunit complex	Hs	cellular component
anaphase-promoting complex-dependent catabolic process	Hs	biological process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Hs	biological process
tumor necrosis factor-mediated signaling pathway	Hs	biological process
NIK/NF-kappaB signaling	Hs	biological process
Fc-epsilon receptor signaling pathway	Hs	biological process
proteasome-mediated ubiquitin-dependent protein catabolic process	Hs	biological process
regulation of mRNA stability	Hs	biological process
post-translational protein modification	Hs	biological process
T cell receptor signaling pathway	Hs	biological process
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Hs	biological process
proteolysis involved in cellular protein catabolic process	Hs	biological process
transmembrane transport	Hs	biological process
Wnt signaling pathway, planar cell polarity pathway	Hs	biological process
extracellular exosome	Hs	cellular component
interleukin-1-mediated signaling pathway	Hs	biological process
negative regulation of canonical Wnt signaling pathway	Hs	biological process
positive regulation of canonical Wnt signaling pathway	Hs	biological process
regulation of hematopoietic stem cell differentiation	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
proteasome complex	Hs	cellular component	317	9.88e-112
endopeptidase activity	Hs	molecular function	317	9.88e-112
threonine-type endopeptidase activity	Hs	molecular function	317	9.88e-112
protein binding	Hs	molecular function	317	9.88e-112
extracellular region	Hs	cellular component	77.8	1.63e-17
nucleus	Hs	cellular component	317	9.88e-112
nucleoplasm	Hs	cellular component	317	9.88e-112
cytoplasm	Hs	cellular component	317	9.88e-112
cytosol	Hs	cellular component	317	9.88e-112
proteasome core complex	Hs	cellular component	317	9.88e-112
peptidase activity	Hs	molecular function	317	9.88e-112
hydrolase activity	Hs	molecular function	317	9.88e-112
proteasome core complex, beta-subunit complex	Hs	cellular component	317	9.88e-112
secretory granule lumen	Hs	cellular component	77.8	1.63e-17
extracellular exosome	Hs	cellular component	317	9.88e-112
ficolin-1-rich granule lumen	Hs	cellular component	77.8	1.63e-17

GO Term	Analysis	Type	e-value
endopeptidase activity	ProSitePatterns	molecular function
threonine-type endopeptidase activity	Pfam	molecular function	7.4E-42
proteasome core complex	Pfam	cellular component	7.4E-42
proteasome core complex, beta-subunit complex	CDD	cellular component	9.54988E-127
proteasome-mediated ubiquitin-dependent protein catabolic process	CDD	biological process	9.54988E-127
proteolysis involved in cellular protein catabolic process	Pfam	biological process	7.4E-42