IPR Term	Analysis	Definition
RNase_CAF1	Pfam	Ribonuclease CAF1
RNaseH_sf	Gene3D	Ribonuclease H superfamily
RNaseH-like_sf	SUPERFAMILY	Ribonuclease H-like superfamily

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
nucleic acid binding	Orthology	molecular function
transcription factor activity, sequence-specific DNA binding	Orthology	molecular function
RNA binding	Orthology	molecular function
signal transducer activity	Orthology	molecular function
protein binding	Orthology	molecular function
intracellular	Orthology	cellular component
nucleus	Orthology	cellular component
cytoplasm	Orthology	cellular component
cytosol	Orthology	cellular component
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
signal transduction	Orthology	biological process
transcription factor binding	Orthology	molecular function
positive regulation of cell proliferation	Orthology	biological process
negative regulation of cell proliferation	Orthology	biological process
negative regulation of gene expression	Orthology	biological process
membrane	Orthology	cellular component
nuclear body	Orthology	cellular component
nuclear speck	Orthology	cellular component
hydrolase activity	Orthology	molecular function
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
metal ion binding	Orthology	molecular function
RNA metabolic process	Orthology	biological process
nuclear-transcribed mRNA catabolic process	Orthology	biological process
cytoplasmic part	Orthology	cellular component
intracellular non-membrane-bounded organelle	Orthology	cellular component
macromolecular complex	Orthology	cellular component
organic substance metabolic process	Orthology	biological process
regulation of gene expression	Orthology	biological process
intracellular part	Orthology	cellular component
cellular process	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
regulation of signal transduction	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
protein phosphorylation	Orthology	biological process
immune system process	Orthology	biological process
defense response	Orthology	biological process
cytokine-mediated signaling pathway	Orthology	biological process
negative regulation of signal transduction	Orthology	biological process
innate immune response	Orthology	biological process
mRNA catabolic process	Orthology	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
3'-5'-exoribonuclease activity	Hs	molecular function
nuclear-transcribed mRNA poly(A) tail shortening	Hs	biological process
deadenylation-dependent decapping of nuclear-transcribed mRNA	Hs	biological process
P-body	Hs	cellular component
transcriptional repressor activity, RNA polymerase II transcription factor binding	Hs	molecular function
nucleic acid binding	Hs	molecular function
transcription factor activity, sequence-specific DNA binding	Hs	molecular function
RNA binding	Hs	molecular function
nuclease activity	Hs	molecular function
exonuclease activity	Hs	molecular function
exoribonuclease activity	Hs	molecular function
poly(A)-specific ribonuclease activity	Hs	molecular function
signal transducer activity	Hs	molecular function
protein binding	Hs	molecular function
intracellular	Hs	cellular component
nucleus	Hs	cellular component
cytoplasm	Hs	cellular component
cytosol	Hs	cellular component
carbohydrate metabolic process	Hs	biological process
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
regulation of translation	Hs	biological process
signal transduction	Hs	biological process
transcription factor binding	Hs	molecular function
positive regulation of cell proliferation	Hs	biological process
negative regulation of cell proliferation	Hs	biological process
negative regulation of gene expression	Hs	biological process
membrane	Hs	cellular component
nuclear body	Hs	cellular component
nuclear speck	Hs	cellular component
hydrolase activity	Hs	molecular function
CCR4-NOT complex	Hs	cellular component
CCR4-NOT core complex	Hs	cellular component
gene silencing by RNA	Hs	biological process
cytoplasmic mRNA processing body assembly	Hs	biological process
gene silencing by miRNA	Hs	biological process
regulation of tyrosine phosphorylation of STAT protein	Hs	biological process
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
metal ion binding	Hs	molecular function
defense response to virus	Hs	biological process
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	Hs	biological process
negative regulation of type I interferon-mediated signaling pathway	Hs	biological process
positive regulation of mRNA catabolic process	Hs	biological process
host cell PML body	Hs	cellular component
nucleic acid phosphodiester bond hydrolysis	Hs	biological process
RNA phosphodiester bond hydrolysis, exonucleolytic	Hs	biological process
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Hs	biological process

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
3'-5'-exoribonuclease activity	Hs	molecular function	427	1.46e-152
P-body	Hs	cellular component	427	1.46e-152
transcriptional repressor activity, RNA polymerase II transcription factor binding	Hs	molecular function	427	1.46e-152
nucleic acid binding	Hs	molecular function	427	1.46e-152
transcription factor activity, sequence-specific DNA binding	Hs	molecular function	427	1.46e-152
RNA binding	Hs	molecular function	427	1.46e-152
nuclease activity	Hs	molecular function	427	1.46e-152
exonuclease activity	Hs	molecular function	427	1.46e-152
exoribonuclease activity	Hs	molecular function	427	1.46e-152
poly(A)-specific ribonuclease activity	Hs	molecular function	427	1.46e-152
signal transducer activity	Hs	molecular function	427	1.46e-152
protein binding	Hs	molecular function	427	1.46e-152
intracellular	Hs	cellular component	397	2.14e-140
nucleus	Hs	cellular component	427	1.46e-152
cytoplasm	Hs	cellular component	427	1.46e-152
cytosol	Hs	cellular component	427	1.46e-152
transcription factor binding	Hs	molecular function	427	1.46e-152
membrane	Hs	cellular component	427	1.46e-152
nuclear body	Hs	cellular component	427	1.46e-152
nuclear speck	Hs	cellular component	427	1.46e-152
hydrolase activity	Hs	molecular function	427	1.46e-152
CCR4-NOT complex	Hs	cellular component	427	1.46e-152
CCR4-NOT core complex	Hs	cellular component	427	1.46e-152
metal ion binding	Hs	molecular function	427	1.46e-152
host cell PML body	Hs	cellular component	427	1.46e-152

GO Term	Analysis	Type	e-value
nucleic acid binding	Gene3D	molecular function	2.7E-119
poly(A)-specific ribonuclease activity	PANTHER	molecular function	3.6E-165