Gene Card
Best human hits
HACE1; HUWE1; UBR5
Species
Unique Gene ID
Phfumi.g00002866
Gene Model ID
Phfumi.CG.MTP2014.S858.g02866
Location
S858:20710..28632
Transcript Models and Sequences
n/a
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The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
PABP_HYD | ProSiteProfiles | Polyadenylate-binding protein/Hyperplastic disc protein |
PABP-dom | SUPERFAMILY | PABC (PABP) domain |
HECT_dom | Pfam | HECT domain |
PABP_HYD | SMART | Polyadenylate-binding protein/Hyperplastic disc protein |
HECT_dom | SMART | HECT domain |
HECT_dom | ProSiteProfiles | HECT domain |
PABP_HYD | Pfam | Polyadenylate-binding protein/Hyperplastic disc protein |
Hect_E3_ubiquitin_ligase | SUPERFAMILY | HECT, E3 ligase catalytic domain |
GO Term | Annotation Origin | Type |
---|---|---|
Golgi membrane | Blast | cellular component |
protein polyubiquitination | Orthology | biological process |
DNA binding | Blast | molecular function |
RNA binding | Orthology | molecular function |
ubiquitin-protein transferase activity | Orthology | molecular function |
binding | Blast | molecular function |
protein binding | Orthology | molecular function |
extracellular region | Blast | cellular component |
nucleus | Orthology | cellular component |
nucleoplasm | Orthology | cellular component |
cytoplasm | Blast | cellular component |
endoplasmic reticulum | Blast | cellular component |
Golgi apparatus | Blast | cellular component |
cytosol | Orthology | cellular component |
DNA repair | Orthology | biological process |
cellular response to DNA damage stimulus | Orthology | biological process |
zinc ion binding | Orthology | molecular function |
cell proliferation | Orthology | biological process |
positive regulation of gene expression | Orthology | biological process |
membrane | Orthology | cellular component |
protein ubiquitination | Orthology | biological process |
nuclear body | Blast | cellular component |
transferase activity | Orthology | molecular function |
macromolecular complex | Orthology | cellular component |
metal ion binding | Orthology | molecular function |
perinuclear region of cytoplasm | Orthology | cellular component |
extracellular exosome | Blast | cellular component |
positive regulation of canonical Wnt signaling pathway | Orthology | biological process |
proteolysis | Orthology | biological process |
signal transduction | Orthology | biological process |
response to lipid | Orthology | biological process |
cellular response to organic substance | Orthology | biological process |
organelle organization | Orthology | biological process |
enzyme binding | Blast | molecular function |
intracellular organelle part | Blast | cellular component |
cytoplasmic vesicle | Blast | cellular component |
endomembrane system | Blast | cellular component |
intracellular organelle lumen | Blast | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
protein polyubiquitination | Hs | biological process |
RNA binding | Hs | molecular function |
ubiquitin-protein transferase activity | Hs | molecular function |
protein binding | Hs | molecular function |
nucleus | Hs | cellular component |
nucleoplasm | Hs | cellular component |
cytosol | Hs | cellular component |
DNA repair | Hs | biological process |
ubiquitin-dependent protein catabolic process | Hs | biological process |
cellular response to DNA damage stimulus | Hs | biological process |
zinc ion binding | Hs | molecular function |
cell proliferation | Hs | biological process |
positive regulation of gene expression | Hs | biological process |
membrane | Hs | cellular component |
protein ubiquitination | Hs | biological process |
transferase activity | Hs | molecular function |
macromolecular complex | Hs | cellular component |
positive regulation of protein import into nucleus, translocation | Hs | biological process |
ubiquitin-ubiquitin ligase activity | Hs | molecular function |
ubiquitin binding | Hs | molecular function |
metal ion binding | Hs | molecular function |
perinuclear region of cytoplasm | Hs | cellular component |
progesterone receptor signaling pathway | Hs | biological process |
ubiquitin protein ligase activity | Hs | molecular function |
protein K48-linked ubiquitination | Hs | biological process |
positive regulation of canonical Wnt signaling pathway | Hs | biological process |
negative regulation of histone H2A K63-linked ubiquitination | Hs | biological process |
negative regulation of double-strand break repair | Hs | biological process |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
Golgi membrane | Hs | cellular component | 75.5 | 7.70e-14 |
DNA binding | Hs | molecular function | 78.2 | 1.71e-14 |
RNA binding | Hs | molecular function | 570 | 1.68e-178 |
ubiquitin-protein transferase activity | Hs | molecular function | 570 | 1.68e-178 |
binding | Hs | molecular function | 78.2 | 1.71e-14 |
protein binding | Hs | molecular function | 570 | 1.68e-178 |
extracellular region | Hs | cellular component | 78.2 | 1.71e-14 |
nucleus | Hs | cellular component | 570 | 1.68e-178 |
nucleoplasm | Hs | cellular component | 570 | 1.68e-178 |
cytoplasm | Hs | cellular component | 78.2 | 1.71e-14 |
endoplasmic reticulum | Hs | cellular component | 75.5 | 7.70e-14 |
Golgi apparatus | Hs | cellular component | 75.5 | 7.70e-14 |
cytosol | Hs | cellular component | 570 | 1.68e-178 |
zinc ion binding | Hs | molecular function | 570 | 1.68e-178 |
membrane | Hs | cellular component | 570 | 1.68e-178 |
nuclear body | Hs | cellular component | 75.5 | 7.70e-14 |
transferase activity | Hs | molecular function | 570 | 1.68e-178 |
Rab GTPase binding | Hs | molecular function | 75.5 | 7.70e-14 |
Golgi cisterna membrane | Hs | cellular component | 75.5 | 7.70e-14 |
macromolecular complex | Hs | cellular component | 570 | 1.68e-178 |
ubiquitin-ubiquitin ligase activity | Hs | molecular function | 570 | 1.68e-178 |
secretory granule lumen | Hs | cellular component | 78.2 | 1.71e-14 |
ubiquitin binding | Hs | molecular function | 570 | 1.68e-178 |
metal ion binding | Hs | molecular function | 570 | 1.68e-178 |
Rac GTPase binding | Hs | molecular function | 75.5 | 7.70e-14 |
perinuclear region of cytoplasm | Hs | cellular component | 570 | 1.68e-178 |
ubiquitin protein ligase activity | Hs | molecular function | 570 | 1.68e-178 |
extracellular exosome | Hs | cellular component | 78.2 | 1.71e-14 |
ficolin-1-rich granule lumen | Hs | cellular component | 78.2 | 1.71e-14 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
RNA binding | SMART | molecular function | 1.7E-20 |
ubiquitin-protein transferase activity | SUPERFAMILY | molecular function | 1.83E-36 |