Gene Card
Best human hits
SIRT3; SIRT6; SIRT7
Species
Unique Gene ID
Moocci.g00017690
Gene Model ID
Moocci.CG.ELv1_2.S487427.g17690
Location
S487427:76761..81797
Transcript Models and Sequences
n/a
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The 'History' button on the left side permits you to see the changes you have made and eventually to go back.
You can Press 'Shift' Key + Left Mouse Click on the leaf's node to access to a gene card in a new window.
You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.
Click here to see the tree inference method
InterPro
3 results
| IPR Term | Analysis | Definition |
|---|---|---|
| DHS-like_NAD/FAD-binding_dom | SUPERFAMILY | DHS-like NAD/FAD-binding domain superfamily |
| Ssirtuin_cat_dom | ProSiteProfiles | Sirtuin family, catalytic core domain |
| Sirtuin | Pfam | Sirtuin family |
| GO Term | Annotation Origin | Type |
|---|
GO (Orthology)
16 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
|---|---|---|
| negative regulation of transcription from RNA polymerase II promoter | Hs | biological process |
| chromatin binding | Hs | molecular function |
| protein binding | Hs | molecular function |
| nucleus | Hs | cellular component |
| nucleolus | Hs | cellular component |
| nucleolus organizer region | Hs | cellular component |
| cytoplasm | Hs | cellular component |
| chromatin organization | Hs | biological process |
| transcription, DNA-templated | Hs | biological process |
| regulation of transcription, DNA-templated | Hs | biological process |
| rRNA transcription | Hs | biological process |
| hydrolase activity | Hs | molecular function |
| metal ion binding | Hs | molecular function |
| NAD+ binding | Hs | molecular function |
| histone H3 deacetylation | Hs | biological process |
| NAD-dependent histone deacetylase activity (H3-K18 specific) | Hs | molecular function |
GO (Blast)
25 results
| GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
|---|---|---|---|---|
| chromatin binding | Hs | molecular function | 298 | 4.67e-98 |
| transcription corepressor activity | Hs | molecular function | 135 | 4.37e-36 |
| NAD+ ADP-ribosyltransferase activity | Hs | molecular function | 135 | 4.37e-36 |
| NAD(P)+-protein-arginine ADP-ribosyltransferase activity | Hs | molecular function | 135 | 4.37e-36 |
| protein binding | Hs | molecular function | 298 | 4.67e-98 |
| nucleus | Hs | cellular component | 298 | 4.67e-98 |
| nucleoplasm | Hs | cellular component | 135 | 4.37e-36 |
| nuclear telomeric heterochromatin | Hs | cellular component | 135 | 4.37e-36 |
| nucleolus | Hs | cellular component | 298 | 4.67e-98 |
| nucleolus organizer region | Hs | cellular component | 298 | 4.67e-98 |
| cytoplasm | Hs | cellular component | 298 | 4.67e-98 |
| mitochondrion | Hs | cellular component | 68.6 | 1.57e-12 |
| mitochondrial matrix | Hs | cellular component | 68.6 | 1.57e-12 |
| zinc ion binding | Hs | molecular function | 135 | 4.37e-36 |
| hydrolase activity | Hs | molecular function | 298 | 4.67e-98 |
| NAD-dependent histone deacetylase activity | Hs | molecular function | 135 | 4.37e-36 |
| enzyme binding | Hs | molecular function | 68.6 | 1.57e-12 |
| macromolecular complex | Hs | cellular component | 68.6 | 1.57e-12 |
| protein deacetylase activity | Hs | molecular function | 135 | 4.37e-36 |
| NAD-dependent protein deacetylase activity | Hs | molecular function | 135 | 4.37e-36 |
| sequence-specific DNA binding | Hs | molecular function | 68.6 | 1.57e-12 |
| metal ion binding | Hs | molecular function | 298 | 4.67e-98 |
| NAD-dependent histone deacetylase activity (H3-K9 specific) | Hs | molecular function | 135 | 4.37e-36 |
| NAD+ binding | Hs | molecular function | 298 | 4.67e-98 |
| NAD-dependent histone deacetylase activity (H3-K18 specific) | Hs | molecular function | 298 | 4.67e-98 |
GO (InterProScan)
1 result
| GO Term | Analysis | Type | e-value |
|---|---|---|---|
| NAD+ binding | Pfam | molecular function | 3.5E-15 |
