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GENE CARD

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Gene Card

Best human hits

EZH1; EZH2; SETD2

Species

H.roretzi

Unique Gene ID

Harore.g00015552

Gene Model ID

Harore.CG.MTP2014.S59.g15552

Location

S59:114216..116475

Transcript Models and Sequences

  Harore.CG.MTP2014.S59.g15552.01.t

External Database Gene Card

External database links

No result

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WashU Genome Browser

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Genomicus Synteny Browser

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Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

6 results

IPR Term Analysis Definition
Tesmin/TSO1-like_CXC SMART Tesmin/TSO1-like CXC domain
EZH1 PANTHER Histone-lysine N-methyltransferase EZH1
SET_dom ProSiteProfiles SET domain
SET_dom Pfam SET domain
CXC_dom ProSiteProfiles CXC domain
SET_dom SMART SET domain

GOSlim

56 results

GO Term Annotation Origin Type
negative regulation of transcription from RNA polymerase II promoter Orthology biological process
RNA polymerase II core promoter proximal region sequence-specific DNA binding Orthology molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Orthology molecular function
DNA binding Orthology molecular function
chromatin binding Orthology molecular function
RNA binding Orthology molecular function
protein binding Orthology molecular function
nucleus Orthology cellular component
nucleoplasm Orthology cellular component
cytoplasm Orthology cellular component
transcription, DNA-templated Orthology biological process
regulation of transcription, DNA-templated Orthology biological process
regulation of transcription from RNA polymerase II promoter Orthology biological process
multicellular organism development Orthology biological process
anatomical structure morphogenesis Orthology biological process
regulation of gene expression Orthology biological process
negative regulation of gene expression Orthology biological process
transferase activity Orthology molecular function
cell differentiation Orthology biological process
regulation of cell proliferation Orthology biological process
positive regulation of GTPase activity Orthology biological process
sequence-specific DNA binding Orthology molecular function
transcription regulatory region DNA binding Orthology molecular function
negative regulation of transcription, DNA-templated Orthology biological process
positive regulation of transcription from RNA polymerase II promoter Orthology biological process
metal ion binding Blast molecular function
intracellular non-membrane-bounded organelle Orthology cellular component
nuclear lumen Orthology cellular component
RNA polymerase II regulatory region sequence-specific DNA binding Orthology molecular function
regulation of cellular metabolic process Orthology biological process
protein phosphorylation Orthology biological process
DNA metabolic process Orthology biological process
organelle organization Orthology biological process
metabolic process Orthology biological process
animal organ development Orthology biological process
cell development Orthology biological process
generation of neurons Orthology biological process
cellular protein modification process Orthology biological process
brain development Orthology biological process
response to lipid Orthology biological process
nucleoplasm part Orthology cellular component
macromolecular complex Orthology cellular component
macromolecular complex binding Orthology molecular function
positive regulation of catalytic activity Orthology biological process
intracellular signal transduction Orthology biological process
protein serine/threonine kinase activity Orthology molecular function
positive regulation of signal transduction Orthology biological process
regulation of molecular function Orthology biological process
transcription factor activity, sequence-specific DNA binding Orthology molecular function
negative regulation of signal transduction Orthology biological process
cellular response to stress Orthology biological process
response to oxidative stress Orthology biological process
protein localization to organelle Orthology biological process
neuron projection development Orthology biological process
G1/S transition of mitotic cell cycle Orthology biological process
tubulin binding Blast molecular function

GO (Orthology)

64 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
negative regulation of transcription from RNA polymerase II promoter Hs biological process
nuclear chromatin Hs cellular component
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function
RNA polymerase II core promoter sequence-specific DNA binding Hs molecular function
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function
core promoter binding Hs molecular function
regulation of protein phosphorylation Hs biological process
DNA binding Hs molecular function
chromatin binding Hs molecular function
RNA binding Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
nucleoplasm Hs cellular component
cytoplasm Hs cellular component
DNA methylation Hs biological process
chromatin organization Hs biological process
transcription, DNA-templated Hs biological process
regulation of transcription, DNA-templated Hs biological process
regulation of transcription from RNA polymerase II promoter Hs biological process
methyltransferase activity Hs molecular function
anatomical structure morphogenesis Hs biological process
regulation of gene expression Hs biological process
negative regulation of gene expression Hs biological process
positive regulation of epithelial to mesenchymal transition Hs biological process
regulation of gliogenesis Hs biological process
protein-lysine N-methyltransferase activity Hs molecular function
histone methylation Hs biological process
transferase activity Hs molecular function
histone-lysine N-methyltransferase activity Hs molecular function
cerebellar cortex development Hs biological process
chromatin DNA binding Hs molecular function
methylation Hs biological process
response to estradiol Hs biological process
negative regulation of transcription elongation from RNA polymerase II promoter Hs biological process
histone lysine methylation Hs biological process
ESC/E(Z) complex Hs cellular component
histone methyltransferase activity Hs molecular function
regulation of cell proliferation Hs biological process
regulation of circadian rhythm Hs biological process
ribonucleoprotein complex binding Hs molecular function
positive regulation of MAP kinase activity Hs biological process
negative regulation of sequence-specific DNA binding transcription factor activity Hs biological process
positive regulation of GTPase activity Hs biological process
sequence-specific DNA binding Hs molecular function
transcription regulatory region DNA binding Hs molecular function
pronucleus Hs cellular component
negative regulation of epidermal cell differentiation Hs biological process
negative regulation of gene expression, epigenetic Hs biological process
negative regulation of transcription, DNA-templated Hs biological process
positive regulation of transcription from RNA polymerase II promoter Hs biological process
histone methyltransferase activity (H3-K27 specific) Hs molecular function
negative regulation of retinoic acid receptor signaling pathway Hs biological process
rhythmic process Hs biological process
regulation of neurogenesis Hs biological process
cellular response to hydrogen peroxide Hs biological process
G1 to G0 transition Hs biological process
histone H3-K27 methylation Hs biological process
primary miRNA binding Hs molecular function
protein localization to chromatin Hs biological process
positive regulation of protein serine/threonine kinase activity Hs biological process
histone H3-K27 trimethylation Hs biological process
positive regulation of dendrite development Hs biological process
promoter-specific chromatin binding Hs molecular function
negative regulation of G1/S transition of mitotic cell cycle Hs biological process

GO (Blast)

30 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
nuclear chromatin Hs cellular component 801 0.0
RNA polymerase II core promoter proximal region sequence-specific DNA binding Hs molecular function 801 0.0
RNA polymerase II core promoter sequence-specific DNA binding Hs molecular function 801 0.0
RNA polymerase II transcription factor activity, sequence-specific DNA binding Hs molecular function 801 0.0
core promoter binding Hs molecular function 801 0.0
DNA binding Hs molecular function 801 0.0
chromatin binding Hs molecular function 801 0.0
RNA binding Hs molecular function 801 0.0
protein binding Hs molecular function 801 0.0
nucleus Hs cellular component 801 0.0
nucleoplasm Hs cellular component 801 0.0
chromosome Hs cellular component 104 8.97e-23
cytoplasm Hs cellular component 801 0.0
methyltransferase activity Hs molecular function 801 0.0
protein-lysine N-methyltransferase activity Hs molecular function 801 0.0
transferase activity Hs molecular function 801 0.0
histone-lysine N-methyltransferase activity Hs molecular function 801 0.0
chromatin DNA binding Hs molecular function 801 0.0
ESC/E(Z) complex Hs cellular component 801 0.0
histone methyltransferase activity Hs molecular function 801 0.0
alpha-tubulin binding Hs molecular function 104 8.97e-23
ribonucleoprotein complex binding Hs molecular function 801 0.0
sequence-specific DNA binding Hs molecular function 801 0.0
transcription regulatory region DNA binding Hs molecular function 801 0.0
pronucleus Hs cellular component 801 0.0
metal ion binding Hs molecular function 104 8.97e-23
histone methyltransferase activity (H3-K36 specific) Hs molecular function 104 8.97e-23
histone methyltransferase activity (H3-K27 specific) Hs molecular function 801 0.0
primary miRNA binding Hs molecular function 801 0.0
promoter-specific chromatin binding Hs molecular function 801 0.0

GO (InterProScan)

3 results

GO Term Analysis Type e-value
protein binding SMART molecular function 1.3E-32
histone-lysine N-methyltransferase activity PANTHER molecular function 1.6E-276
histone H3-K27 methylation PANTHER biological process 1.6E-276

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