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GENE CARD

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Gene Card

Best human hits

MFN1; MFN2

Species

H.roretzi

Unique Gene ID

Harore.g00001422

Gene Model ID

Harore.CG.MTP2014.S110.g01422

Location

S110:199321..204421

External Database Gene Card

External database links

No result

Collections
WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

6 results

IPR Term Analysis Definition
Fzo/mitofusin_HR2 Pfam Fzo/mitofusin HR2 domain
Dynamin_SF Pfam Dynamin superfamily
P-loop_NTPase SUPERFAMILY P-loop containing nucleoside triphosphate hydrolase
Mitofusin-2 PANTHER Mitofusin-2
Mitofusin_fam PANTHER Mitofusin family
G_DYNAMIN_dom ProSiteProfiles Dynamin-type guanine nucleotide-binding (G) domain

GOSlim

37 results

GO Term Annotation Origin Type
nucleotide binding Orthology molecular function
GTPase activity Orthology molecular function
protein binding Orthology molecular function
GTP binding Orthology molecular function
cytoplasm Orthology cellular component
mitochondrion Orthology cellular component
cytosol Orthology cellular component
apoptotic process Orthology biological process
blood coagulation Orthology biological process
microtubule cytoskeleton Orthology cellular component
membrane Orthology cellular component
integral component of membrane Orthology cellular component
hydrolase activity Orthology molecular function
ubiquitin protein ligase binding Orthology molecular function
whole membrane Orthology cellular component
mitochondrial membrane Orthology cellular component
bounding membrane of organelle Orthology cellular component
organelle organization Orthology biological process
establishment of protein localization to organelle Orthology biological process
protein targeting Orthology biological process
response to stress Orthology biological process
response to organic substance Orthology biological process
membrane organization Orthology biological process
intrinsic component of membrane Orthology cellular component
ubiquitin-like protein transferase activity Orthology molecular function
ligase activity Orthology molecular function
cellular protein localization Orthology biological process
peptidase activity, acting on L-amino acid peptides Orthology molecular function
phosphate-containing compound metabolic process Orthology biological process
nucleobase-containing compound metabolic process Orthology biological process
small GTPase mediated signal transduction Orthology biological process
negative regulation of signal transduction Orthology biological process
anatomical structure morphogenesis Orthology biological process
animal organ development Orthology biological process
negative regulation of cell proliferation Orthology biological process
membrane part Orthology cellular component
macromolecular complex Orthology cellular component

GO (Orthology)

30 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type
nucleotide binding Hs molecular function
GTPase activity Hs molecular function
protein binding Hs molecular function
GTP binding Hs molecular function
cytoplasm Hs cellular component
mitochondrion Hs cellular component
mitochondrial outer membrane Hs cellular component
cytosol Hs cellular component
protein targeting to mitochondrion Hs biological process
autophagy Hs biological process
apoptotic process Hs biological process
response to unfolded protein Hs biological process
mitochondrial membrane organization Hs biological process
blood coagulation Hs biological process
mitochondrial fusion Hs biological process
microtubule cytoskeleton Hs cellular component
membrane Hs cellular component
integral component of membrane Hs cellular component
macroautophagy Hs biological process
hydrolase activity Hs molecular function
intrinsic component of mitochondrial outer membrane Hs cellular component
integral component of mitochondrial outer membrane Hs cellular component
ubiquitin protein ligase binding Hs molecular function
protein localization to pre-autophagosomal structure Hs biological process
GTP metabolic process Hs biological process
negative regulation of Ras protein signal transduction Hs biological process
camera-type eye morphogenesis Hs biological process
negative regulation of smooth muscle cell proliferation Hs biological process
mitochondrion localization Hs biological process
outer mitochondrial membrane protein complex Hs cellular component

GO (Blast)

16 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type Score E-value
nucleotide binding Hs molecular function 768 0.0
GTPase activity Hs molecular function 768 0.0
protein binding Hs molecular function 768 0.0
GTP binding Hs molecular function 768 0.0
cytoplasm Hs cellular component 659 0.0
mitochondrion Hs cellular component 768 0.0
mitochondrial outer membrane Hs cellular component 768 0.0
cytosol Hs cellular component 768 0.0
microtubule cytoskeleton Hs cellular component 768 0.0
membrane Hs cellular component 768 0.0
integral component of membrane Hs cellular component 768 0.0
hydrolase activity Hs molecular function 768 0.0
intrinsic component of mitochondrial outer membrane Hs cellular component 768 0.0
integral component of mitochondrial outer membrane Hs cellular component 659 0.0
ubiquitin protein ligase binding Hs molecular function 768 0.0
outer mitochondrial membrane protein complex Hs cellular component 659 0.0

GO (InterProScan)

7 results

GO Term Analysis Type e-value
GTPase activity PANTHER molecular function 1.3E-265
GTP binding ProSiteProfiles molecular function 26.174
mitochondrion PANTHER cellular component 1.3E-265
mitochondrial outer membrane Pfam cellular component 1.5E-52
mitochondrial fusion PANTHER biological process 1.3E-265
integral component of membrane PANTHER cellular component 1.3E-265
negative regulation of smooth muscle cell proliferation PANTHER biological process 1.3E-265