Gene Card
Best human hits
MFN1; MFN2
Species
Unique Gene ID
Harore.g00001422
Gene Model ID
Harore.CG.MTP2014.S110.g01422
Location
S110:199321..204421
Transcript Models and Sequences
Harore.CG.MTP2014.S110.g01422.01.t
Harore.CG.MTP2014.S110.g01422.02.t
n/a
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You can Press 'Ctrl' Key + Left Mouse Click on nodes to do a multiple selection.

IPR Term | Analysis | Definition |
---|---|---|
Fzo/mitofusin_HR2 | Pfam | Fzo/mitofusin HR2 domain |
Dynamin_SF | Pfam | Dynamin superfamily |
P-loop_NTPase | SUPERFAMILY | P-loop containing nucleoside triphosphate hydrolase |
Mitofusin-2 | PANTHER | Mitofusin-2 |
Mitofusin_fam | PANTHER | Mitofusin family |
G_DYNAMIN_dom | ProSiteProfiles | Dynamin-type guanine nucleotide-binding (G) domain |
GO Term | Annotation Origin | Type |
---|---|---|
nucleotide binding | Orthology | molecular function |
GTPase activity | Orthology | molecular function |
protein binding | Orthology | molecular function |
GTP binding | Orthology | molecular function |
cytoplasm | Orthology | cellular component |
mitochondrion | Orthology | cellular component |
cytosol | Orthology | cellular component |
apoptotic process | Orthology | biological process |
blood coagulation | Orthology | biological process |
microtubule cytoskeleton | Orthology | cellular component |
membrane | Orthology | cellular component |
integral component of membrane | Orthology | cellular component |
hydrolase activity | Orthology | molecular function |
ubiquitin protein ligase binding | Orthology | molecular function |
whole membrane | Orthology | cellular component |
mitochondrial membrane | Orthology | cellular component |
bounding membrane of organelle | Orthology | cellular component |
organelle organization | Orthology | biological process |
establishment of protein localization to organelle | Orthology | biological process |
protein targeting | Orthology | biological process |
response to stress | Orthology | biological process |
response to organic substance | Orthology | biological process |
membrane organization | Orthology | biological process |
intrinsic component of membrane | Orthology | cellular component |
ubiquitin-like protein transferase activity | Orthology | molecular function |
ligase activity | Orthology | molecular function |
cellular protein localization | Orthology | biological process |
peptidase activity, acting on L-amino acid peptides | Orthology | molecular function |
phosphate-containing compound metabolic process | Orthology | biological process |
nucleobase-containing compound metabolic process | Orthology | biological process |
small GTPase mediated signal transduction | Orthology | biological process |
negative regulation of signal transduction | Orthology | biological process |
anatomical structure morphogenesis | Orthology | biological process |
animal organ development | Orthology | biological process |
negative regulation of cell proliferation | Orthology | biological process |
membrane part | Orthology | cellular component |
macromolecular complex | Orthology | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type |
---|---|---|
nucleotide binding | Hs | molecular function |
GTPase activity | Hs | molecular function |
protein binding | Hs | molecular function |
GTP binding | Hs | molecular function |
cytoplasm | Hs | cellular component |
mitochondrion | Hs | cellular component |
mitochondrial outer membrane | Hs | cellular component |
cytosol | Hs | cellular component |
protein targeting to mitochondrion | Hs | biological process |
autophagy | Hs | biological process |
apoptotic process | Hs | biological process |
response to unfolded protein | Hs | biological process |
mitochondrial membrane organization | Hs | biological process |
blood coagulation | Hs | biological process |
mitochondrial fusion | Hs | biological process |
microtubule cytoskeleton | Hs | cellular component |
membrane | Hs | cellular component |
integral component of membrane | Hs | cellular component |
macroautophagy | Hs | biological process |
hydrolase activity | Hs | molecular function |
intrinsic component of mitochondrial outer membrane | Hs | cellular component |
integral component of mitochondrial outer membrane | Hs | cellular component |
ubiquitin protein ligase binding | Hs | molecular function |
protein localization to pre-autophagosomal structure | Hs | biological process |
GTP metabolic process | Hs | biological process |
negative regulation of Ras protein signal transduction | Hs | biological process |
camera-type eye morphogenesis | Hs | biological process |
negative regulation of smooth muscle cell proliferation | Hs | biological process |
mitochondrion localization | Hs | biological process |
outer mitochondrial membrane protein complex | Hs | cellular component |
GO Term | SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae |
Type | Score | E-value |
---|---|---|---|---|
nucleotide binding | Hs | molecular function | 768 | 0.0 |
GTPase activity | Hs | molecular function | 768 | 0.0 |
protein binding | Hs | molecular function | 768 | 0.0 |
GTP binding | Hs | molecular function | 768 | 0.0 |
cytoplasm | Hs | cellular component | 659 | 0.0 |
mitochondrion | Hs | cellular component | 768 | 0.0 |
mitochondrial outer membrane | Hs | cellular component | 768 | 0.0 |
cytosol | Hs | cellular component | 768 | 0.0 |
microtubule cytoskeleton | Hs | cellular component | 768 | 0.0 |
membrane | Hs | cellular component | 768 | 0.0 |
integral component of membrane | Hs | cellular component | 768 | 0.0 |
hydrolase activity | Hs | molecular function | 768 | 0.0 |
intrinsic component of mitochondrial outer membrane | Hs | cellular component | 768 | 0.0 |
integral component of mitochondrial outer membrane | Hs | cellular component | 659 | 0.0 |
ubiquitin protein ligase binding | Hs | molecular function | 768 | 0.0 |
outer mitochondrial membrane protein complex | Hs | cellular component | 659 | 0.0 |
GO Term | Analysis | Type | e-value |
---|---|---|---|
GTPase activity | PANTHER | molecular function | 1.3E-265 |
GTP binding | ProSiteProfiles | molecular function | 26.174 |
mitochondrion | PANTHER | cellular component | 1.3E-265 |
mitochondrial outer membrane | Pfam | cellular component | 1.5E-52 |
mitochondrial fusion | PANTHER | biological process | 1.3E-265 |
integral component of membrane | PANTHER | cellular component | 1.3E-265 |
negative regulation of smooth muscle cell proliferation | PANTHER | biological process | 1.3E-265 |