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GENE CARD

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Gene Card

Best human hits

ERN2; PINK1; STK35

Species

H.roretzi

Unique Gene ID

Harore.g00000684

Gene Model ID

Harore.CG.MTP2014.S27.g00684

Location

S27:129369..134072

Transcript Models and Sequences

  Harore.CG.MTP2014.S27.g00684.01.t

External Database Gene Card

External database links

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Genomicus Synteny Browser

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Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

5 results

IPR Term Analysis Definition
Ser/Thr_kinase_AS ProSitePatterns Serine/threonine-protein kinase, active site
Prot_kinase_dom Pfam Protein kinase domain
Prot_kinase_dom ProSiteProfiles Protein kinase domain
Prot_kinase_dom SMART Protein kinase domain
Kinase-like_dom_sf SUPERFAMILY Protein kinase-like domain superfamily

GOSlim

80 results

GO Term Annotation Origin Type
nucleotide binding Orthology molecular function
magnesium ion binding Orthology molecular function
catalytic activity Blast molecular function
protein kinase activity Orthology molecular function
protein serine/threonine kinase activity Orthology molecular function
protein binding Orthology molecular function
ATP binding Orthology molecular function
nucleus Orthology cellular component
nucleolus Blast cellular component
cytoplasm Orthology cellular component
mitochondrion Orthology cellular component
mitochondrial inner membrane Orthology cellular component
endoplasmic reticulum Blast cellular component
endoplasmic reticulum membrane Blast cellular component
cytosol Orthology cellular component
cytoskeleton Orthology cellular component
protein phosphorylation Orthology biological process
response to oxidative stress Orthology biological process
negative regulation of gene expression Orthology biological process
membrane Orthology cellular component
integral component of membrane Orthology cellular component
kinase activity Orthology molecular function
phosphorylation Orthology biological process
protein ubiquitination Orthology biological process
nuclear body Blast cellular component
transferase activity Orthology molecular function
hydrolase activity Blast molecular function
axon Orthology cellular component
ubiquitin protein ligase binding Orthology molecular function
intracellular signal transduction Orthology biological process
negative regulation of apoptotic process Orthology biological process
cell body Orthology cellular component
metal ion binding Orthology molecular function
perinuclear region of cytoplasm Orthology cellular component
intracellular part Orthology cellular component
macromolecular complex Orthology cellular component
organelle organization Orthology biological process
intracellular organelle part Orthology cellular component
intracellular non-membrane-bounded organelle Orthology cellular component
enzyme binding Orthology molecular function
transmembrane transport Orthology biological process
monovalent inorganic cation transport Orthology biological process
regulation of cellular metabolic process Orthology biological process
response to stress Orthology biological process
whole membrane Orthology cellular component
mitochondrial membrane Orthology cellular component
bounding membrane of organelle Orthology cellular component
membrane part Orthology cellular component
mitochondrial envelope Orthology cellular component
intracellular organelle lumen Orthology cellular component
proteolysis Orthology biological process
peptidase activity Orthology molecular function
positive regulation of hydrolase activity Orthology biological process
enzyme activator activity Orthology molecular function
oxidation-reduction process Orthology biological process
cellular metabolic process Orthology biological process
cell projection part Orthology cellular component
chemical synaptic transmission Orthology biological process
cellular response to stress Orthology biological process
protein dephosphorylation Orthology biological process
transcription factor activity, sequence-specific DNA binding Orthology molecular function
positive regulation of signal transduction Orthology biological process
protein kinase binding Orthology molecular function
regulation of apoptotic process Orthology biological process
positive regulation of gene expression Orthology biological process
negative regulation of signal transduction Orthology biological process
positive regulation of catalytic activity Orthology biological process
ubiquitin-protein transferase activity Orthology molecular function
response to hypoxia Orthology biological process
anatomical structure morphogenesis Orthology biological process
positive regulation of apoptotic process Orthology biological process
neuron part Orthology cellular component
cell projection Orthology cellular component
plasma membrane region Orthology cellular component
negative regulation of cell death Orthology biological process
ubiquitin-like protein transferase activity Orthology molecular function
ligase activity Orthology molecular function
peptidase activity, acting on L-amino acid peptides Orthology molecular function
phosphate-containing compound metabolic process Orthology biological process
RNA metabolic process Blast biological process

GO (Orthology)

90 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type
ubiquitin ligase complex Hs cellular component
nucleotide binding Hs molecular function
magnesium ion binding Hs molecular function
autophagy of mitochondrion Hs biological process
chromatin Hs cellular component
positive regulation of protein phosphorylation Hs biological process
protease binding Hs molecular function
regulation of oxidative phosphorylation Hs biological process
response to ischemia Hs biological process
protein kinase activity Hs molecular function
protein serine/threonine kinase activity Hs molecular function
protein binding Hs molecular function
ATP binding Hs molecular function
nucleus Hs cellular component
cytoplasm Hs cellular component
mitochondrion Hs cellular component
mitochondrial outer membrane Hs cellular component
mitochondrial outer membrane translocase complex Hs cellular component
mitochondrial inner membrane Hs cellular component
mitochondrial intermembrane space Hs cellular component
cytosol Hs cellular component
cytoskeleton Hs cellular component
protein phosphorylation Hs biological process
ubiquitin-dependent protein catabolic process Hs biological process
autophagy Hs biological process
response to oxidative stress Hs biological process
mitochondrion organization Hs biological process
regulation of hydrogen peroxide metabolic process Hs biological process
negative regulation of gene expression Hs biological process
regulation of mitochondrion organization Hs biological process
calcium-dependent protein kinase activity Hs molecular function
positive regulation of peptidase activity Hs biological process
membrane Hs cellular component
integral component of membrane Hs cellular component
macroautophagy Hs biological process
positive regulation of macroautophagy Hs biological process
negative regulation of macroautophagy Hs biological process
kinase activity Hs molecular function
phosphorylation Hs biological process
peptidase activator activity Hs molecular function
protein ubiquitination Hs biological process
transferase activity Hs molecular function
peptidyl-serine phosphorylation Hs biological process
respiratory electron transport chain Hs biological process
axon Hs cellular component
growth cone Hs cellular component
integral component of mitochondrial outer membrane Hs cellular component
regulation of protein ubiquitination Hs biological process
positive regulation of protein ubiquitination Hs biological process
ubiquitin protein ligase binding Hs molecular function
TORC2 complex Hs cellular component
positive regulation of synaptic transmission, dopaminergic Hs biological process
positive regulation of peptidyl-serine phosphorylation Hs biological process
cellular response to oxidative stress Hs biological process
positive regulation of protein dephosphorylation Hs biological process
intracellular signal transduction Hs biological process
TORC2 signaling Hs biological process
negative regulation of apoptotic process Hs biological process
positive regulation of I-kappaB kinase/NF-kappaB signaling Hs biological process
protein kinase B binding Hs molecular function
regulation of neuron apoptotic process Hs biological process
negative regulation of neuron apoptotic process Hs biological process
cell body Hs cellular component
positive regulation of translation Hs biological process
negative regulation of JNK cascade Hs biological process
metal ion binding Hs molecular function
perinuclear region of cytoplasm Hs cellular component
protein stabilization Hs biological process
positive regulation of sequence-specific DNA binding transcription factor activity Hs biological process
positive regulation of ubiquitin-protein transferase activity Hs biological process
regulation of mitochondrial membrane potential Hs biological process
positive regulation of protein kinase B signaling Hs biological process
C3HC4-type RING finger domain binding Hs molecular function
regulation of proteasomal protein catabolic process Hs biological process
cellular response to hypoxia Hs biological process
positive regulation of mitochondrial fission Hs biological process
positive regulation of release of cytochrome c from mitochondria Hs biological process
cellular response to toxic substance Hs biological process
Lewy body Hs cellular component
astrocyte projection Hs cellular component
regulation of cellular response to oxidative stress Hs biological process
negative regulation of neuron death Hs biological process
negative regulation of autophagosome assembly Hs biological process
regulation of autophagy of mitochondrion Hs biological process
negative regulation of autophagy of mitochondrion Hs biological process
negative regulation of oxidative stress-induced neuron death Hs biological process
regulation of reactive oxygen species metabolic process Hs biological process
negative regulation of reactive oxygen species metabolic process Hs biological process
positive regulation of ATP biosynthetic process Hs biological process
negative regulation of intrinsic apoptotic signaling pathway Hs biological process

GO (Blast)

45 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae
Type Score E-value
ubiquitin ligase complex Hs cellular component 199 4.06e-56
nucleotide binding Hs molecular function 199 4.06e-56
magnesium ion binding Hs molecular function 199 4.06e-56
chromatin Hs cellular component 199 4.06e-56
protease binding Hs molecular function 199 4.06e-56
catalytic activity Hs molecular function 59.3 5.01e-09
endonuclease activity Hs molecular function 59.3 5.01e-09
ribonuclease activity Hs molecular function 59.3 5.01e-09
protein kinase activity Hs molecular function 199 4.06e-56
protein serine/threonine kinase activity Hs molecular function 199 4.06e-56
protein binding Hs molecular function 199 4.06e-56
ATP binding Hs molecular function 199 4.06e-56
nucleus Hs cellular component 199 4.06e-56
nucleolus Hs cellular component 51.2 1.32e-06
cytoplasm Hs cellular component 199 4.06e-56
mitochondrion Hs cellular component 199 4.06e-56
mitochondrial outer membrane Hs cellular component 199 4.06e-56
mitochondrial outer membrane translocase complex Hs cellular component 199 4.06e-56
mitochondrial inner membrane Hs cellular component 199 4.06e-56
mitochondrial intermembrane space Hs cellular component 199 4.06e-56
endoplasmic reticulum Hs cellular component 59.3 5.01e-09
endoplasmic reticulum membrane Hs cellular component 59.3 5.01e-09
cytosol Hs cellular component 199 4.06e-56
cytoskeleton Hs cellular component 199 4.06e-56
calcium-dependent protein kinase activity Hs molecular function 199 4.06e-56
membrane Hs cellular component 199 4.06e-56
integral component of membrane Hs cellular component 199 4.06e-56
kinase activity Hs molecular function 199 4.06e-56
peptidase activator activity Hs molecular function 199 4.06e-56
nuclear body Hs cellular component 51.2 1.32e-06
transferase activity Hs molecular function 199 4.06e-56
hydrolase activity Hs molecular function 59.3 5.01e-09
axon Hs cellular component 199 4.06e-56
growth cone Hs cellular component 199 4.06e-56
integral component of mitochondrial outer membrane Hs cellular component 199 4.06e-56
ubiquitin protein ligase binding Hs molecular function 199 4.06e-56
TORC2 complex Hs cellular component 199 4.06e-56
protein kinase B binding Hs molecular function 199 4.06e-56
cell body Hs cellular component 199 4.06e-56
metal ion binding Hs molecular function 199 4.06e-56
perinuclear region of cytoplasm Hs cellular component 199 4.06e-56
C3HC4-type RING finger domain binding Hs molecular function 199 4.06e-56
Lewy body Hs cellular component 199 4.06e-56
astrocyte projection Hs cellular component 199 4.06e-56
IRE1-TRAF2-ASK1 complex Hs cellular component 59.3 5.01e-09

GO (InterProScan)

3 results

GO Term Analysis Type e-value
protein kinase activity Pfam molecular function 6.1E-17
ATP binding Pfam molecular function 6.1E-17
protein phosphorylation Pfam biological process 6.1E-17