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Gene Card

Best human hits

IL18R1; MYD88; SIGIRR

Species

C.savignyi

Unique Gene ID

Cisavi.g00010139

Gene Model ID

Cisavi.CG.ENS81.R7.188500-193803

Location

R7:188499..193803

Transcript Models and Sequences

  Cisavi.CG.ENS81.R7.188500-193803.01939.t

External Database Gene Card

External database links

No result

Collections
WashU Genome Browser

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Genomicus Synteny Browser

Genomicus browser link

Regulatory Regions

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

8 results

IPR Term Analysis Definition
Death_domain ProSiteProfiles Death domain
MyD88_Death CDD MyD88, death domain
Toll_tir_struct_dom_sf Gene3D Toll/interleukin-1 receptor homology (TIR) domain superfamily
TIR_dom Pfam Toll/interleukin-1 receptor homology (TIR) domain
Toll_tir_struct_dom_sf SUPERFAMILY Toll/interleukin-1 receptor homology (TIR) domain superfamily
DEATH-like_dom_sf SUPERFAMILY Death-like domain superfamily
Death_domain Pfam Death domain
TIR_dom ProSiteProfiles Toll/interleukin-1 receptor homology (TIR) domain

GOSlim

No result

GO Term Annotation Origin Type

GO (Orthology)

48 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type
toll-like receptor signaling pathway Hs biological process
immune system process Hs biological process
MyD88-dependent toll-like receptor signaling pathway Hs biological process
receptor binding Hs molecular function
Toll binding Hs molecular function
death receptor binding Hs molecular function
interleukin-1 receptor binding Hs molecular function
protein binding Hs molecular function
nucleus Hs cellular component
cytoplasm Hs cellular component
cytosol Hs cellular component
plasma membrane Hs cellular component
apoptotic process Hs biological process
inflammatory response Hs biological process
signal transduction Hs biological process
cell surface receptor signaling pathway Hs biological process
JNK cascade Hs biological process
Toll signaling pathway Hs biological process
response to virus Hs biological process
endosome membrane Hs cellular component
regulation of gene expression Hs biological process
positive regulation of gene expression Hs biological process
postsynaptic density Hs cellular component
immunoglobulin mediated immune response Hs biological process
cytokine-mediated signaling pathway Hs biological process
lipopolysaccharide-mediated signaling pathway Hs biological process
positive regulation of type I interferon production Hs biological process
response to peptidoglycan Hs biological process
response to lipopolysaccharide Hs biological process
toll-like receptor 9 signaling pathway Hs biological process
Toll-like receptor binding Hs molecular function
regulation of cell proliferation Hs biological process
identical protein binding Hs molecular function
negative regulation of apoptotic process Hs biological process
positive regulation of I-kappaB kinase/NF-kappaB signaling Hs biological process
protein self-association Hs molecular function
negative regulation of growth of symbiont in host Hs biological process
innate immune response Hs biological process
positive regulation of JNK cascade Hs biological process
regulation of inflammatory response Hs biological process
defense response to Gram-positive bacterium Hs biological process
positive regulation of NF-kappaB transcription factor activity Hs biological process
interleukin-1-mediated signaling pathway Hs biological process
3'-UTR-mediated mRNA stabilization Hs biological process
TIR domain binding Hs molecular function
cellular response to mechanical stimulus Hs biological process
establishment of endothelial intestinal barrier Hs biological process
regulation of neutrophil migration Hs biological process

GO (Blast)

20 results

GO Term SpeciesCe = Caenorhabditis elegans
Dr = Danio rerio
Dm = Drosophila melanogaster
Gg = Gallus gallus
Hs = Homo sapiens
Mm = Mus musculus
Sc = Saccharomyces cerevisiae		 Type Score E-value
receptor activity Hs molecular function 39.7 0.003
interleukin-1 receptor activity Hs molecular function 39.7 0.003
receptor binding Hs molecular function 102 1.47e-24
Toll binding Hs molecular function 102 1.47e-24
death receptor binding Hs molecular function 102 1.47e-24
interleukin-1 receptor binding Hs molecular function 102 1.47e-24
protein binding Hs molecular function 102 1.47e-24
nucleus Hs cellular component 102 1.47e-24
cytoplasm Hs cellular component 102 1.47e-24
cytosol Hs cellular component 102 1.47e-24
plasma membrane Hs cellular component 102 1.47e-24
endosome membrane Hs cellular component 102 1.47e-24
postsynaptic density Hs cellular component 102 1.47e-24
membrane Hs cellular component 44.3 1.14e-04
integral component of membrane Hs cellular component 44.3 1.14e-04
Toll-like receptor binding Hs molecular function 102 1.47e-24
interleukin-18 receptor activity Hs molecular function 39.7 0.003
identical protein binding Hs molecular function 102 1.47e-24
protein self-association Hs molecular function 102 1.47e-24
TIR domain binding Hs molecular function 102 1.47e-24

GO (InterProScan)

2 results

GO Term Analysis Type e-value
protein binding CDD molecular function 6.05022E-25
signal transduction CDD biological process 6.05022E-25

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