Aniseed - Gene card

Gene Card

Best human hits

SIRT2; SIRT3

Species

C. robusta formely Ciona int. type A

Unique Gene ID

Cirobu.g00015191

Gene Model ID

KH2012:KH.S918.4

Location

KhS918:11769..15751

Transcript Models and Sequences

KH2012:KH.S918.4.v1.A.SL2-1
KH2012:KH.S918.4.v1.R.ND1-1

External Database Gene Card

External database links

1 result

Database	Gene ID
ENSEMBL	ENSCING00000012974

Collections

Gene collection 1 (N. Satoh)

1 result

cits049c18

Plate: R1CiGC35j22

WashU Genome Browser

Click here to view results in the tunicate WashU Browser

Genomicus Synteny Browser

Regulatory Regions

No result

n/a

Gene Phylogeny

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Gene Annotations

InterPro

5 results

IPR Term	Analysis	Definition
Sirtuin_class_I	PIRSF	Sirtuin, class I
DHS-like_NAD/FAD-binding_dom	SUPERFAMILY	DHS-like NAD/FAD-binding domain superfamily
Sirtuin	Pfam	Sirtuin family
Sirtuin_cat_small_dom_sf	Gene3D	Sirtuin, catalytic core small domain superfamily
Ssirtuin_cat_dom	ProSiteProfiles	Sirtuin family, catalytic core domain

GOSlim

77 results

GO Term	Annotation Origin	Type
negative regulation of transcription from RNA polymerase II promoter	Orthology	biological process
immune system process	Orthology	biological process
chromatin binding	Orthology	molecular function
protein binding	Orthology	molecular function
nucleus	Orthology	cellular component
nucleolus	Orthology	cellular component
cytoplasm	Orthology	cellular component
mitochondrion	Orthology	cellular component
mitochondrial matrix	Blast	cellular component
centrosome	Orthology	cellular component
microtubule organizing center	Orthology	cellular component
cytosol	Orthology	cellular component
cytoskeleton	Orthology	cellular component
microtubule	Orthology	cellular component
plasma membrane	Orthology	cellular component
transcription, DNA-templated	Orthology	biological process
regulation of transcription, DNA-templated	Orthology	biological process
cell cycle	Orthology	biological process
nervous system development	Orthology	biological process
transcription factor binding	Orthology	molecular function
zinc ion binding	Orthology	molecular function
negative regulation of cell proliferation	Orthology	biological process
membrane	Orthology	cellular component
hydrolase activity	Orthology	molecular function
enzyme binding	Orthology	molecular function
cell differentiation	Orthology	biological process
midbody	Orthology	cellular component
macromolecular complex	Orthology	cellular component
cell projection	Orthology	cellular component
myelin sheath	Orthology	cellular component
sequence-specific DNA binding	Blast	molecular function
innate immune response	Orthology	biological process
negative regulation of transcription, DNA-templated	Orthology	biological process
positive regulation of transcription from RNA polymerase II promoter	Orthology	biological process
metal ion binding	Orthology	molecular function
perinuclear region of cytoplasm	Orthology	cellular component
cell division	Orthology	biological process
organelle organization	Orthology	biological process
intracellular organelle part	Orthology	cellular component
intracellular non-membrane-bounded organelle	Orthology	cellular component
cellular protein modification process	Orthology	biological process
nucleoplasm part	Orthology	cellular component
nuclear lumen	Orthology	cellular component
cytoplasmic part	Orthology	cellular component
cytoskeletal part	Orthology	cellular component
microtubule cytoskeleton	Orthology	cellular component
mitotic cell cycle phase transition	Orthology	biological process
intracellular signal transduction	Orthology	biological process
negative regulation of gene expression	Orthology	biological process
cellular process	Orthology	biological process
cell development	Orthology	biological process
neurogenesis	Orthology	biological process
cell projection part	Orthology	cellular component
axon	Orthology	cellular component
proteolysis	Orthology	biological process
cell junction	Orthology	cellular component
cellular response to stress	Orthology	biological process
response to oxidative stress	Orthology	biological process
protein metabolic process	Orthology	biological process
phosphorylation	Orthology	biological process
regulation of cellular metabolic process	Orthology	biological process
neuronal cell body	Orthology	cellular component
DNA binding	Orthology	molecular function
reproductive process	Orthology	biological process
animal organ development	Orthology	biological process
cell surface receptor signaling pathway	Orthology	biological process
response to stimulus	Orthology	biological process
anion binding	Orthology	molecular function
nucleotide binding	Orthology	molecular function
coenzyme binding	Orthology	molecular function
response to molecule of bacterial origin	Orthology	biological process
response to hypoxia	Orthology	biological process
plasma membrane region	Orthology	cellular component
gamete generation	Orthology	biological process
defense response	Orthology	biological process
response to bacterium	Orthology	biological process
transferase activity	Blast	molecular function

GO (Orthology)

93 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type
negative regulation of transcription from RNA polymerase II promoter	Hs	biological process
chromatin silencing at rDNA	Hs	biological process
chromosome, telomeric region	Hs	cellular component
immune system process	Hs	biological process
chromatin binding	Hs	molecular function
histone deacetylase activity	Hs	molecular function
protein binding	Hs	molecular function
nucleus	Hs	cellular component
chromatin silencing complex	Hs	cellular component
chromosome	Hs	cellular component
nuclear heterochromatin	Hs	cellular component
nucleolus	Hs	cellular component
cytoplasm	Hs	cellular component
mitochondrion	Hs	cellular component
centrosome	Hs	cellular component
centriole	Hs	cellular component
microtubule organizing center	Hs	cellular component
spindle	Hs	cellular component
cytosol	Hs	cellular component
cytoskeleton	Hs	cellular component
microtubule	Hs	cellular component
plasma membrane	Hs	cellular component
chromatin silencing	Hs	biological process
chromatin silencing at telomere	Hs	biological process
transcription, DNA-templated	Hs	biological process
regulation of transcription, DNA-templated	Hs	biological process
protein ADP-ribosylation	Hs	biological process
protein deacetylation	Hs	biological process
autophagy	Hs	biological process
cell cycle	Hs	biological process
regulation of exit from mitosis	Hs	biological process
nervous system development	Hs	biological process
transcription factor binding	Hs	molecular function
zinc ion binding	Hs	molecular function
negative regulation of cell proliferation	Hs	biological process
negative regulation of autophagy	Hs	biological process
phosphatidylinositol 3-kinase signaling	Hs	biological process
membrane	Hs	cellular component
gene silencing	Hs	biological process
histone deacetylation	Hs	biological process
hydrolase activity	Hs	molecular function
NAD-dependent histone deacetylase activity	Hs	molecular function
myelination in peripheral nervous system	Hs	biological process
cell differentiation	Hs	biological process
growth cone	Hs	cellular component
midbody	Hs	cellular component
regulation of myelination	Hs	biological process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Hs	biological process
paranodal junction	Hs	cellular component
paranode region of axon	Hs	cellular component
protein deacetylase activity	Hs	molecular function
cellular response to oxidative stress	Hs	biological process
NAD-dependent protein deacetylase activity	Hs	molecular function
histone acetyltransferase binding	Hs	molecular function
negative regulation of protein catabolic process	Hs	biological process
regulation of phosphorylation	Hs	biological process
histone deacetylase binding	Hs	molecular function
tubulin deacetylase activity	Hs	molecular function
cell projection	Hs	cellular component
ubiquitin binding	Hs	molecular function
proteasome-mediated ubiquitin-dependent protein catabolic process	Hs	biological process
perikaryon	Hs	cellular component
myelin sheath	Hs	cellular component
lateral loop	Hs	cellular component
Schmidt-Lanterman incisure	Hs	cellular component
positive regulation of DNA binding	Hs	biological process
protein kinase B signaling	Hs	biological process
juxtaparanode region of axon	Hs	cellular component
innate immune response	Hs	biological process
positive regulation of meiotic nuclear division	Hs	biological process
negative regulation of striated muscle tissue development	Hs	biological process
negative regulation of transcription, DNA-templated	Hs	biological process
positive regulation of transcription from RNA polymerase II promoter	Hs	biological process
metal ion binding	Hs	molecular function
NAD-dependent histone deacetylase activity (H4-K16 specific)	Hs	molecular function
hepatocyte growth factor receptor signaling pathway	Hs	biological process
perinuclear region of cytoplasm	Hs	cellular component
cell division	Hs	biological process
meiotic cell cycle	Hs	biological process
regulation of cell cycle	Hs	biological process
response to redox state	Hs	biological process
positive regulation of cell division	Hs	biological process
NAD+ binding	Hs	molecular function
histone H3 deacetylation	Hs	biological process
cellular response to molecule of bacterial origin	Hs	biological process
cellular response to hypoxia	Hs	biological process
mitotic spindle	Hs	cellular component
meiotic spindle	Hs	cellular component
tubulin deacetylation	Hs	biological process
glial cell projection	Hs	cellular component
positive regulation of oocyte maturation	Hs	biological process
negative regulation of defense response to bacterium	Hs	biological process
negative regulation of reactive oxygen species metabolic process	Hs	biological process

GO (Blast)

52 results

GO Term	SpeciesCe = Caenorhabditis elegans Dr = Danio rerio Dm = Drosophila melanogaster Gg = Gallus gallus Hs = Homo sapiens Mm = Mus musculus Sc = Saccharomyces cerevisiae	Type	Score	E-value
chromosome, telomeric region	Hs	cellular component	377	4.72e-131
chromatin binding	Hs	molecular function	377	4.72e-131
NAD+ ADP-ribosyltransferase activity	Hs	molecular function	285	5.67e-95
histone deacetylase activity	Hs	molecular function	377	4.72e-131
protein binding	Hs	molecular function	377	4.72e-131
nucleus	Hs	cellular component	377	4.72e-131
chromatin silencing complex	Hs	cellular component	377	4.72e-131
chromosome	Hs	cellular component	377	4.72e-131
nuclear heterochromatin	Hs	cellular component	377	4.72e-131
nucleolus	Hs	cellular component	377	4.72e-131
cytoplasm	Hs	cellular component	377	4.72e-131
mitochondrion	Hs	cellular component	377	4.72e-131
mitochondrial matrix	Hs	cellular component	285	5.67e-95
centrosome	Hs	cellular component	377	4.72e-131
centriole	Hs	cellular component	377	4.72e-131
microtubule organizing center	Hs	cellular component	377	4.72e-131
spindle	Hs	cellular component	377	4.72e-131
cytosol	Hs	cellular component	377	4.72e-131
cytoskeleton	Hs	cellular component	377	4.72e-131
microtubule	Hs	cellular component	377	4.72e-131
plasma membrane	Hs	cellular component	377	4.72e-131
transcription factor binding	Hs	molecular function	377	4.72e-131
zinc ion binding	Hs	molecular function	377	4.72e-131
membrane	Hs	cellular component	377	4.72e-131
hydrolase activity	Hs	molecular function	377	4.72e-131
NAD-dependent histone deacetylase activity	Hs	molecular function	377	4.72e-131
enzyme binding	Hs	molecular function	285	5.67e-95
growth cone	Hs	cellular component	377	4.72e-131
midbody	Hs	cellular component	377	4.72e-131
macromolecular complex	Hs	cellular component	285	5.67e-95
paranodal junction	Hs	cellular component	377	4.72e-131
paranode region of axon	Hs	cellular component	377	4.72e-131
protein deacetylase activity	Hs	molecular function	377	4.72e-131
NAD-dependent protein deacetylase activity	Hs	molecular function	377	4.72e-131
histone acetyltransferase binding	Hs	molecular function	377	4.72e-131
histone deacetylase binding	Hs	molecular function	377	4.72e-131
tubulin deacetylase activity	Hs	molecular function	377	4.72e-131
cell projection	Hs	cellular component	377	4.72e-131
ubiquitin binding	Hs	molecular function	377	4.72e-131
perikaryon	Hs	cellular component	377	4.72e-131
myelin sheath	Hs	cellular component	377	4.72e-131
lateral loop	Hs	cellular component	377	4.72e-131
Schmidt-Lanterman incisure	Hs	cellular component	377	4.72e-131
sequence-specific DNA binding	Hs	molecular function	285	5.67e-95
juxtaparanode region of axon	Hs	cellular component	377	4.72e-131
metal ion binding	Hs	molecular function	377	4.72e-131
NAD-dependent histone deacetylase activity (H4-K16 specific)	Hs	molecular function	377	4.72e-131
perinuclear region of cytoplasm	Hs	cellular component	377	4.72e-131
NAD+ binding	Hs	molecular function	377	4.72e-131
mitotic spindle	Hs	cellular component	377	4.72e-131
meiotic spindle	Hs	cellular component	377	4.72e-131
glial cell projection	Hs	cellular component	377	4.72e-131

GO (InterProScan)

3 results

GO Term	Analysis	Type	e-value
zinc ion binding	PIRSF	molecular function	1.3E-139
NAD-dependent histone deacetylase activity	PIRSF	molecular function	1.3E-139
NAD+ binding	Pfam	molecular function	2.1E-60